益气降浊汤对冠心病不稳定型心绞痛患者MMPs的影响

发布时间：2018-04-04 15:29

  本文选题：益气降浊汤　切入点：冠心病　出处：《黑龙江中医药大学》2016年硕士论文

【摘要】：目的：观察益气降浊汤治疗冠心病不稳定型心绞痛痰阻心脉证的临床应用效果以及对基质金属蛋白酶的影响。方法：本试验严格遵循纳入及排除准则,共入组西医诊断为UA,中医辨证分型为痰阻心脉的患者60位,而后随机抽取,将60例患者分为对照组30例和治疗组30例,对照组给予常规治疗4周,治疗组在上述基础上加用益气降浊汤,将结果记录并进行分析。结果：对胸痹症状的疗效进行观察,治疗组与对照组的胸痹症状疗效、心绞痛疗效、心电图疗效无显著差异(P0.05)；两组疗前中医证候积分分别为16.97±4.53、16.52±4.12,治疗后分别为9.13±2.47、10.93±2.85,差异显著(P0.05)；对治疗前后主症(胸痛、胸闷)、次症(心悸、气短、胁痛、唇紫)的变化比较分析,两组胸痛、胸闷等主症差异不明显(P0.05),心悸、气短、胁痛等症差异明显(P0.05),唇紫差异不明显(P0.05);对MMP s进行比较,MMP-1、MMP-2、MMP-3组间进行比对,对照组与治疗组差异十分显著(P0.05)。疗程结束后4周随访复发率,治疗组复发率低于对照组,两组差异不显著。结论：1益气降浊汤能够显著改善UA患者中医证候2益气降浊汤可以显著降低血清中的MMP-1,MMP-2、 MMP-3,MMPs参与UA的病理进程,益气降浊汤可能通过调节MMPs发挥其稳定斑块的作用。
[Abstract]:Objective: to observe the clinical effect of Yiqi Jiangzhuo decoction (YQJD) in treating unstable angina pectoris of coronary heart disease with phlegm blocking heart pulse syndrome and its effect on matrix metalloproteinases.Methods: in this study, the criteria of inclusion and exclusion were strictly followed, 60 patients were diagnosed as UAA by western medicine, and 60 patients were divided into control group (n = 30) and treatment group (n = 30).The control group was treated with routine therapy for 4 weeks, the treatment group was treated with Yiqi Jiangzhuo decoction on the above basis, the results were recorded and analyzed.Results: the curative effect of chest arthralgia and angina pectoris were observed in the treatment group and the control group.蹇冪數鍥剧枟鏁堟棤鏄捐憲宸�寮�(P0.05);涓ょ粍鐤楀墠涓�鍖昏瘉澹�

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