小陷胸汤合丹参饮治疗高血压病（痰瘀互结型）临床疗效观察及对凝血功能的影响

发布时间：2018-04-01 01:28

本文选题：小陷胸汤　切入点：丹参饮　出处：《黑龙江中医药大学》2016年硕士论文

【摘要】：目的：观察小陷胸汤合丹参饮治疗高血压病(痰瘀互结型)的临床疗效及对凝血功能各项指标(PT、APTT、FIB)的影响。方法：将符合纳入标准的60例患者随机分为：治疗组(30例)和对照组(30例)。对照组只进行基础治疗(硝苯地平缓释片10mg/次,日2次口服；阿司匹林肠溶片100mg/次,每晚一次口服)。治疗组在基础治疗上,给予小陷胸汤合丹参饮。治疗2周后观察两组患者血压、中医证候积分及凝血功能的变化。采用SPSS 20.0软件进行数据的统计与分析。结果：1.治疗2周后,两组患者的SBP和DBP均较治疗前下降,且差异有统计学意义(P0.05)；治疗后治疗组和对照组的血压有效率分别为87%、77%；治疗组经治疗2周后,SBP下降程度明显大于对照组,两组对比差异显著,有统计学意义(P0.05)。2.两组患者治疗2周后中医证候变化情况有所改善；总有效率63%,差异有统计学意义(P0.05),经治疗2周后治疗组患者的中医证候改善情况优于对照组(P0.01)。3.两组患者治疗2周,治疗组凝血功能指标PT、APTT较治疗前延长(P0.05),FIB水平较治疗前下降(P0.05)；治疗后与对照组比较,治疗组的凝血功能改善(P0.05)。结论：1.小陷胸汤合丹参饮可以改善高血压病(痰瘀互结型)患者的中医证候,降低血压。2.小陷胸汤合丹参饮可以改善高血压病(痰瘀互结型)的凝血功能。
[Abstract]:Objective: to observe the clinical effect of Xiaoxiongtang combined with Danshen decoction in the treatment of hypertension (phlegm and blood stasis type) and its effect on coagulation function index (PTT APTTT FIBB). Methods: 60 patients who met the inclusion criteria were randomly divided into treatment group (30 cases) and treatment group (30 cases). The control group received only basic treatment (nifedipine sustained release tablets 10mg/ times) and the control group (30 cases). Two times a day; 100mg/, aspirin enteric-coated tablets, once a night. The treatment group was treated with Xiaohuaoxiongtang and Danshen decoction. After 2 weeks of treatment, the blood pressure of the two groups was observed. The changes of TCM syndromes integral and coagulation function. The data were analyzed by SPSS 20.0 software. Results: after 2 weeks of treatment, the SBP and DBP of the two groups were lower than those before treatment. The effective rates of blood pressure in the treatment group and the control group were 87 and 777.The decrease of SBP in the treatment group was significantly higher than that in the control group after 2 weeks of treatment, and the difference between the two groups was significant. There was significant difference between the two groups after 2 weeks of treatment, the changes of TCM syndromes were improved. The total effective rate was 63.The difference was statistically significant (P 0.05). After 2 weeks of treatment, the improvement of TCM syndromes in the treatment group was better than that in the control group (P 0.01) .3.The patients in the two groups were treated for 2 weeks. In the treatment group, the blood coagulation function index PTT APTT was longer than that before treatment, and the FIB level was lower than that before treatment, and compared with that in the control group after treatment. Conclusion 1. Xiaoxiaoxiongtang combined with Danshen decoction can improve the TCM syndromes of patients with essential hypertension (phlegm and blood stasis type). Reduce blood pressure. 2. Xiaoxiaoxiao decoction combined with Danshen decoction can improve the coagulation function of hypertension (phlegm and blood stasis type).
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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