益气固表汤与健康管理干预肺脾气虚型RRTI的临床研究

发布时间：2018-04-15 17:04

本文选题：小儿反复呼吸道感染 + 从脾治肺　；参考：《河南中医药大学》2016年硕士论文

【摘要】：目的:客观评价国家级名老中医黄建业教授经验方“益气固表汤”联合健康管理治疗肺脾气虚型小儿反复呼吸道感染(Recurrent Respiratory Tract Infections RRTI,又叫“复感儿”)的有效性、安全性,为推广应用名老中医经验方及本病的健康管理理念奠定基础。方法:采用随机单盲对照方法,将符合诊断、纳入标准的60例患儿按1:1:1的比例分配至玉屏风颗粒组(对照组)、益气固表汤组(治疗1组)、益气固表汤+健康管理组(治疗2组),每组各20例。对照组口服玉屏风颗粒,治疗1组口服益气固表汤,治疗2组口服益气固表汤的同时给予健康管理,治疗7天为一疗程,连续治疗4个疗程;同时三组均给予穴位贴敷4次。在治疗前、治疗后第7天、第14天、第21天、28天,各观察一次,记录在病例观察表(CRF表)中。疗程结束后第6个月随访1次。采用SPSS16.0统计软件对数据进行统计分析,比较三组治疗前人口基线、疾病基线与总积分、主次症积分,评价三组治疗后疾病综合疗效、中医证候疗效、总积分、主次症与单一症候积分等等,并对部分病例治疗前后的免疫功能进行比较分析。结果:1.治疗后三组综合疗效、中医证候综合疗效比较,差异有统计学意义(P均0.05),益气固表汤组及益气固表汤+健康管理组疗效均优于玉屏风颗粒对照组。2.三组治疗第14天、21天、28天后中医证候总积分时点疗效比较,差异有统计学意义(P均0.05);益气固表汤组、益气固表汤+健康管理组与玉屏风颗粒组在治疗后时点疗效评价上,差异有统计学意义(P均0.05),即益气固表汤组及益气固表汤+健康管理组疗效较比玉屏风散颗粒组持久。4.年龄、性别、身高、体重等相关因素对本研究无影响(P均0.05)。5.三组无不良事件/反应发生。结论:益气固表汤、益气固表汤+健康管理与玉屏风颗粒组治疗肺脾气虚型反复呼吸道感染安全、有效,说明治疗RRTI时均可选用。但益气固表汤、益气固表汤+健康管理在显效率、总有效率、疗效稳定性上明显优于玉屏风颗粒。提示对RRTI患儿与家长进行健康管理,将有助于提高肺脾气虚型RRTI的有效率和疗效的持久性,益气固表汤、益气固表汤+健康管理值得推广应用。
[Abstract]:Objective: to evaluate objectively the efficacy and safety of "Yiqi Gubiao decoction" and "Yiqi Gubiao decoction" in the treatment of recurrent respiratory tract infection (Recurrent Respiratory Tract Infections RRTI) in children with deficiency of lung and spleen qi.It lays a foundation for popularizing and applying the famous Chinese medicine experience prescription and the health management idea of this disease.Methods: a randomized single-blind control method was used.The 60 children who were included in the standard were divided into two groups according to the proportion of 1:1:1: control group (control group), Yiqigubiao decoction group (treatment group 1), Yiqigubiao decoction health management group (treatment group 2, 20 cases in each group).The control group was treated with Yupingfeng granule, the treatment group was treated with Yiqi Gubiao decoction, the treatment group was given health management while the treatment group was treated with Yiqi Gubiao decoction, the treatment group was treated for 7 days as a course of treatment for 4 consecutive courses of treatment, and the three groups were all given acupoint application for 4 times at the same time.Before treatment, 7 days, 14 days, 21 days and 28 days after treatment, each observation was recorded in CRF.The patients were followed up 6 months after the course of treatment.The data were statistically analyzed by SPSS16.0 software. The population baseline, disease baseline and total score, primary and secondary symptom score were compared among the three groups before treatment, and the comprehensive curative effect, TCM syndromes and total score were evaluated after treatment in the three groups.The immune function of some cases before and after treatment were compared and analyzed.The result is 1: 1.After treatment, the three groups of comprehensive efficacy, TCM syndromes comprehensive efficacy comparison, the difference was statistically significant (P 0.05), Yiqi Gu Bao Tang and Yiqi Gu Bo Tang health management group were better than the control group of Yupingfeng granule. 2.There were significant differences between the three groups in the total time points of TCM syndromes after 14 days of treatment and 21 days after 28 days of treatment, the difference was statistically significant (P < 0.05), and that of the groups of Yiqi Gubiao decoction, Yiqigubiao decoction health management group and Yupingfeng granule group was evaluated at the time point after treatment.The difference was statistically significant (P < 0.05), that is, the curative effect of Yiqi Gubiao decoction group and Yiqigubiao decoction health management group was longer than that of Yupingfeng Powder group. 4.Age, sex, height, weight and other related factors had no effect on this study (P < 0.05).No adverse events / reactions occurred in the three groups.Conclusion: the health management of Yiqi Gubiao decoction and Yupingfeng granule group is safe and effective in the treatment of recurrent respiratory tract infection with deficiency of lung and spleen qi, indicating that it can be used in the treatment of RRTI.But the health management of Yiqi Gubiao decoction and Yiqi Gubiao decoction was superior to Yupingfeng granule in the obvious efficiency, the total effective rate and the curative effect stability.It is suggested that the health management of RRTI children and their parents will be helpful to improve the effective rate and the persistence of curative effect of RRTI. It is worth popularizing and applying the health management of Yiqi Gubiao decoction and Yiqi Gubiao decoction.
【学位授予单位】：河南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R272

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