温肾解毒通络导邪法治疗消渴肾病（脾肾阳虚兼瘀毒证）的临床研究

发布时间：2018-04-17 21:02

本文选题：消渴肾病 + 脾肾阳虚兼瘀毒　；参考：《长春中医药大学》2016年硕士论文

【摘要】：目的:通过系统的临床观察研究,选择消渴肾病脾肾阳虚兼瘀毒证的患者,采用导师常用的自拟方剂补参消肾安汤的中药汤剂治疗,客观评价其临床疗效、安全性,为临床治疗消渴肾病提供一种新的思路与治疗方法。方法:选取60例长春中医药大学附属医院南征工作室门诊以及内分泌疗区的患者,采用随机的方法分为治疗组与对照组,每组各30例,作出症候分析。对所有患者均要求严格的饮食控制,并予基础降糖、降压等对症治疗,治疗组予补参消肾安汤加减水煎服,对照组予海昆肾喜胶囊口服。1个疗程为4周,治疗组与对照组均治疗2个疗程。结果:补参消肾安汤治疗消渴肾病脾肾阳虚兼瘀毒证患者30例,总有效率为80.0%,对照组的总有效率为63.3%,经过统计学处理,P0.05,具有显著性差异,治疗组在改善临床症状、降低血糖、降低尿蛋白等方面明显优于对照组。结论:补参消肾安汤能改善消渴肾病脾肾阳虚兼瘀毒证患者的临床症状及糖代谢均取得比较满意的疗效,疗效明显优于对照组,作为纯中药制剂,无明显的不良反应及副作用。通过临床观察验证了消渴肾病的病因病机毒损肾络、邪伏膜原的理论观点和通络导邪的重要性,值得进行深入研究和应用。
[Abstract]:Objective: to select the patients with deficiency of spleen and kidney yang as well as blood stasis toxin syndrome in order to evaluate the clinical efficacy and safety through systematic clinical observation and study, and to evaluate the clinical efficacy and safety of the patients by using the traditional Chinese medicine decoction, which is a self-made prescription commonly used by the tutor, for the purpose of objectively evaluating its clinical efficacy and safety.To provide a new way of thinking and treatment for Xiaoke Nephropathy.Methods: 60 cases of outpatients in Nanzheng Studio and Endocrine treatment area of Changchun University of traditional Chinese Medicine were randomly divided into treatment group and control group with 30 cases in each group.All patients were required to have strict dietary control and were treated with symptomatic treatment such as basic hypoglycemia, hypotension, etc. The treatment group was treated with Bushen Xiaoan decoction, and the control group was treated with Kunshenhei capsule. The course of treatment was 4 weeks.Both the treatment group and the control group were treated for 2 courses.Results: the total effective rate of Bushen Xiaoshenan decoction in treating 30 patients with deficiency of spleen and kidney yang and blood stasis toxin syndrome in Xiaoke nephropathy was 80.0.The total effective rate of control group was 63.30.There was significant difference after statistical treatment (P0.05). The treatment group was improving clinical symptoms and lowering blood sugar.The decrease of urine protein was better than that of the control group.Conclusion: Bushenxiaoshenan decoction can improve the clinical symptoms and glucose metabolism of patients with deficiency of spleen and kidney yang and blood stasis in patients with Xiaoke nephropathy, and the curative effect is obviously superior to that of the control group. As a pure Chinese medicine preparation, there are no obvious adverse reactions and side effects.Through clinical observation, it was proved that the etiology and pathogenesis of Xiaoke nephropathy could damage the kidney collaterals and collaterals, and the importance of clearing collaterals and guiding pathogenic factors should be further studied and applied.
【学位授予单位】：长春中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R255.4

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温肾解毒通络导邪法治疗消渴肾病（脾肾阳虚兼瘀毒证）的临床研究