“三才益智”灸法治疗轻度认知障碍的临床疗效评价

发布时间：2018-04-13 17:44

本文选题：轻度认知障碍 + 三才益智　；参考：《成都中医药大学》2016年硕士论文

【摘要】：目的：本研究以传统的“三才”思维模型作为基本指导思想,结合窦汉卿三才穴的组方选穴特点及轻度认知障碍(Mild Cognitive Impairment, MCI)的中医发病基础和基本病机,精选百会、神阙和涌泉穴同时施以“三才益智”灸法治疗MCI并评价其临床疗效和安全性,为艾灸治疗MCI的临床运用提供进一步的科学证据。方法：采用完全随机对照的临床研究方法,将符合试验研究纳入标准的80例MCI患者随机分配到灸法组和药物组。按照不同的治疗方案,灸法组采用艾灸百会、神阙和涌泉穴,隔日一次,共治疗8周。药物组口服尼莫地平30mg/次,1次/日,连续服用8周。以简易精神状态检查(The Mini-Mental Status Examinination, MMSE)、临床记忆量表(Clinical Memory Scale, CMS)无意义图形再认评分和画钟测验(Clock Drawing Test, CDT)为疗效评价指标,分别于治疗前和治疗2个月后,对两种治疗方案治疗MCI进行临床疗效和安全性的评价。结果：1、两组受试者分组均衡,基线一致,可比性好。2、MMSE量表评价结果：“三才益智”灸法组MMSE量表的总分较治疗前有极显著提高(P0.01)其中回忆力、语言能力等项积分治疗后较治疗前有极显著统计学差异(P0.01)注意力和计算力积分治疗后较治疗前有统计学差异(P0.05)。但是,治疗两个月后,灸法组和药物组患者的MMSE量表总分、定向力、记忆力、注意力和计算力、回忆力及语言能力等各项积分的组间比较,均没有统计学差异(P0.05)。3、CMS无意义图形再认评价结果：“三才益智”灸法组CMS无意义图形再认的评分较治疗前有极显著差异(P0.01),但灸法组和药物组疗效的组间比较差异无统计学意义(P0.05)4、CDT评价结果：“三才益智”灸法组CDT的评分较治疗前有极显著差异(P0.01),但灸法组和药物组疗效的组间比较差异无统计学意义(P0.05)。结论：“三才益智”灸法能发挥改善MCI患者的综合认知功能的作用,且安全性较好,但尚不能确定“三才益智”灸法和尼莫地平之间的优越性。
[Abstract]:Objective: this study took the traditional "three talents" thinking model as the basic guiding ideology, combined with the characteristics of the prescription selection of the Sancai point of Dou Hanqing and the milder Cognitive Impairment (MCIs), selected the basic pathogenesis and pathogenesis of traditional Chinese medicine.Shenque and Yongquan were treated with "three talents" moxibustion to treat MCI and evaluate its clinical efficacy and safety, which provided further scientific evidence for clinical application of moxibustion in treating MCI.Methods: 80 patients with MCI were randomly assigned to moxibustion group and drug group.According to different treatments, moxibustion group was treated with moxibustion at Baihui, Shenque and Yongquan every other day for 8 weeks.The drug group was given nimodipine 30mg/ once a day for 8 weeks.The Mini-Mental Status examination, the Clinical memory scale and Clinical Memory scale (CMSS) were used to evaluate the efficacy of the Mini-Mental Status examination and clock Drawing Test (CDTs) before and after 2 months of treatment, respectively.To evaluate the clinical efficacy and safety of two treatment regimens for MCI.Results: one, two groups of subjects were divided into balanced groups, the baseline was the same, and the evaluation results of MMSE scale were good. 2The total score of MMSE scale in the moxibustion group of "Sancai Yizhi" moxibustion method was significantly higher than that before treatment (P 0.01).After treatment, there was a significant statistical difference in the score of language ability between before and after treatment. (P0.01) there was a significant difference in attention and computational power after treatment and there was a significant difference between the two groups before and after treatment (P 0.05).However, after two months of treatment, the scores of total score of MMSE scale, orientation, memory, attention and calculation, recall ability and language ability of patients in moxibustion group and drug group were compared.There was no statistical difference between the two groups. There was no significant difference in the scores of CMS meaningless pattern recognition between the "Sancai Yizhi" moxibustion group and the pre-treatment group, but there was no significant difference between the moxibustion group and the drug group in the efficacy of the moxibustion group.There was significant difference in CDT score between Sancai Yizhi moxibustion group and pre-treatment group (P 0.01), but there was no significant difference between moxibustion group and drug group (P 0.05).Conclusion: Sancai Yizhi moxibustion can improve the comprehensive cognitive function of MCI patients, and the safety is good, but the superiority between Sancai Yizhi moxibustion and nimodipine can not be determined.
【学位授予单位】：成都中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R246.6

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