溃结方灌肠治疗大肠湿热型溃疡性结肠炎的临床研究

发布时间：2018-04-02 07:30

本文选题：溃疡性结肠炎　切入点：溃结方　出处：《山西中医学院》2016年硕士论文

【摘要】：研究背景:现代生活变化日新月异,物质生活水平有所提高,以及诊断技术的不断提升,随之改变的是UC的发病率逐年增高的趋势在我国日益显现。由于UC病变范围相较其他疾病比较广泛、易反复发作、常经久不愈,癌变的可能性极大。因此,患者长期困扰于此,然而现代医学对其治疗效果不甚理想,世界卫生组织已将其确认为当今难治性疾病。溃疡性结肠炎的复发已然成为世界性的难题,采用中药治疗经济实用,进而解除患者的病痛,有效提高其生活质量。目的:观察总结溃结方灌肠治疗大肠湿热型溃疡性结肠炎中医症候的改善情况和临床疗效。方法:按照随机,对照的原则将收集山西省中医院住院和门诊病例中筛选出100例经诊断为大肠湿热型溃疡性结肠炎的患者,将其按1:1随机分为试验组和对照组。治疗组给予溃结方1剂加生理盐水60ml,保留灌肠1小时,于每晚睡前一次;对照组给予美沙拉嗪灌肠液60ml,保留灌肠1小时,于每晚睡前一次。8周为一个疗程。从此治疗开始(0天)至此治疗结束(8周),共3次访视。进行临床症状体征观察,测定及血、尿、粪常规等安全性检测,待治疗结束后评价其临床疗效和安全性。结果:治疗前后两组患者在性别、年龄、病情方面差异无统计学意义,具有可比较性。治疗后两组患者症状评分,在里急后重、腹痛、溲赤、口干口苦等方面,两组间比较有明显差异(P0.05),试验组优于对照组;在安全性评价方面,试验组与对照组均无明显不良反应。结论:溃结方灌肠治疗能明显缓解大肠湿热型溃疡性结肠炎的症状、减轻腹痛、里急后重等不适感,即在改善大肠湿热型溃疡性结肠炎症状方面卓有成效,值得在临床方面做更进一步推广。
[Abstract]:Background: modern life changes with each passing day, material living standard has been improved, and diagnostic technology has been improved. What changes with it is that the incidence of UC is increasing year by year in our country. As the range of UC lesions is more extensive than other diseases, it is easy to repeat attacks, often unhealed for a long time, and the possibility of canceration is great. Therefore, the patients have been troubled by this for a long time. However, the effect of modern medicine on its treatment is not satisfactory. The World Health Organization has recognized it as a refractory disease. The recurrence of ulcerative colitis has become a worldwide problem, and it is economical and practical to use traditional Chinese medicine to treat it. Objective: to observe and summarize the improvement and clinical effect of Kuijie prescription enema in treating ulcerative colitis of large intestine damp-heat type. According to the principle of control, 100 cases of ulcerative colitis of large intestine damp-heat type were selected from inpatients and outpatients of Shanxi traditional Chinese Medicine Hospital. The experimental group was randomly divided into experimental group and control group according to 1:1. The treatment group was given Kuijie prescription 1 dose plus normal saline 60 ml, retention enema for 1 hour, once a night before bedtime, the control group was given 60 ml mesalazine enema for 1 hour, and the control group was given 60 ml mesalazine enema for 1 hour. A course of 8 weeks before going to bed every night. From then on, the treatment began for 0 days.) at the end of 8 weeks of treatment, 3 visits were made. The clinical symptoms and signs were observed, and the safety of blood, urine, fecal routine, and so on were measured. Results: there was no significant difference in sex, age and condition between the two groups before and after treatment. The difference between the two groups was significant (P 0.05). The experimental group was superior to the control group, and the safety evaluation was better than that in the control group. Conclusion: Kuijiefang enema can relieve the symptoms of ulcerative colitis of damp-heat type of large intestine, relieve abdominal pain, and relieve the discomfort after acute and severe colitis. It is effective in improving the symptoms of colonic damp-heat ulcerative colitis, and it is worth further popularizing in clinic.
【学位授予单位】：山西中医学院
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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