小青龙汤治疗小儿喘息样支气管炎的优势及机制探究

发布时间：2018-03-26 07:31

本文选题：小青龙汤　切入点：小儿　出处：《中华中医药学刊》2017年11期

【摘要】：目的:通过检测小儿喘息样支气管炎患者治疗前后血清中IL-2、IL-10、Ig E及炎症因子水平的变化,探讨小青龙汤治疗小儿喘支炎的的优势及机制,并为小儿喘支炎的临床治疗以及判断预后提供实验依据。方法:选取2015年6月—2016年12月三甲医院儿科小儿喘支炎患者126例,所有患者按照平行对照原则随机分为两组,每组纳入63名患者。对照组采用常规治疗法,实验组应用常规治疗的同时给予小青龙汤治疗。结果:经过治疗后,实验组患儿各种临床症状缓解时间及平均住院时间较对照组患儿显著缩短,组间差异具有显著性(P0.05)。实验组的总体有效率为90.5%,对照组的总体有效率为68.3%,实验组效果更加显著(P0.05)。两组患儿治疗后,实验组患儿的血清炎性因子(hs-CRP、TNF-α、Ig E)水平较对照组患儿改善更加显著,两组之间差异具有统计学意义(P0.05)。结论:采用小青龙汤治疗小儿高发的喘支炎可以有效的缩短患儿病程,提高治愈率,其机制可能为通过调节细胞因子含量来平衡免疫细胞功能,从而减轻炎症反应达到治疗效果。
[Abstract]:Objective: to investigate the advantage and mechanism of Xiao Azure Dragon decoction in treating asthmatic bronchitis in children by detecting the changes of serum IL-2T IL-10 Ig E and inflammatory cytokines before and after treatment in children with asthmatic bronchitis. Methods: 126 pediatric patients with pediatric asthmatic bronchitis from June 2015 to December 2016 were randomly divided into two groups according to the principle of parallel control. Each group included 63 patients. The control group was treated with routine therapy, while the experimental group was treated with Xiao Azure Dragon decoction. Results: after treatment, The clinical symptom remission time and average hospitalization time in the experimental group were significantly shorter than those in the control group. The total effective rate of the experimental group was 90.5, the total effective rate of the control group was 68.3, the effect of the experimental group was more remarkable than that of the control group. The level of serum inflammatory factor TNF- 伪 Ig E in the experimental group was significantly improved than that in the control group, and the difference between the two groups was statistically significant (P 0.05). Conclusion: the treatment of high incidence asthmatic bronchitis in children with Xiao Azure Dragon decoction can effectively shorten the course of the disease. The mechanism of increasing the cure rate may be to balance the function of immune cells by regulating the content of cytokines so as to reduce the inflammatory reaction and achieve therapeutic effect.
【作者单位】：黔东南州中医医院;
【分类号】：R272

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