“肝肾同治”中药复方治疗帕金森病抑郁的系统评价

发布时间：2018-03-29 22:25

本文选题：肝肾同治　切入点：帕金森病抑郁　出处：《广西中医药大学》2017年硕士论文

【摘要】：目的:系统评价“肝肾同治”中药复方治疗帕金森病抑郁(depress ion in Parkinson’s disease,DPD)的有效性和安全性。方法:通过制定严格的检索策略,计算机检索中国生物医学文献数据库(CBM)、中国学术期刊全文数据库(CNKI)、中文科技期刊全文数据库(VIP)、万方数据知识服务平台、中国临床试验注册中心(ChiCTR)、PubMed、Cochrane Library和Embase,检索时间为各建库时间到2017年1月31日,对检索到的临床研究文献及综述的参考文献再进行回溯性检索和引文检索以补充资料。严格按照纳入与排除标准纳入符合的文献资料,资料的获取由两名研究员独立完成。根据Cochrane协作网的偏倚风险评价工具评价偏倚风险,提取资料并进行统计分析。采用Revman 5.3软件进行数据分析,通过绘制森林图和偏倚风险总结图等得出综合结论。结果:共纳入15项研究,统计分析结果显示:与对照组相比,“肝肾同治”中药复方治疗DPD在有效率、汉密顿抑郁量表(Hamilton Depression Scale,HAMD)评分比较、统一帕金森病评定量表(unified Parkinson diease rating scale,UPDRS)总评分比较的结果优于对照组。纳入的研究中有2项报道了日常生活能力量表(activity of daily living scale,ADL)评分,因存在很大的临床异质性,未进行数据的合并,2项均发现,治疗后试验组与对照相比具有显著统计学意义(P0.01)。9项研究进行了安全性分析,其中有2项研究采用副反应量表(Treatment Emergent Symptom Scale,TESS)对不良反应进行评价,均提示差异具有显著统计学意义(P0.01)。结论:本次系统评价提示:“肝肾同治”中药复方治疗DPD有效,但需进行设计合理、执行正确以及报告充分的随机对照试验,以进一步获得较高级别的临床证据。
[Abstract]:Objective: to evaluate the efficacy and safety of "liver and kidney combined therapy" in the treatment of Parkinson's disease depress ion in Parkinson's disease.Methods: according to the strict retrieval strategy, the Chinese Biomedical Literature Database (CBMN), the Chinese academic Journal Full-text Database (CNKI), the Chinese Sci-tech Journal Full-text Database (VIPI), and the Wanfang data knowledge Service platform were searched by computer.Library and Embase of Chinese Clinical trial Registry were collected. The retrieval time was from January 31, 2017. The retrieved clinical research literatures and reviewed references were retrieved retrospectively and citation to supplement the data.According to the inclusion and exclusion criteria, the data were obtained by two researchers independently.The bias risk was evaluated according to the bias risk assessment tool of Cochrane cooperation network, and the data were extracted and analyzed statistically.Revman 5.3 software was used for data analysis and comprehensive conclusions were obtained by drawing forest map and bias risk summary map.Results: a total of 15 studies were included. The results of statistical analysis showed that compared with the control group, the effective rate of traditional Chinese medicine compound "liver and kidney treatment" for DPD was higher than that in the control group. Hamilton Depression scale scale score was compared with that in the control group.The results of the unified Parkinson diease rating scale scale were better than those of the control group.Two of the included studies reported the activity of daily living scale (ADL) score. Due to the large clinical heterogeneity, both of the two items without data were found.The safety analysis was performed in the experimental group compared with the control group (P 0.01), 2 of which were evaluated with treatment Emergent Symptom scale and TESS, which indicated that the difference was statistically significant (P 0.01).Conclusion: this systematic evaluation indicates that "liver and kidney treatment" is effective in the treatment of DPD, but it is necessary to carry out a randomized controlled trial with reasonable design, correct execution and sufficient report, in order to obtain higher grade clinical evidence.
【学位授予单位】：广西中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R277.7

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