内异康复片治疗湿热瘀阻型子宫内膜异位症盆腔疼痛的临床研究

发布时间：2018-03-26 12:15

本文选题：EMT盆腔疼痛　切入点：湿热瘀阻型　出处：《成都中医药大学》2016年硕士论文

【摘要】：目的：以孕三烯酮为对照组,观察内异康复片治疗湿热瘀阻型子宫内膜异位症(EMT)盆腔疼痛的临床疗效,为湿热瘀阻型EMT盆腔疼痛的中医药治疗提供有效的治疗思路及临床用药依据。方法：将符合EMT湿热瘀阻型诊断标准的72例患者,随机分为治疗组与对照组,治疗组予内异康复片口服,对照组予孕三烯酮胶囊口服,均用药3个月。观察两组治疗前后各症状体征积分及相关疗效指标和安全性指标变化情况。结果：(1)单项指标疗效比较：在缩小卵巢巧克力囊肿直径方面,两组组内比较,差异有统计学意义(P0.05)；组间比较,差异有统计学意义(P0.05),对照组优于治疗组。在降低血清肿瘤标记物CA-125水平方面,两组组内比较,差异有统计学意义(P0.05)；组间比较,差异无统计学意义(P0.05),治疗组与对照组疗效相当。在EMT患者生存质量量表评分方面,治疗前后组内比较,差异均有统计学意义(P0.05),两组均可改善EMT患者的生活质量。(2)两组主症疗效比较：治疗组总有效率为91.5%：对照组总有效率为88.6%;组内比较,差异有统计学意义(P0.05)；组间比较,差异无统计学意义(P0.05),治疗组与对照组疗效相当。(3)两组中医证候疗效比较：治疗组总有效率为88.6%；对照组总有效率为60.0%；组内比较,差异均有统计学意义(P0.05);组间比较,差异有统计学意义(P0.05),治疗组疗效优于对照组。(4)两组局部体征疗效比较：治疗组总有效率为88.6%：对照组总有效率为85.7%,组内比较,差异有统计学意义(P0.05)：组间比较,差异无统计学意义(P0.05),治疗组与对照组疗效相当。(5)两组综合疗效比较：治疗组总有效率为88.6%：对照组总有效率为80.0%,组内比较,差异有统计学意义(P0.05)；组间比较,差异有统计学意义(P0.05),治疗组疗效优于对照组。(6)安全性结果分析：本实验对照组共出现2例不良事件,考虑与药物有关；治疗组则未出现不良反应。结论：(1)治疗组与对照组在治疗EMT所致的盆腔疼痛、降低血清CA-125水平、缓解该病的局部体征方面疗效相当,二者均可以改善EMT患者的生活质量；(2)治疗组治疗湿热瘀阻型EMT的中医证候疗效、综合疗效明显优于对照组,而且副作用少。(3)内异康复片治疗湿热瘀阻证EMT安全有效,值得临床推广。
[Abstract]:Objective: to observe the clinical effect of Neiyikangfu tablet on pelvic pain of endometriosis with damp-heat ecchymosis as control group. Methods: 72 patients with damp-heat stasis type EMT pelvic pain were randomly divided into treatment group and control group. The treatment group was treated with Nei Yi Kang tablet and the control group with pregnancy trienone capsule. All patients were treated for 3 months. The changes of the scores of symptoms and signs, the related curative effect indexes and the safety indexes before and after treatment were observed. Results comparison of the single index: in reducing the diameter of ovarian chocolate cyst, the difference between the two groups was compared. The difference was statistically significant (P 0.05), the difference was statistically significant (P 0.05), and the control group was superior to the treatment group (P 0.05). There was a significant difference between the two groups in reducing the serum tumor marker CA-125 level (P 0.05), and the difference between the two groups was significant (P 0.05). The difference was not statistically significant (P 0.05). The curative effect of the treatment group was similar to that of the control group. In terms of quality of life (QOL) score of patients with EMT, there was a comparison between the two groups before and after treatment. The difference was statistically significant (P 0.05). Both groups could improve the quality of life (QOL) of EMT patients. The curative effects of the two groups were as follows: the total effective rate in the treatment group was 91.5 and the total effective rate in the control group was 88.60.The difference was statistically significant in intra-group comparison (P 0.05). There was no significant difference between the two groups (P 0.05). The curative effect of the treatment group was similar to that of the control group. (3) the total effective rate of the treatment group was 88.6; the total effective rate of the control group was 60.0; the difference within the group was statistically significant; the difference between the two groups was statistically significant; and between the two groups, the total effective rate of the treatment group was 88.60.The total effective rate of the control group was 60.05g. The difference was statistically significant (P 0.05). The curative effect of the treatment group was better than that of the control group. (4) the total effective rate of the treatment group was 88.6; the total effective rate of the control group was 85.7%; the difference between the two groups was statistically significant (P 0.05). The total effective rate of the treatment group was 88.6; the total effective rate of the control group was 80.05.There was significant difference between the treatment group and the control group (P 0.05). The difference was statistically significant (P 0.05). The efficacy of the treatment group was better than that of the control group. (6) Analysis of the safety results: there were 2 cases of adverse events in this experimental control group, considering drug related; Conclusion the treatment group and the control group have the same efficacy in the treatment of pelvic pain caused by EMT, the reduction of serum CA-125 level, and the relief of local signs of the disease. Both of them could improve the quality of life of patients with EMT. (2) in the treatment group, the TCM syndromes of dampness and heat stasis type EMT were obviously superior to those in the control group, and the side effects were less. 3) Neishikangfu tablet was safe and effective in the treatment of dampness and heat stasis syndrome EMT. It is worth popularizing in clinic.
【学位授予单位】：成都中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R271.9

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