穴位注射治疗肠癌化疗后脾肾阳虚型白细胞减少症的临床研究

发布时间：2018-03-29 12:16

本文选题：穴位注射　切入点：结直肠癌　出处：《云南中医学院》2017年硕士论文

【摘要】：研究目的:研究足三里穴位注射参附注射液对结直肠癌化疗后脾肾阳虚型白细胞减少症的疗效,探讨采用穴位注射的治疗手段,以健脾益肾为主要治疗法则,治疗结直肠癌化疗后脾肾阳虚型白细胞减少症的治疗方法。为中西医结合治疗结直肠癌化疗后脾肾阳虚型白细胞减少症治疗提供新的思路。研究方法:随机将72例结直肠癌化疗后脾肾阳虚型白细胞减少症的患者,分配至治疗组(足三里穴位注射参附注射液1ml,每日1次)与对照组(口服十一味参芪片,每次4片,每日3次)。评价治疗前后的证候积分、白细胞及中性粒细胞计数的改善情况并进行统计学分析。研究结果:1.两组治疗手段均可以降低临床中医证候积分(P0.01)。在治疗第4、7天治疗组的证候积分明显低于对照组(P0.01)。2.治疗组的疗效在治疗第4天明显优于对照组(P0.01)。治疗组的疗效在治疗第7天仍优于对照组(P0.05)。3.两组治疗手段均可以升高血清白细胞计数(P0.01)。在治疗第4、7天治疗组的白细胞计数均明显高于对照组(P0.01)。4.两组治疗手段均可以升高血清中性粒细胞计数(P0.01)。在治疗第4天两组的中性粒细胞计数并无差异(P0.05);在治疗第7天治疗组的中性粒细胞计数高于对照组(P0.05)。5.在治疗第4天治疗组的实验室疗效优于对照组(P0.05);在治疗第7天治疗组的实验室检查疗更是效优于对照组(P0.01)。6.两组治疗手段均可以提升Karnofsky评分分数(P0.01)。在治疗后治疗组的Karnofsky评分分数明显高于对照组(P0.01)。研究结论:本研究结果显示足三里穴位注射参附注射液治疗结直肠癌化疗后脾肾阳虚型白细胞减少症,在中医证候的改善、白细胞和中性粒细胞计数的升高、Karnofsky评分的提高等方面明显优于口服十一味参芪片组,且具有统计学意义。说明采用足三里穴位注射参附注射液的治疗方法,可改善临床症状,提高生活质量,有效治疗白细胞减少症,提高化疗的耐受性。
[Abstract]:Objective: to study the therapeutic effect of Shenfu injection at Zusanli acupoint on leucopenia of spleen and kidney yang deficiency type after chemotherapy in colorectal cancer. The treatment method of leukopenia of spleen and kidney yang deficiency type after chemotherapy for colorectal cancer provides a new way of thinking for the treatment of leukopenia of spleen and kidney yang deficiency type after chemotherapy of colorectal cancer by combining traditional Chinese and western medicine. A case of leukopenia with deficiency of spleen and kidney yang after chemotherapy for colorectal cancer, To the treatment group (Zusanli acupoint injection of Shenfu injection 1 ml, once a day) and the control group (oral 10 blindly Shenqi tablets, 4 tablets each time, 3 times a day). The syndrome score before and after treatment was evaluated. The improvement of leukocyte and neutrophil count was analyzed statistically. The results showed that both treatment methods could decrease the clinical TCM syndrome score (P 0.01). The syndromes score in the treatment group was significantly lower than that in the control group on the 4th day of treatment. The therapeutic effect of the treatment group was significantly better than that of the control group on the 4th day. The therapeutic effect of the treatment group was still better than that of the control group on the 7th day. WBC count was significantly higher than that of control group (P 0.01). Both groups could increase serum neutrophil count (P 0.01). There was no difference in neutrophil count between the two groups on the 4th day of treatment, and the neutrophil count in the treatment group on the 7th day. The cell count was higher than that of the control group (P 0.05). The laboratory efficacy of the treatment group was better than that of the control group on the 4th day, and that of the treatment group on the 7th day was even better than that of the control group (P 0.01. 6. 6). Both treatment methods could improve the score of Karnofsky score. The Karnofsky score of the treatment group was significantly higher than that of the control group (P 0.01). Conclusion: the results of this study showed that injection of Shenfu injection at Zusanli acupoint was effective in the treatment of leukopenia with deficiency of spleen and kidney yang after chemotherapy for colorectal cancer. The improvement of TCM syndromes, the increase of leukocyte and neutrophil count and the improvement of Karnofsky score were obviously superior to those in the oral Shenqi tablet group, and had statistical significance. It can improve the clinical symptoms, improve the quality of life, effectively treat leukopenia, and improve the tolerance of chemotherapy.
【学位授予单位】：云南中医学院
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R273

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