降浊活血方治疗痰瘀互结型高脂血症的临床研究

发布时间：2018-04-18 00:17

本文选题：降浊活血方 + 高脂血症　；参考：《安徽中医药大学》2016年硕士论文

【摘要】：目的:本研究以病证结合,拟用健脾化痰,除湿祛瘀之法,观察降浊活血方对高脂血症痰瘀互结型患者的治疗效果及安全性。方法:将中医辨证属痰瘀互结型且西医确诊为高脂血症的80例患者,按其就诊先后顺序编为1到80号,通过随机分组的原则将80例患者分成治疗组(降浊活血方颗粒剂组)48例,对照组(中成药血脂康胶囊组)32例,治疗组给予降浊活血方(由单味颗粒剂组成,每日1贴,早晚餐后开水冲服),对照组给予血脂康胶囊(早晚餐后服用,每次2粒),疗程均为4周。结果:(1)疗效性评价:(1)两组患者治疗前后血脂指标的比较:同组治疗前后比较,差异有统计学意义(P0.01)。两组治疗后比较,治疗组在降低TG水平上优于对照组(P0.05);两组在降低TC、LDL-C水平,差异无统计学意义(P0.05);在升高HDL-C水平,差异无统计学意义(P0.05)。(2)两组病例治疗前后血脂指标疗效的比较:治疗组总有效率为83.33%,对照组总有效率为81.25%,差异无统计学意义(P0.05),两组疗效相当。(3)治疗前后两组患者SOD的比较:两组均可提高SOD水平,差异无统计学意义(P0.05)。(4)治疗前后两组患者CRP的比较:两组均可降低CRP水平,差异无统计学意义(P0.05)。(5)治疗前后两组中医临床证候疗效的比较:治疗组总有效率为87.5%,对照组总有效率为78.3%,两组疗效比较,差异有统计学意义(P0.05);两组均能改善中医证候积分,但治疗组优于对照组,差异有统计学意义(P0.05);在改善中医单项症状上降浊活血方组明显优于血脂康胶囊组,特别在胸闷、肢体沉重、便溏、食少等方面,疗效比较明显(P0.01),说明降浊活血方在改善中医临床症状方面疗效优于血脂康胶囊。(2)安全性评价:治疗组48例观察者用药前后检查的血、尿、大便常规,CK、CK-MB、ALT、AST、BUN、Scr、UA实验室检验结果均在正常医学参考值范围内,治疗前后心电图均正常,未见明显改变。说明降浊活血方在临床上使用较为安全,未发现不良反应、副作用。结论:降浊活血方能降低高脂血症患者血清中TG、TC、LDL-C、CRP水平,提高HDL-C、SOD水平,且改善患者临床症状,达到抗炎、抗氧化,改善血管内皮功能,预防动脉粥样硬化的作用。临床应用安全可靠,值的推广。
[Abstract]:Objective: to observe the efficacy and safety of Jiangzhuoxue prescription in treating hyperlipidemia patients with phlegm and blood stasis by combining disease with syndrome and using the method of invigorating spleen and resolving phlegm and removing dampness and removing blood stasis.Methods: 80 cases of hyperlipidemia diagnosed by western medicine were divided into treatment group (48 cases) according to the principle of random grouping.The control group (32 cases) treated with Xuezhikang capsule, the treatment group was given Jiangzhuo Huoxue recipe (composed of single granule, 1 paste per day, boiled water in the morning and evening), the control group was given Xuezhikang capsule (after morning and evening meal), the control group was treated with Xuezhikang capsule (morning and evening after meal).The course of treatment was 4 weeks.Results the comparison of blood lipid index before and after treatment in two groups: there was significant difference between the two groups before and after treatment (P 0.01).After treatment, the treatment group was better than the control group in reducing TG level, while the two groups had no significant difference in decreasing the level of TCU LDL-C, and increased the level of HDL-C.There was no significant difference between the two groups before and after treatment: the total effective rate of the treatment group was 83.33, and the total effective rate of the control group was 81.25. There was no significant difference between the two groups (P 0.05, P 0.05). The curative effect of the two groups was similar to that of the two groups before and after treatment, and the total effective rate of the treatment group was 83.33. The total effective rate of the control group was 81.25%.SOD levels were increased in both groups.There was no significant difference in CRP between the two groups before and after treatment. The CRP level was decreased in both groups.There was no significant difference between the two groups before and after treatment: the total effective rate of the treatment group was 87.5, the total effective rate of the control group was 78.3%, the difference between the two groups was statistically significant.But the treatment group was superior to the control group, the difference was statistically significant (P 0.05); in improving the single symptom of traditional Chinese medicine, the group of reducing turbidity and activating blood circulation was obviously superior to the group of Xuezhikang capsule, especially in the aspects of chest tightness, heavy limbs, loose stools and little food, etc.The curative effect was more obvious than that of P0.01, indicating that the curative effect of Jiangzhuoxue recipe in improving the clinical symptoms of traditional Chinese medicine was better than Xuezhikang capsule. (2) Safety evaluation: the blood and urine of 48 observers in the treatment group were examined before and after medication.The laboratory results of routine stool routine CKK-MBT test were all within the range of normal medical reference value, the electrocardiogram was normal before and after treatment, and no obvious change was found.It indicated that Jiangzhuo Huoxue prescription was safe in clinical use, no side effects and side effects were found.Conclusion: Jiangzhuo Huoxue prescription can reduce the level of serum TGN TCU LDL-CU CRP, improve the level of HDL-CU SOD, improve the clinical symptoms, achieve anti-inflammatory, anti-oxidation, improve vascular endothelial function and prevent atherosclerosis in patients with hyperlipidemia.The clinical application is safe and reliable, the promotion of value.
【学位授予单位】：安徽中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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