肾气虚证患者认知功能改变临床特征研究

发布时间：2018-04-06 07:36

本文选题：肾气虚证　切入点：认知功能　出处：《中华中医药学刊》2017年11期

【摘要】：目的:探讨肾气虚证患者认知功能改变的临床特征。方法:对符合肾气虚证诊断标准的受试者18例和健康受试者17例分别进行临床记忆量表、威斯康星卡片分类(WCST)和连续操作测验(CPT)测验,评估其记忆功能、执行功能和注意力。结果:(1)肾气虚组的记忆商(MQ)(P=0.000)、指向记忆(P=0.000)、联想学习(P=0.002)、图像自由回忆(P=0.005)、无意义图像再认(P=0.009)和人像特点联想记忆(P=0.006)均低于对照组,差异显著;(2)WCST检测结果显示两组在总应答时间(P=0.000)、总应答数(P=0.000)、错误应答数(P=0.000)和完成第一分类所需应答数(P=0.016)四个方面存在差异;(3)CPT检测结果显示,两组在2位数上的错误反应数(P=0.046)、正确反应数(P=0.001),3位数上的正确反应数(P=0.002)、平均反应时(P=0.000)、反应时变化(P=0.005),4位数上的正确反应数(P=0.000)、平均反应时(P=0.007)上存在差异。结论:肾气虚证患者认知功能水平在记忆功能、执行功能和注意力上低于对照组,补肾或可改善患者的认知功能。
[Abstract]:Objective: To investigate the clinical characteristics of patients with deficiency of kidney function changes in cognitive. Methods: according to the diagnostic standard of kidney qi deficiency 18 subjects and 17 healthy subjects were clinical memory scale, Wisconsin card sorting (WCST) and continuous performance test (CPT) test, to evaluate the function of memory, executive function and attention. Results: (1) kidney qi deficiency group memory quotient (MQ) (P=0.000), the direct memory (P=0.000), associative learning (P=0.002), (P=0.005) image free recall, recognition meaningless (P=0.009) and portrait character associative memory (P=0.006) were lower than the control group, the difference was significant; (2) WCST test results showed that the two groups in the total response time (P=0.000), overall response (P=0.000), error responses (P=0.000) and the completion of the first classification required responses (P=0.016) in four aspects of the differences; (3) CPT test results showed that the two groups in the 2 digits on the wrong reaction the number of (P=0.046 ), the number of correct response (P=0.001), 3 digits on the number of correct response (P=0.002), the average response time (P=0.000), reaction time (P=0.005), change 4 digits on the number of correct responses (P=0.000), the average response time (P=0.007) differences. Conclusion: the level of cognitive function in patients of kidney deficiency in the memory, executive function and attention is lower than the control group, or kidney can improve the cognitive function of patients.

【作者单位】：首都医科大学附属北京安定医院国家心理疾病临床医学研究中心北京脑重大疾病研究院精神分裂症研究所精神疾病诊断与治疗北京市重点实验室北京市中西医结合精病卫生研究所;北京市通州区潞城镇社区卫生服务中心;北京中医药大学东直门医院;
【基金】：国家中医管理局2012全国名老中医药专家传承工作室建设项目[国中医药人教函(2012)149号] 国家临床重点专科(中医专业)建设项目(2100299) 北京市自然科学基金项目(7152069) 北京中医药科技发展基金项目(QN2015-15) 首都医科大学基础与临床合作基金项目(16JL84)
【分类号】：R24

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