补肾壮筋汤治疗肝肾亏虚型膝骨关节炎的临床研究

发布时间：2018-04-14 23:27

本文选题：骨关节炎 + 膝　；参考：《风湿病与关节炎》2017年02期

【摘要】：目的:探讨补肾壮筋汤治疗肝肾亏虚型膝骨关节炎的临床疗效。方法:将220例膝骨关节炎患者随机分为治疗组和对照组,每组110例。治疗组口服补肾壮筋汤治疗,对照组口服盐酸氨基葡萄糖胶囊治疗。2组均以12周为1个疗程。观察2组及治疗前后疼痛视觉模拟评分法(VAS)评分、西安大略和麦马斯特大学(WOMAC)骨关节炎指数的变化。结果:治疗组完成101例,脱落9例;对照组完成97例,脱落13例。2组脱落率比较,差异无统计学意义(P0.05)。治疗组优22例,良45例,中20例,差14例,优良率为66.34%,总有效率为86.14%;对照组优16例,良34例,中32例,差15例,优良率为51.55%,总有效率为84.54%。治疗组优良率明显高于对照组(P0.05);2组总有效率比较,差异无统计学意义(P0.05)。治疗后,2组VAS评分与WOMAC骨关节炎指数均有明显改善(P0.01),且治疗组优于对照组(P0.05)。结论:补肾壮筋汤能有效缓解肝肾亏虚型膝骨关节炎的临床症状,改善关节功能。
[Abstract]:Objective: to study the clinical effect of Bushen Zhuangjin decoction on knee osteoarthritis with deficiency of liver and kidney.Methods: 220 patients with knee osteoarthritis were randomly divided into treatment group and control group with 110 cases in each group.The treatment group was treated with Bushen Zhuangjin decoction and the control group with glucosamine hydrochloride capsule for 12 weeks.The visual analogue pain score (VAS) and the Osteoarthritis Index (OJ) were observed in both groups and before and after treatment.Results: there were 101 cases in the treatment group, 9 cases in the control group, 97 cases in the control group and 13 cases in the control group. There was no significant difference in the rate of exfoliation between the two groups (P 0.05).In the treatment group, there were excellent 22 cases, good 45 cases, middle 20 cases, poor 14 cases, the excellent and good rate was 66.34 and the total effective rate was 86.14.The control group was excellent in 16 cases, good in 34 cases, middle in 32 cases, poor in 15 cases, the excellent and good rate was 51.55 and the total effective rate was 84.54.The excellent and good rate in the treatment group was significantly higher than that in the control group (P 0.05). The total effective rate of the treatment group was higher than that of the control group (P 0.05), and the difference was not statistically significant (P 0.05).After treatment, VAS score and WOMAC osteoarthritis index were significantly improved in both groups, and the treatment group was superior to the control group.Conclusion: Bushen Zhuangjin decoction can effectively relieve the clinical symptoms of knee osteoarthritis with deficiency of liver and kidney and improve joint function.
【作者单位】：南京军区福州总医院;潍坊市中医院;上海交通大学医学院附属第九人民医院;福州市第二医院;福建中医药大学附属第二人民医院;福建中医药大学中西医结合研究院;
【基金】：福建省自然科学基金(2016J01395) 福建省中青年教师教育科研项目新世纪优秀人才(JA14150) 福建中医药大学校管课题-科研创新平台专项(X2015021-平台)
【分类号】：R274.9

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