杞菊地黄丸对白内障术后干眼症患者疗效,BUT,SIT及FL的影响

发布时间：2018-04-23 15:51

本文选题：杞菊地黄丸 + 白内障手术　；参考：《中国实验方剂学杂志》2017年23期

【摘要】：目的:探讨杞菊地黄丸对白内障术后干眼症患者疗效、泪膜破裂时间(tear breakup time,BUT),基础泪液分泌实验(schirmer I test,SIT)及角膜荧光素染色(fluorescent test,FL)的影响。方法:研究对象选自2016年2月—2017年1月华中科技大学同济医学院附属武汉中心医院收治的116例白内障术后干眼症患者,采取随机数字表将其分成两组,其中观察组58例(64眼),对照组58例(66眼)。两组患者均采用人工泪液治疗,观察组联合给予杞菊地黄丸治疗,比较两组临床疗效及治疗前后BUT,SIT,FL评分及症状评分变化情况。结果:观察组治疗总有效率为93.75%,相对于对照组的77.27%显著上升(P0.01)。两组治疗后2周,1个月,3个月BUT均较治疗前显著延长(P0.01),观察组治疗后各时点延长更明显(P0.05)。两组治疗后2周,1个月,3个月SIT均较治疗前显著增加(P0.01),观察组治疗后各时点增加幅度更明显(P0.05)。两组治疗后2周,1个月,3个月FL评分均较治疗前显著降低(P0.01),观察组治疗后各时点下降更显著(P0.01)。两组治疗后2周,1个月,3个月干眼症状评分均较治疗前显著下降(P0.01),观察组治疗后各时点下降更显著(P0.01)。结论:杞菊地黄丸治疗白内障术后干眼症可有效提高泪膜稳定性,改善视觉功能,疗效确切。
[Abstract]:Objective: to investigate the effects of Qiju Dihuang pills on dry eye after cataract surgery, tear film rupture time (tear breakup time but), basic tear secretion experiment (Schimer I test site) and corneal fluorescein staining (fluoresent test FLL). Methods: from February 2016 to January 2017, 116 patients with xerophthalmia treated in Wuhan Central Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology were randomly divided into two groups. The observation group (58 cases, 64 eyes) and the control group (58 cases, 66 eyes). Patients in both groups were treated with artificial tear, and the observation group were treated with Qiju Dihuang pills. The clinical efficacy and the changes of butathium-SITFL score and symptom score before and after treatment were compared between the two groups. Results: the total effective rate of the observation group was 93.75%, which was significantly higher than that of the control group (77.27%). BUT was significantly prolonged at 2 weeks, 1 month and 3 months after treatment in both groups compared with that before treatment. In the observation group, the prolongation of P0.05 was more obvious at each time point after treatment. The SIT of the two groups increased significantly 2 weeks, 1 month and 3 months after treatment compared with that before treatment. In the observation group, the increase was more significant at each time point after treatment than that before treatment (P 0.05). After 2 weeks, 1 month and 3 months after treatment, FL scores in both groups were significantly lower than those before treatment. After 2 weeks, 1 month and 3 months of treatment, the scores of dry eye symptoms in both groups were significantly lower than those before treatment (P 0.01). Conclusion: Qiju Dihuang pills can effectively improve the stability of tear film and visual function after cataract surgery.
【作者单位】：华中科技大学同济医学院附属武汉中心医院;
【基金】：湖北省教育厅科研指导性项目(B2016115)
【分类号】：R276.7

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