寻常型银屑病中医辨治新体系与经典体系疗效对比研究

发布时间：2018-04-13 20:08

本文选题：寻常型银屑病 + 中医辨治　；参考：《河南中医药大学》2016年硕士论文

【摘要】：目的:通过对新的证治体系与经典的证治体系的疗效差异的大样本观察,总结出更客观、更有效的银屑病治疗体系,提高寻常型银屑病的辨证与治疗水平。方法:本项目采用前瞻性、大样本、随机平行对照的临床试验设计,大样本观察新的证治体系与经典的证治体系的疗效差异。拟纳入寻常型银屑病患者300例,病例资料均来自于2014年10月至2015年12月我科门诊,随机分为新体系辨证治疗组和经典体系对照组。新体系辨证治疗组严格按照新体系进行辨证用药(详见表2新体系具体处方用药标准),给予相应中药免煎颗粒,每日一剂,分早晚两次饭后温服;经典体系辨证治疗组严格按照经典体系辨证用药(详见表1经典体系具体处方用药标准),给予相应中药免煎颗粒,每日一剂,分早晚两次饭后温服。所有纳入患者均外用卡泊三醇软膏和糠酸莫米松软膏混合外涂,每日早晚两次抹。采用国际公认的PASI评分标准和国内权威的疗效评定标准进行客观的疗效评价,运用spass19.0统计软件进行统计分析。新体系辨证治疗组和经典体系辨证治疗组的平均年龄比较用独立样本t检验,性别比较用χ2检验,初诊pasi评分比较用独立样本t检验,最后对两组疗效差异比较用χ2检验,从临床、安全性等方面客观评价两组疗效的差异。结果:两组疗效结果在治疗2、4、6、8周后进行评估,疗效评价时,治愈与显效病例合计为有效病例,计算有效率。其中新体系治疗组予2、4、6、8周时有效率分别是16.67%、42.36%、72.22%、89.58%;经典体系治疗组予2、4、6、8周时有效率分别是2.08%、4.86%、15.28%、53.47%;两组疗效经χ2检验结果2、4、6、8周P值均是P0.05,差异有统计学意义,又加上各时间节点新体系治疗组有效率均高于经典体系治疗组有效率,所以新体系治疗组疗效优于经典体系治疗组疗效。结论:临床试验证明新的证治体系疗效优于经典的证治体系。
[Abstract]:Objective: to summarize a more objective and effective psoriasis treatment system by observing the difference of therapeutic effect between the new syndrome system and the classical one, and to improve the level of syndrome differentiation and treatment of psoriasis vulgaris.Methods: a prospective, large sample, randomized, parallel control clinical trial design was used to observe the difference of therapeutic effect between the new syndrome and treatment system and the classical treatment system.A total of 300 patients with psoriasis vulgaris were included. The data were collected from October 2014 to December 2015. They were randomly divided into two groups: the new system syndrome differentiation treatment group and the classical system control group.The new system syndrome differentiation treatment group strictly according to the new system according to the new system for the treatment of syndrome differentiation (see Table 2, the new system specific prescription drug standard, given the corresponding Chinese medicine free decoction granules, one dose daily, divided into morning and evening twice after the meal warm clothes;The treatment group of classic syndrome differentiation was strictly in accordance with the classic system. (for details, see Table 1, the specific prescription standard of the classic system, give the corresponding Chinese medicine free decoction granules, one dose daily, divided into morning and evening, two times after meal warm clothes.All patients were treated externally with carpotriol ointment and momethasone furoate ointment twice a day.The objective evaluation of curative effect was carried out by using the internationally accepted PASI scoring standard and the domestic authoritative evaluation standard of curative effect, and the statistical analysis was carried out by using the spass19.0 statistical software.The average age of the new system syndrome differentiation treatment group and the classical system syndrome differentiation treatment group were compared by independent sample t test, sex comparison by 蠂 2 test, pasi score by independent sample t test, and the difference of curative effect between the two groups by 蠂 2 test.Objective evaluation of the two groups from clinical, safety and other aspects of the difference in efficacy.Results: the results of the two groups were evaluated after 8 weeks of treatment. In the evaluation of curative effect, the cases of cure and obvious effect were all effective cases, and the effective rate was calculated.The effective rates of the new system treatment group at 8 weeks were 16.67 and 42.36 and 72.22 and 89.58, respectively; the effective rates of the classical system treatment group at 8 weeks were 2.08 and 4.86, 15.28 and 53.47, respectively. The results of 蠂 2 test showed that the effective rates of the two groups were all P 0.05, and the difference was statistically significant.In addition, the effective rate of the new system treatment group is higher than that of the classical system treatment group, so the new system treatment group is superior to the classical system treatment group.Conclusion: the clinical trial proves that the new syndrome treatment system is superior to the classical syndrome treatment system.
【学位授予单位】：河南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R275.9

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