基于数据挖掘刘尚义教授治疗肾癌的临床用药规律

发布时间：2018-04-05 05:06

本文选题：国医大师　切入点：刘尚义教授　出处：《辽宁中医杂志》2017年07期

【摘要】：目的:应用中医传承辅助软件数据挖掘技术对"国医大师"刘尚义教授治疗肾癌的临床用药特点进行探讨。方法:将2014年1月—2015年7月就诊于刘尚义教授国医堂门诊的120例肾癌患者信息输入系统中,对患者的用药频次进行描述统计,采用关联规则阿Apriori算法、复杂系统熵聚类等无监督数据挖掘方法,探讨刘尚义教授治疗肾癌的用药规律。结果:共涉及药物116味,使用频次在24次以上的药物有12味,其中前3位分别是鳖甲(119)、莪术(118)、冬凌草(106)。频次24以上的药物中,药性前3位依次为温、微寒、微温;药味前3位依次为甘、辛、苦。归经前3位依次为肝、肾、肺。药物组合频次出现58次以上的有25个组合,排在前4位的分别是"莪术、鳖甲"(118),"鳖甲、冬凌草"(106),"莪术、冬凌草"(105),"莪术、鳖甲、冬凌草"(105)。经聚类分析,得到10个核心药物组合和5个新方。结论:挖掘出刘尚义教授治疗肾癌的常用频次较高的药物及药物组合,并从中反映了刘尚义教授治疗肾癌的病机疗法。
[Abstract]:Objective: to explore the clinical characteristics of professor Liu Shangyi in the treatment of renal cell carcinoma (RCC).Methods: from January 2014 to July 2015, 120 patients with renal cell carcinoma were selected from Professor Liu Shangyi Medical College outpatient clinic. The frequency of drug use was described and counted, and the association rule A Apriori algorithm was used.Unsupervised data mining methods such as entropy clustering of complex systems were used to explore the rule of drug use by Professor Liu Shangyi in the treatment of renal cell carcinoma.Results: 116 kinds of drugs were involved, 12 of which were used more than 24 times, the first 3 were Biejiajiao (119D), Curcuma (118A) and oridox (106D).Among the drugs with frequency above 24, the first 3 places were temperature, mild cold and mild temperature, and the top 3 of medicinal taste were Gan, Xin and bitter in turn.Liver, kidney and lung were the first three places of meridian meridian.There were 25 combinations with more than 58 drug combinations. The top 4 groups were "Curcuma, Biejia" (118N), "Biejia, ornithia" (106N), "Curcuma (Rhizoma Curcumae)", "oridox" ("Rhizoma ornidis"), "Curcuma (Rhizoma Curcumae)", "Biejia (Biejia)", "Torinia chinensis" (1055).By cluster analysis, 10 core drug combinations and 5 new prescriptions were obtained.Conclusion: the commonly used drugs and drug combinations of Professor Liu Shangyi in the treatment of renal cell carcinoma were excavated and reflected the pathogenesis of Professor Liu Shangyi in the treatment of renal cell carcinoma.
【作者单位】：贵阳中医学院硕士研究生;贵阳中医学院第一附属医院;中国中医科学院博士后科研流动站;
【基金】：国家自然科学基金项目(81460697) 贵州省科技支撑计划项目(黔科合SY字[2013]3026号,[2014]3008-1号,[2014]3026号,[2015]3028-4,[2015]3028-5) 贵州省中医药管理局项目(QZYY-2014-041,2014-019,2015-007,2015-009,2015-028) 贵州省科技厅(黔科合人才(2016)4032号,黔科合LH字([2015]7802号)
【分类号】：R249;R273

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