肛门洗剂对肛瘘术后创面恢复的影响

发布时间：2018-04-14 14:23

本文选题：肛门洗剂 + 肛瘘　；参考：《中国中西医结合杂志》2017年06期

【摘要】：目的观察肛门洗剂促进肛瘘术后创面恢复的效果。方法选取100例肛瘘术后患者,随机分为观察组和对照组,各50例。术后第2天对照组患者给予高锰酸钾熏洗,观察组患者给予肛门洗剂熏洗,连续治疗14天。比较两组患者临床疗效、症状积分、创面面积、创面愈合时间、创面纵径,同时检测转化生长因子-β1(TGF-β1)、血管内皮生长因子(VEGF)表达。结果与对照组[80%(40/50)]比较,观察组临床有效率[96%(48/50)]明显升高(χ2=6.061,P=0.014)。与本组术后1天相比较,两组患者术后7、14天时创面疼痛、创面渗出、创面水肿等症状评分均降低,TGF-β1、VEGF表达增高(P0.05),且观察组优于对照组(P0.05)。与对照组比较,观察组创面面积、创面愈合时间、创面纵径均明显减少(t=2.954、2.911、3.125,P=0.042、0.046、0.011)。结论肛门洗剂可促进肛瘘术后创面恢复,其作用可能与上调TGF-β1、VEGF表达有关。
[Abstract]:Objective to observe the effect of anal lotion on wound recovery after anal fistula.Methods 100 cases of postoperative anal fistula were randomly divided into observation group and control group, 50 cases in each group.The control group was treated with potassium permanganate on the second day after operation, and the patients in the observation group were treated with anal lotion for 14 days.The clinical efficacy, symptom score, wound area, wound healing time and wound longitudinal diameter were compared between the two groups. The expression of transforming growth factor- 尾 1 (TGF- 尾 1) and vascular endothelial growth factor (VEGF) were detected.Results compared with the control group (80 / 50), the clinical effective rate [96 / 48 / 50] in the observation group was significantly increased (蠂 ~ 2 / 6.061).Compared with 1 day after operation, the scores of pain, exudation and edema of wound were decreased in both groups, and the expression of VEGF in TGF- 尾 _ 1 was higher than that in control group (P0.05), and the observation group was superior to the control group (P 0.05).Compared with the control group, the wound area, wound healing time and the longitudinal diameter of the wound in the observation group were significantly reduced by 2.954U 2.9113.125Pu 0.042U 0.046m 0.011.Conclusion anal lotion can promote the recovery of wound after anal fistula, which may be related to the up-regulation of TGF- 尾 _ 1 VEGF expression.
【作者单位】：江西中医药大学附属医院肛肠科;
【基金】：江西省教育厅科学技术研究项目(No.GJJ14618)
【分类号】：R266

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