补肾调经汤治疗肾虚型月经先后不定期的临床研究

发布时间：2018-04-08 08:40

本文选题：月经先后不定期　切入点：肾虚证　出处：《山东中医药大学》2016年硕士论文

【摘要】：目的:观察补肾调经汤治疗肾虚型月经先后不定期的临床疗效,以期确立治疗月经先后不定期的有效方法,并初步探讨其作用机理,为临床提供理论基础。方法:将门诊收集的60例肾虚型月经先后不定期的患者随机分为治疗组和对照组,每组各30例。一个疗程后(即三个月经周期)观察对比两组治疗前后临床症状及体征变化;中医证候改善程度及积分变化;促卵泡激素(FSH)、促黄体生成素(LH)、雌二醇(E2)、基础体温(BBT)及子宫内膜变化。结果:1.临床疗效比较:治疗组总有效率为93.33%,对照组总有效率为66.67%,组间比较差异有统计学意义,治疗组优于对照组(P0.05)。2.中医证候改善情况比较:治疗组总有效率96.67%,对照组总有效率73.33%,两组对比差异有统计学意义(P0.05)。3.中医证候积分比较:治疗后,治疗组与对照组积分均较治疗前降低,差异具有统计学意义,治疗组与对照组比较差异具有统计学意义(P0.05)。4.中医单项症状比较:治疗后,治疗组在改善各项中医症状方面总有效率高于对照组,组间比较差异有统计学意义(P0.05)。5.实验室检查结果及BBT变化情况比较:治疗后,治疗组FSH、LH与治疗前相比下降,差异有统计学意义(PO.05);对照组FSH、LH、E2与治疗前相比,差异无统计学意义(P0.05)。治疗后,两组FSH、LH组间比较,差异有统计学意义(P0.05)。治疗后两组子宫内膜厚度与治疗前比较差异有统计学意义(P0.05),治疗组与对照组对比,差异有统计学意义(P0.05)。治疗后基础体温两组对比,差异有统计学意义(P0.05)。结论:补肾调经汤治疗肾虚型月经先后不定期,可以更好的改善患者的临床症状及体征、FSH及LH、BBT、子宫内膜厚度。其作用机制可能与调节机体下丘脑-垂体-卵巢轴有关。补肾调经汤治疗肾虚型月经先后不定期临床效果满意,并且安全可靠。
[Abstract]:Objective: to observe the clinical effect of Bushen Tiaojing decoction on menstruation of kidney deficiency type, to establish an effective method of treating menstrual disorder, and to explore its mechanism, and to provide a theoretical basis for clinical practice.Methods: sixty patients with kidney deficiency menstruation were randomly divided into treatment group and control group, 30 cases in each group.After a course of treatment (that is, three menstrual cycles), the changes of clinical symptoms and signs before and after treatment, the degree of improvement of TCM syndromes and the changes of integral were observed and compared between the two groups.Follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E 2), basal body temperature (BBT) and endometrial changes.The result is 1: 1.Comparison of clinical efficacy: the total effective rate of the treatment group was 93.33 and the total effective rate of the control group was 66.67. The difference between the two groups was statistically significant, and the treatment group was superior to the control group (P 0.05).Comparison of the improvement of TCM syndromes: the total effective rate in the treatment group was 96.677.The total effective rate in the control group was 73.33. The difference between the two groups was statistically significant.Comparison of TCM syndromes: after treatment, the scores of the treatment group and the control group were lower than those of the control group, the difference was statistically significant, and the difference between the treatment group and the control group was statistically significant.Comparison of single symptoms of TCM: after treatment, the total effective rate of the treatment group in improving the symptoms of traditional Chinese medicine was higher than that of the control group, and the difference between the two groups was statistically significant (P 0.05).Comparison of the results of laboratory examination and the changes of BBT: after treatment, the FSH LH in the treatment group was lower than that before treatment, the difference was statistically significant (P 0.05), while in the control group, there was no significant difference between the two groups before and after treatment (P 0.05).After treatment, the difference between the two groups was statistically significant (P 0.05).There was a significant difference in endometrial thickness between the two groups after treatment and before treatment (P 0.05), and the difference between the treatment group and the control group was statistically significant (P 0.05).There was a significant difference in basic body temperature between the two groups after treatment (P 0.05).The mechanism may be related to the regulation of hypothalamus-pituitary-ovary axis.The treatment of kidney deficiency menstruation with Bushen Tiao Jing decoction has satisfactory clinical effect and is safe and reliable.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R271.11

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