桃红白癜方治疗气滞血瘀型白癜风的临床疗效观察

发布时间：2018-04-23 02:35

本文选题：白癜风 + 桃红白癜方　；参考：《湖北中医药大学》2017年硕士论文

【摘要】：目的:观察桃红白癜方治疗气滞血瘀型白癜风的临床疗效及安全性,充分发挥中医中药治疗白癜风的特色优势,为临床提供更加安全有效的治疗途径。方法:本次入选患者均来自于2015年5月-2016年5月湖北省中医院皮肤科门诊,在所有与白癜风诊断和排除标准相符的患者中选择气滞血瘀型作为本次研究对象,共观察120个病例,采用随机对照原则分为三组:治疗组、对照组A、对照组B,每组40例。治疗组采用内服中药桃红白癜方水煎剂每日一剂,2次/日,200ml/次,基本药物组成为:赤芍15g,丹皮20g,桃仁10g,红花15g,柴胡10g,白芷15g,蝉蜕10g,蒲黄15g,补骨脂10g,丹参20g,当归15g,紫河车5g,五灵脂15g,浮萍10g,鸡血藤30g,同时联合外擦卤米松乳膏,2次/日,连用2周后停用一周,皮损处紫外线照射隔日1次。对照组A采用胸腺肽肠溶片口服,3次/日,2粒/次,同时联合外擦卤米松乳膏和皮损处紫外线照射(方法同前)。对照组B采用薄芝片口服,3次/日,2粒/次,卤米松乳膏外擦和皮损处紫外线照射治疗(方法同前)。4周为一疗程,共观察4个疗程,根据治疗前后皮损变化及复查血、尿、大便常规、肝肾功能情况,如实评价桃红白癜方的临床疗效和安全性。结果:1.试验共收集120例患者,完成111例,终止9例。2.治疗1个疗程后,治疗组与对照组A、B对比疗效均有统计学差异,P0.05。对照组A与B对比疗效无统计学差异,P0.05;三组总有效率分别为51.4%、30.6%、26.3%。3.治疗2个疗程后,治疗组与对照组A、B对比疗效均有统计学差异,P0.05。对照组A与B对比疗效有统计学差异,P0.05;三组总有效率分别为70.3%、50.0%、28.9%。4.治疗3个疗程后,治疗组、对照组A对比对照组B疗效均有统计学差异,P0.05。治疗组与对照组A对比疗效无统计学差异,P0.05;三组总有效率分别为73.0%、61.1%、42.1%。5.治疗4个疗程后,治疗组、对照组A对比对照组B疗效均有统计学差异,P0.05。治疗组与对照组A对比疗效无统计学差异,P0.05;三组总有效率分别为78.4%、69.4%、47.4%。结论:1.内服桃红白癜方联合卤米松乳膏和紫外线照射、口服胸腺肽肠溶片联合卤米松乳膏和紫外线照射及口服薄芝片联合卤米松乳膏和紫外线照射对气滞血瘀型白癜风均有疗效;2.内服桃红白癜方联合卤米松乳膏和紫外线照射相比于口服胸腺肽肠溶片联合卤米松乳膏和紫外线照射,在治疗初期能较快控制病情,避免病情进一步发展。3.内服桃红白癜方联合卤米松乳膏和紫外线照射治疗气滞血瘀型白癜风,无论在近期还是远期疗效上,均优于口服薄芝片联合卤米松乳膏和紫外线照射。4.内服桃红白癜方对气滞血瘀型白癜风治疗有效,能够早期改善并稳定患者病情,且患者血、尿、大便常规、肝肾功能指标均在正常范围,临床安全性好,值得进一步推广使用。
[Abstract]:Objective: to observe the clinical efficacy and safety of Taohong white purpura in the treatment of vitiligo with qi stagnation and blood stasis, to give full play to the unique advantages of traditional Chinese medicine in the treatment of vitiligo, and to provide a more safe and effective way for clinical treatment. Methods: all the patients were selected from the dermatology clinic of Hubei traditional Chinese Medicine Hospital from May 2015 to May 2016. The patients with Qi stagnation and Blood stasis were selected from all patients who were in accordance with the criteria of diagnosis and exclusion of vitiligo, and 120 cases were observed. Three groups were randomly divided into three groups: treatment group, control group A and control group B, with 40 cases in each group. The treatment group was treated with Chinese medicine Taohong white purpura decoction once a day twice a day and 200 ml / time. The essential drugs are: Radix Paeoniae Alba 15g, paeonia 20g, peach kernel 10g, safflower 15g, Bupleurum 10g, dahurica 15g, cicada slough 10g, fuhuang 15g, psoralen 10g, salvia miltiorrhiza 20g, angelica sinensis 15g, Ziheche 5g, Wulingfat 15g, duckweed 10g, chicken blood rattan 30g, at the same time combined with external brine and rice pine cream twice a day, After 2 weeks of continuous use, the skin was stopped for one week, and the lesions were irradiated by ultraviolet rays once every other day. Control group A was treated with Thymosin enteric-coated tablets 3 times a day and 2 tablets per day combined with external brine mizone cream and ultraviolet radiation at skin lesions. The control group B was treated by oral administration of Boshiba tablets three times a day, two tablets per day, and brine mizone cream and ultraviolet radiation at the lesion. (methods: the same course was given at 4 weeks before and after treatment, and 4 courses of treatment were observed. According to the changes of skin lesions before and after treatment and the reexamination of blood and urine, there was no significant difference between the two groups. Routine defecation, liver and kidney function, truthfully evaluate the clinical efficacy and safety of peach-red purpura. The result is 1: 1. A total of 120 patients were collected, 111 completed and 9 terminated. 2. 2. After one course of treatment, there was significant difference in the therapeutic effect between the treatment group and the control group (P 0.05). There was no significant difference in the curative effect between control group A and group B (P 0.05), and the total effective rate of three groups was 51.4 and 30.6 and 26.3respectively. After two courses of treatment, there was a significant difference in the therapeutic effect between the treatment group and the control group (P 0.05). The control group A and B contrast curative effect has the statistical difference (P0.05), the three groups total effective rate is respectively 70.3% 50.050.050.028. 9. 4. After 3 courses of treatment, the curative effect of treatment group and control group A was significantly different from that of control group B (P 0.05). There was no statistical difference between the treatment group and the control group (P 0.05), the total effective rates of the three groups were 73.0 and 61.1 respectively. After 4 courses of treatment, the curative effect of treatment group and control group A was significantly different from that of control group B (P 0.05). There was no significant difference in the curative effect between the treatment group and the control group (P 0.05). The total effective rate of the three groups was 78.4% and 69.4% respectively. Conclusion 1. Oral administration of Taohong white purpura prescription combined with halomethasone cream and ultraviolet radiation, oral thymosin enteric-coated tablets combined with halomethasone cream and ultraviolet radiation and oral Boshiba tablets combined with halogen milisone cream and ultraviolet radiation had curative effects on vitiligo of Qi stagnation and Blood stasis type. Compared with oral thymosin enteric-coated tablets combined with halomethasone cream and ultraviolet radiation, oral administration of Taohong purpura decoction combined with halomethasone cream and ultraviolet radiation could control the disease quickly and avoid further development of the disease at the early stage of treatment. The treatment of vitiligo of qi stagnation and blood stasis type by internal administration of Taohong white purpura prescription combined with halomethasone cream and ultraviolet radiation was superior to oral Boshiba tablet combined with halomethasone cream and ultraviolet irradiation. It is effective to treat vitiligo with Qi stagnation and blood stasis, and can improve and stabilize the patient's condition early, and the patients' blood, urine, stool routine, liver and kidney function index are in normal range, clinical safety is good, it is worth further popularizing.
【学位授予单位】：湖北中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R275.9

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