清开灵注射液治疗病毒性肝炎引起肝功能异常的Meta分析

发布时间：2018-04-09 09:10

本文选题：清开灵注射液　切入点：有效率　出处：《中成药》2017年06期

【摘要】：目的清开灵注射液在临床实践中常用于治疗病毒性肝炎,但缺乏一定的循证医学依据。本研究采用Meta分析方法以期评价其在临床应用的有效性和安全性。方法计算机检索CNKI(相关期刊论文)、VIP(中文科技期刊数据库)和万方数据库1996—2016年期间发表的有关清开灵注射液静脉注射治疗病毒性肝炎的临床随机对照研究,采用Rev Man5.3软件对清开灵注射液的有效率、不良反应率、ALT(谷丙转氨酶)下降率、AST(谷草转氨酶)下降率以及TBIL(总胆红素)下降率进行Meta分析,同时对剂量[0.5 mL/(kg·d)、0.5~0.67 mL/(kg·d)、0.67 mL/(kg·d)]、疗程(≤14 d、14 d)、厂家(北京中医药大学药厂、神威药业、山西太行药业)、年份(1996—2002、2003—2009、2010—2016)的有效率进行亚组分析。结果根据纳入和排除标准纳入文献14篇。Meta分析结果显示,其总有效率、ALT、AST和TBIL指标的下降率均明显高于对照组(P0.05),而其不良反应发生率与对照组相比无显著差异(P0.05);亚组分析结果显示,不同剂量、不同疗程、不同厂家以及不同使用年份,其中的清开灵注射液治疗组的有效率均明显高于对照组(P0.05)。结论清开灵注射液治疗病毒性肝炎具有明显的疗效,能降低患者ALT、AST活性和TBIL含有量。但其临床使用时应注意预防过敏样反应的发生。
[Abstract]:Objective Qingkailing injection is often used to treat viral hepatitis in clinical practice, but it lacks evidence-based medicine.The purpose of this study was to evaluate the efficacy and safety of Meta analysis in clinical application.Rev Man5.3 software was used to analyze the effective rate and adverse reaction rate of Qingkailing injection and the decrease rate of alt (alanine aminotransferase) and total bilirubin (TBIL) by Meta.Results according to the inclusion and exclusion criteria, 14 references were included. Meta-analysis showed that,The decrease rate of the total effective rate of alt AST and TBIL was significantly higher than that of the control group (P 0.05), but the incidence of adverse reactions was not significantly different from that of the control group (P 0.05). The results of subgroup analysis showed that different doses, different courses of treatment, different manufacturers and different years of use,The effective rate of Qingkailing injection treatment group was significantly higher than that of control group (P 0.05).Conclusion Qingkailing injection is effective in the treatment of viral hepatitis and can reduce the activity of alt and the content of TBIL.However, attention should be paid to the prevention of allergic reactions in clinical use.
【作者单位】：上海中医药大学药物安全评价研究中心;
【基金】：国家“十二五”科技重大专项课题(2011ZX09301-009)
【分类号】：R259

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