益气通阳活血方治疗糖尿病下肢血管病变的临床观察

发布时间：2018-04-24 03:26

本文选题：益气通阳活血方 + 气虚寒凝血瘀　；参考：《山东中医药大学》2016年硕士论文

【摘要】：目的:通过观察益气通阳活血方治疗气虚寒凝血瘀型糖尿病下肢血管病变(lower extremity arterial disease in diabetes patients,LEADDP)的临床疗效,探讨益气通阳、活血化瘀法的作用机制,拓展治疗糖尿病下肢血管病变的思路。方法:研究选取LEADDP患者60例,随机分为两组,观察组和对照组各30例。在两组均给予糖尿病基础治疗、阿司匹林和辛伐他汀口服的前提下,观察组加用益气通阳活血方加减,疗程均为8周,后进行疗效性评定。观察治疗前后证候积分、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、纤维蛋白原(FIB)和踝肱指数(ABI)的变化,对相关数据采用统计软件进行统计分析,评价其综合疗效。结果:1中医证候疗效比较:经过8周治疗,两组患者证候积分明显改善,观察组总有效率为86.67%,对照组总有效率为70%。两组患者治疗后中医证候组间比较P0.05,有统计学差异。治疗后两组患者的单个症状疗效比较,肢体麻木、疼痛等症状的改善观察组均优于对照组,且有统计学意义。2实验室指标比较:两组患者治疗前后总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白、纤维蛋白原和踝肱指数均明显改善,与本组治疗前比较,P0.05,且观察组与对照组比较,P0.05,观察组明显优于对照组。3安全性分析:治疗期间,两组患者均未出现不良反应和毒副作用,安全性较好。结论:益气通阳活血方可显著降低糖尿病下肢血管病变患者的证候积分,能有效改善患者总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白、纤维蛋白原和踝肱指数的水平,疗效确切,且用药期间无毒副作用。证明益气通阳活血方对于临床治疗气虚寒凝血瘀型糖尿病下肢血管病变具有较好的疗效。同时,也说明从气虚寒凝血瘀立论是治疗糖尿病下肢血管病变的重要研究思路。
[Abstract]:Objective: to observe the clinical effect of Yiqi Tongyang Huoxue recipe in treating lower extremity extremity arterial disease in diabetes patients with diabetes mellitus with Qi deficiency, cold coagulation and blood stasis, and to explore the mechanism of invigorating qi and removing yang and activating blood circulation and removing blood stasis. To expand the treatment of diabetic lower extremity vascular disease. Methods: 60 patients with LEADDP were randomly divided into two groups: the observation group (n = 30) and the control group (n = 30). On the premise of taking aspirin and simvastatin orally, the two groups were given basic treatment of diabetes mellitus. The observation group was treated with Yiqi Tongyang Huoxue recipe for 8 weeks, and the curative effect was evaluated. The changes of syndromes score, TC, TG, LDL-CU, HDL-CU, FIBF and ABI were observed before and after treatment. Statistical software was used to analyze the related data and evaluate the comprehensive curative effect. Results: after 8 weeks of treatment, the syndromes integral of the two groups were obviously improved. The total effective rate of the observation group was 86.67 and the total effective rate of the control group was 70. Two groups of patients after treatment compared with traditional Chinese medicine syndrome group P0.05, there was statistical difference. Two groups of patients after treatment of single symptoms, limb numbness, pain and other symptoms of the observation group were better than the control group, and there was statistical significance .2 laboratory index comparison: the two groups of patients before and after treatment total cholesterol, triglyceride, Low density lipoprotein, high density lipoprotein, fibrinogen and ankle brachial index were all significantly improved, compared with those before treatment (P 0.05), and the observation group compared with control group (P 0.05). The observation group was superior to the control group in safety analysis. There were no adverse reactions and side effects in both groups, and the safety was good. Conclusion: Yiqi Tongyang Huoxue decoction can significantly reduce the syndrome score of patients with diabetic lower extremity vascular disease, and can effectively improve the levels of total cholesterol, triglyceride, low density lipoprotein, high density lipoprotein, fibrinogen and ankle brachial index. The curative effect is definite and there is no side effect during medication. It is proved that Yiqi Tongyang Huoxue prescription has good curative effect on lower extremity vascular disease of diabetes mellitus with deficiency of qi and cold coagulation and blood stasis. At the same time, it also shows that the theory of qi deficiency, cold coagulation and blood stasis is an important research idea in the treatment of diabetic lower extremity vascular disease.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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