祛瘀解毒法对子宫内膜异位症患者腹腔液IL-6、IL-13的影响

发布时间：2018-04-04 10:21

  本文选题：子宫内膜异位症　切入点：血瘀蕴毒　出处：《辽宁中医杂志》2017年05期

【摘要】：目的:观察祛瘀解毒法治疗中医辨证血瘀蕴毒型子宫内膜异位症的临床疗效。方法:按照队列研究设计,筛选31例未服用祛瘀解毒方而直接经腹腔镜手术确诊的血瘀蕴毒型子宫内膜异位症(对照组31例),34例前期服用祛瘀解毒方而随后经腹腔镜手术确诊的血瘀蕴毒型子宫内膜异位症(观察组34例),同期筛选15例因不明原因性不孕症而行腹腔镜手术探查,未见盆腔明显异常的患者(空白组15例)。将观察组按照前期服用祛瘀解毒方时间长度,分为1个月、2个月、3个月、4个月、5个月、6个月组,比较各组患者腹腔镜手术中收集腹腔液中的IL-6、IL-13水平。结果:空白组腹腔液中IL-6浓度(20.73±9.86)pg/m L,低于观察组(106.83±34.64)pg/m L和对照组(125.04±49.53)pg/m L,差异有统计学意义(P0.05)。观察组腹腔液中IL-6浓度低于对照组,差异有统计学意义(P0.05)。空白组腹腔液中IL-13浓度(9.51±4.37)pg/m L,高于观察组(4.52±3.24)pg/m L和对照组(3.96±2.01)pg/m L,差异有统计学意义(P0.05)。观察组腹腔液中IL-13浓度,高于对照组,差异有统计学意义(P0.05)。观察组1个月、2个月、3个月、4个月、5个月、6个月组IL-6浓度(pg/m L),分别为115.05±73.19、113.80±67.39、86.83±31.65、98.47±43.58、119.52±60.37、107.31±57.49,1个月组高于另外5个组,差异有统计学意义(P0.05)。3、4个月组低于2、5、6个月组,差异有统计学意义(P0.05)。3、4个月组,组间比较差异无统计学意义(P0.05);2、5、6个月组,组间比较差异无统计学意义(P0.05)。观察组1个月、2个月、3个月、4个月、5个月、6个月组IL-13浓度(pg/m L),分别为4.33±3.17、5.39±4.73、5.08±4.03、4.05±2.32、3.79±2.19、4.48±3.71,2、3个月组高于1、4、5、6个月组,差异有统计学意义(P0.05)。2、3个月组,组间比较差异无统计学意义(P0.05);1、4、5、6个月组,组间比较差异无统计学意义(P0.05)。结论:祛瘀解毒法可影响中医辨证为血瘀蕴毒型子宫内膜异位症患者腹腔液IL-6、IL-13水平,通过抑制非特异性炎症的病理生理机制,改善子宫内膜异位症患者盆腔微环境,可能是治疗中医辨证为血瘀蕴毒型子宫内膜异位症的有效方法。
[Abstract]:Objective: to observe the clinical effect of removing blood stasis and detoxification in treating endometriosis with syndrome differentiation of blood stasis and toxin.Methods: according to the design of cohort study,Screening 31 cases of endometriosis with blood stasis and toxin accumulation which were diagnosed by laparoscopy without taking Quyu jiedu recipe (control group 31 cases were treated with Quyu jiedu recipe and then confirmed by laparoscopic surgeryEndometriosis (34 cases in the observation group, 15 cases in the same period were selected for laparoscopy because of unexplained infertility),There was no obvious abnormality in pelvic cavity (15 cases in blank group).Results: the concentration of IL-6 in peritoneal fluid of blank group was 20.73 卤9.86)pg/m L, which was lower than that of observation group (106.83 卤34.64)pg/m / L) and control group (125.04 卤49.53)pg/m / L). The difference was statistically significant (P 0.05).The concentration of IL-6 in the peritoneal fluid in the observation group was lower than that in the control group, and the difference was statistically significant (P 0.05).The concentration of IL-13 in peritoneal fluid of blank group was 9.51 卤4.37)pg/m / L, which was higher than that of observation group (4.52 卤3.24)pg/m / L) and control group (3.96 卤2.01)pg/m / L). The difference was statistically significant (P 0.05).The concentration of IL-13 in the peritoneal fluid in the observation group was higher than that in the control group, and the difference was statistically significant (P 0.05).瑙傚療缁，

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