从脾论治相关疾病的数据库构建以及文献分析挖掘

发布时间：2018-04-13 05:21

本文选题：脾 + 文献研究　；参考：《辽宁中医药大学》2017年硕士论文

【摘要】：研究目的:本文通过对从脾论治相关疾病的现代文献进行挖掘研究,探讨建国以来从脾论治相关疾病的宏观情况,深入分析腹泻、痞满、冠心病、紫癜的临床诊疗规律和动物实验研究内涵。研究资料与方法:以从脾论治相关疾病的现代文献作为研究资料,通过构建数据库以及数据平台,对从脾论治相关疾病现代临床类文献的病、证、症、方等内容以及动物实验类文献的病、证、指标内容进行规范,以关联分析为主进行数据挖掘和可视化处理,探讨并总结从脾治疗相关疾病的临床文献和动物实验文献的内涵规律。研究成果与结论:1结合年代和发文量分析,文献的增长情况良好,临床从脾论治相关疾病的研究一直在稳步发展。2根据宏观情况分析,从脾论治疾病涉及到中医的内、外、妇、儿以及耳鼻喉和骨伤科,中医内科疾病中脾胃系疾病、气血津液病以及肝胆病所占比例较大;从脾治疗相关疾病的西医病种在九大系统皆有所涉及,其中对消化系统,内分泌系统和循环系统疾病的治疗具有明显优势。3选取了功能性消化不良、腹泻、冠心病、紫癜进行分析,绘制力导向图,得出现代临床中的以上疾病分别和中医学中的痞满、泄泻、胸痹、紫斑和血证联系最为密切。在现代临床中,它们的最常见证型分别是“肝郁脾虚”“脾阳虚”“心脾两虚”和“脾肾两虚、阴虚火旺”,这些与现代人的生活方式有很大关系;在治疗方面,功能性消化不良中临床应用最多的方剂是桂附理中汤;腹泻(包括小儿腹泻)应用最多的方剂是参苓白术散;紫癜以及冠心病临床应用最多的方剂是归脾汤。以上四种疾病,胸痹、泄泻、痞满的共有证型是肝郁脾虚,而紫斑与泄泻证型联系最为密切,共有证型是脾肾两虚。4对功能性消化不良、腹泻、冠心病、紫癜的动物实验类文献进行研究,绘制桑基图,得出了从脾论治冠心病主要是从气与血的异常出发,其病理产物是痰与瘀,与现代医学的能量代谢、脂质代谢、免疫反应以及血管壁张力内容有关;紫癜主要的发生机制是脾统血功能的失常,与现代医学的血液组成物质、血管生理功能以及人体的免疫机制有关;腹泻和功能性消化不良都是由于脾的运化功能失常造成的,它们与现代医学中的胃肠运动激素、脑-肠轴和免疫系统等相关指标均有密切联系。以上四种疾病皆可根于脾虚,其中腹泻与消化不良的发生根于脾的运化失司;紫癜的发生源于脾不统血;冠心病的发生是脾运化与统血功能异常共同作用的结果。
[Abstract]:Objective: to explore the macroscopical situation of the diseases related to spleen treatment since the founding of the people's Republic of China, and to analyze the diarrhea, fullness, coronary heart disease by digging up the modern literature on the treatment of diseases related to spleen.Clinical diagnosis and treatment of purpura and connotation of animal experiment.Research materials and methods: taking the modern literature on the treatment of related diseases from the spleen as the research data, through constructing the database and data platform, the diseases, syndromes and symptoms of the modern clinical literature on the treatment of the related diseases from the spleen were studied.Fang and other contents, as well as the disease, syndrome and index contents of animal experimental literature, are standardized, and data mining and visualization are mainly carried out by association analysis.To explore and summarize the connotation of clinical literature and animal experimental literature on spleen treatment related diseases.Research results and conclusions: 1 combined with the analysis of the years and the quantity of documents issued, the growth of the literature is good. The research on the clinical treatment of diseases related to the treatment of the spleen has been developing steadily .2 according to the macroscopic analysis, the treatment of diseases by the spleen involves the internal, external and female aspects of traditional Chinese medicine.Children, otolaryngology and orthopedics, diseases of spleen and stomach, diseases of qi, blood and body fluid, and diseases of liver and bile in traditional Chinese medicine have a large proportion. Western medicine diseases related to the treatment of spleen and spleen are involved in nine major systems, among which are the digestive system.The treatment of endocrine system and circulatory system diseases has obvious advantage. .3 selected functional dyspepsia, diarrhea, coronary heart disease, purpura to carry on analysis, draw force guide chart, get the above diseases in modern clinic and bulge full in traditional Chinese medicine, respectively.Diarrhea, chest obstruction, purple spots and blood syndrome are most closely linked.In modern clinical practice, their most common syndromes are "liver stagnation and spleen deficiency," "spleen Yang deficiency," "deficiency of heart and spleen," and "deficiency of spleen and kidney, deficiency of yin and fire", which are closely related to modern life style.The most commonly used prescription in functional dyspepsia is Guifulizhong decoction; the most commonly used prescription for diarrhea (including infantile diarrhea) is Shenling Atractylodes Powder; the prescription for purpura and coronary heart disease is Guipi decoction.The common syndromes of the above four diseases, chest obstruction, diarrhea, and fullness, are liver stagnation and spleen deficiency, while purple spot is most closely related to diarrhea syndrome. The common syndrome type is functional dyspepsia, diarrhea, coronary heart disease with deficiency of spleen and kidney.The animal experimental literature of purpura was studied, and the mulberry map was drawn. It was concluded that the treatment of coronary heart disease from spleen was mainly based on the abnormality of qi and blood, and its pathological product was phlegm and blood stasis, energy metabolism and lipid metabolism in modern medicine.The main mechanism of purpura is the abnormal function of spleen regulating blood, which is related to the blood composition of modern medicine, the physiological function of blood vessel and the immune mechanism of human body.Diarrhea and functional dyspepsia are caused by splenic dysfunctions which are closely related to gastrointestinal motility hormones brain-intestinal axis and immune system in modern medicine.The above four diseases can be rooted in spleen deficiency, in which diarrhea and dyspepsia take root in the spleen, purpura comes from spleen not regulating blood, and coronary heart disease is the result of splenic translocation and abnormal function of blood regulation.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：G250.74;R259

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