知柏地黄汤合桃红四物汤治疗狼疮性肾炎肝肾阴虚兼血瘀证临床研究

发布时间：2018-04-16 07:21

本文选题：狼疮性肾炎 + 知柏地黄汤　；参考：《山东中医药大学》2016年硕士论文

【摘要】：目的:观察知柏地黄汤合桃红四物汤对狼疮性肾炎(LN)肝肾阴虚兼血瘀证患者的临床疗效,探讨滋阴降火辅以活血化瘀法治疗本病的优势,为进一步探讨中医药治疗LN提供一定的依据。方法:本研究收集LN肝肾阴虚兼血瘀证患者60例,随机分为2组,试验组、对照组各30例。对照组予以西医基础治疗,试验组除给予基础治疗外,加用知柏地黄汤合桃红四物汤,进行为期2个月的观察。观察并记录患者治疗前和治疗后的症状、体征,记录并比较治疗前和治疗后的中医证候积分、疾病活动度(SLE-DAI)、24h尿蛋白、C3、血沉(ESR)、肌酐(Cr)、尿素氮(BUN)、抗ds-DNA抗体、尿红细胞、血常规、肝功,然后对记录的数据进行比较、评分。比较并分析两组化验指标和不良反应等,作出疗效评价。结果:1.在临床疗效、中医证候疗效方面,对比两组,试验组效果明显,优于对照组,P0.05,有统计学意义;2.在SLE-DAI、中医证候积分方面,对比治疗前两组都有改善,P0.01,有统计学意义;两组治疗后对比,P0.05,没有统计学意义;3.在C3、血沉方面,对比两组,试验组较对照组效果明显,P0.01,有显著性差异;4.在安全性指标方面,对比两组,P均0.05,没有统计学意义;5.在不良反应方面,对比两组,P0.05,没有统计学意义。结论:知柏地黄汤合桃红四物汤治疗LN肝肾阴虚兼血瘀证患者疗效明显。可以明显改善患者的临床症状,降低血沉,升高C3,显示出了中医药治疗本病的优势。
[Abstract]:Objective: to observe the clinical effect of Zhibai Dihuang decoction and Taohong Siwu decoction on the patients with liver-kidney yin deficiency and blood stasis syndrome, and to explore the advantages of nourishing yin and reducing fire and promoting blood circulation and removing blood stasis in the treatment of this disease.In order to further explore the treatment of LN with Chinese medicine to provide certain basis.Methods: a total of 60 LN patients with liver and kidney yin deficiency and blood stasis syndrome were randomly divided into two groups: experimental group (n = 30) and control group (n = 30).The control group was treated with western medicine, the experimental group was treated with Zhibai Dihuang decoction and Taohong Siwu decoction, and the experimental group was observed for 2 months.The symptoms and signs of the patients before and after treatment were observed and recorded. The scores of TCM syndromes before and after treatment were recorded and compared. The disease activity of SLE-DAI was compared with that of 24 hours urinary protein C 3, ESR, creatinine, urea nitrogen bun, anti ds-DNA antibody, urine red blood cell, blood routine examination.Liver function, and then the recorded data were compared and scored.To compare and analyze the two groups of laboratory indexes and adverse reactions, to evaluate the curative effect.The result is 1: 1.In the clinical efficacy, TCM syndromes efficacy, compared with the two groups, the experimental group was significantly better than the control group (P 0.05), with statistical significance.In SLE-DAI, TCM syndromes integral, the two groups before treatment have improved P0.01, there is statistical significance; two groups after treatment compared with P0.05, there is no statistical significance.In C _ 3, ESR, compared with the two groups, the experimental group than the control group, the effect of P 0.01, there is a significant difference between the two groups (P 0.01).In terms of safety index, the two groups P 0.05, there is no statistical significance.There was no significant difference in adverse reactions between the two groups (P 0.05).Conclusion: Zhibai Dihuang decoction and Taohong Siwu decoction are effective in treating LN patients with deficiency of liver and kidney yin and blood stasis.It can obviously improve the clinical symptoms, reduce the erythrocyte sedimentation rate and increase C _ 3, which shows the advantage of traditional Chinese medicine in the treatment of this disease.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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