桃红四物汤加减联合NB-UVB治疗银屑病气滞血瘀证的临床疗效及对IL-4、IL-22的研究

发布时间：2018-04-19 13:51

本文选题：银屑病 + 气滞血瘀　；参考：《山东中医药大学》2016年硕士论文

【摘要】：目的:观察桃红四物汤加减联合窄谱中波紫外线(NB-UVB)治疗寻常型银屑病气滞血瘀证的临床疗效,以及治疗前后患者血清IL-4及IL-22水平的变化,初步探讨桃红四物汤治疗气滞血瘀型银屑病的作用机理。方法:将气滞血瘀型银屑病患者63例随机分为治疗组32例和对照组31例。治疗组:桃红四物汤加减内服联合NB-UVB照射,外用达力士软膏。对照组:消银胶囊内服配合达力士软膏外用。治疗前后应用ELISA法检测血清中IL-4及IL-22两种细胞因子的水平。结果:治疗组痊愈率53.13%,总有效率为96.88%;对照组痊愈率为25.81%,总有效率为80.65%。治疗组的治愈率明显高于对照组(P0.05),治疗组的总有效率也高于对照组,但没有统计学意义(P0.05)。此外两组患者起效疗程比较也有显著性差异(P0.05),显示治疗组疗效好且起效快。治疗组患者治疗前后血清中IL-4、IL-22水平检测,结果示:治疗组患者治疗前IL-4、IL-22水平较正常值明显升高,治疗后IL-4、IL-22指标均较治疗前降低(P0.05)。结论:桃红四物汤加减内服联合NB-UVB照射,外用达力士软膏治疗气滞血瘀型银屑病较对照组治愈率高,起效快,疗效肯定,并可显著调控患者体内IL-4及IL-22的水平,值得推广。
[Abstract]:Objective: to observe the clinical effect of Taohong Siwu decoction combined with NB-UVB in the treatment of qi stagnation and blood stasis syndrome of psoriasis vulgaris, and the changes of serum IL-4 and IL-22 levels before and after treatment.To explore the mechanism of Taohong Siwu decoction in treating psoriasis of qi stagnation and blood stasis type.Methods: 63 cases of psoriasis with qi stagnation and blood stasis were randomly divided into treatment group (n = 32) and control group (n = 31).Treatment group: Taohong Siwu decoction plus or minus combined with NB-UVB irradiation, external use of Dalius ointment.Control group: Xiaoyin capsule combined with Dalius ointment for external use.Serum levels of IL-4 and IL-22 were measured by ELISA before and after treatment.Results: the cure rate of the treatment group was 53.13 and the total effective rate was 96.888.The cure rate of the control group was 25.81 and the total effective rate was 80.65.The cure rate of the treatment group was significantly higher than that of the control group (P 0.05), and the total effective rate of the treatment group was also higher than that of the control group, but there was no significant difference between the treatment group and the control group (P 0.05).In addition, there was a significant difference between the two groups in the effective course of treatment, which showed that the treatment group had good curative effect and rapid onset.The levels of IL-4 and IL-22 in serum of the patients in the treatment group before and after treatment were detected. The results showed that the levels of IL-4 and IL-22 in the treatment group were significantly higher than those in the normal value before and after treatment, and the indexes of IL-4 and IL-22 in the treatment group were lower than those in the control group before and after treatment (P 0.05).Conclusion: Taohong Siwu decoction plus or minus internal administration combined with NB-UVB irradiation and external application of Dalius ointment in the treatment of psoriasis of qi stagnation and blood stasis type has a higher cure rate, faster onset and better curative effect, and can significantly regulate the levels of IL-4 and IL-22 in patients, which is worth popularizing.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R275.9

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