口炎清颗粒对头颈部恶性肿瘤患者放疗后放射性口腔黏膜炎的防治作用

发布时间：2018-04-02 02:30

本文选题：口炎清颗粒　切入点：头颈部肿瘤　出处：《中国药房》2017年27期

【摘要】：目的:探讨口炎清颗粒对头颈部恶性肿瘤患者放疗后放射性口腔黏膜炎的防治作用。方法:122例行放疗的头颈部恶性肿瘤患者随机分为口炎清组(61例)和氯己定组(61例)。在放疗的基础上,口炎清组患者于放疗前2~3 d给予口炎清颗粒20 g,溶于50 m L温开水含服,每日2次;氯己定组患者于放疗前2~3 d给予复方氯己定含漱液10~20 m L,含漱,每日2次。两组疗程均为7周。观察两组患者口腔黏膜炎反应发生情况,视觉模拟(VAS)评分及不良反应发生情况。结果:放疗第3周后口炎清组患者2~3级及放疗第4~7周后2~4级口腔黏膜炎发生率均显著低于氯己定组同期,差异均有统计学意义(P0.01)。放疗第2~7周后,口炎清组患者VAS评分均显著低于氯己定组,差异均有统计学意义(P0.01)。两组患者不良反应发生率比较,差异无统计学意义(P0.05)。结论:口炎清颗粒可降低头颈部恶性肿瘤患者放疗后放射性口腔黏膜炎的反应严重程度,减轻患者疼痛,改善患者生存质量,且安全性与氯己定相当。
[Abstract]:Objective: to investigate the preventive and therapeutic effect of stomatitis Qing granule on radiation oral mucositis after radiotherapy in patients with head and neck malignant tumor. Methods: 122 patients with head and neck malignant tumor were randomly divided into stomatitis control group (n = 61) and chlorhexidine group (n = 61). On the basis of radiotherapy, The patients in the stomatitis control group were given oral tonifying granule 20 g, dissolved in 50 mL warm boiled water, twice daily, and those in the chlorhexidine group were given compound chlorhexidine gargle 1020 mL, 23 days before radiotherapy, and the patients in the chlorhexidine group received 10 20 mL of compound chlorhexidine gargle 3 days before radiotherapy, and the patients in the chlorhexidine group received 10 20 mL of compound chlorhexidine gargle. Two times a day. The course of treatment was 7 weeks. The occurrence of oral mucositis in the two groups was observed. Results: the incidences of oral mucositis in the oral inflammation group after 3 weeks of radiotherapy were significantly lower than those in the chlorhexidine group. After 2 weeks of radiotherapy, the VAS scores of the patients with stomatitis were significantly lower than those of the chlorhexidine group, and the difference was statistically significant (P 0.01). The incidence of adverse reactions in the two groups was higher than that in the control group. Conclusion: the oral mucositis of patients with malignant tumor of head and neck after radiotherapy can reduce the severity of radiation oral mucositis, relieve the pain of patients, improve the quality of life of patients, and the safety of oral mucositis is similar to that of chlorhexidine.
【作者单位】：台州市立医院口腔科;台州恩泽医疗中心(集团)浙江省台州医院;
【基金】：浙江省中医药科技计划项目(No.2013ZA131)
【分类号】：R276.8

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