益肾化湿颗粒辅助治疗慢性肾炎的Meta分析

发布时间：2018-04-25 18:55

本文选题：益肾化湿颗粒 + 慢性肾炎　；参考：《中国药房》2017年15期

【摘要】：目的:系统评价益肾化湿颗粒辅助治疗慢性肾炎的疗效,为临床提供循证参考。方法:计算机检索中国生物医学文献数据库(CBM)、相关期刊论文(CJFD)、万方数据库、中文科技期刊数据库(VIP)、Medline、Pub Med、EMBase、Cochrane图书馆,收集益肾化湿颗粒辅助治疗慢性肾炎的随机对照试验(RCT),并手工检索相关中文期刊。由两位研究者独立进行筛选和资料提取后,按照改良的Jadad评分量表对纳入文献质量进行评价,采用Rev Man 5.3.5统计软件进行Meta分析。结果:共纳入8项RCT,合计1 028例患者。Meta分析结果显示,试验组患者总有效率[RR=1.33,95%CI(1.24,1.42),P0.001]显著高于对照组,24h尿蛋白定量[MD=-0.32,95%CI(-0.40,-0.24),P0.001]、血肌酐[MD=-22.38,95%CI(-23.37,-21.39),P0.001]、血尿素氮[MD=-1.45,95%CI(-2.05,-0.84),P0.001]均显著低于对照组,差异均有统计学意义。结论:在西医常规治疗基础上,加用益肾化湿颗粒辅助治疗慢性肾炎疗效较好,可以降低患者24 h尿蛋白定量,改善肾功能。
[Abstract]:Objective: to evaluate the efficacy of Yishen Huashi granule in the treatment of chronic glomerulonephritis. Methods: the Chinese Biomedical Literature Database (CBM), the Chinese Journal full text Database (CJFDN), the Wanfang Database and the Chinese Sci-tech Journal Database were searched by computer. A randomized controlled trial of Yishen Huashi granule for the treatment of chronic glomerulonephritis was collected and the relevant Chinese journals were searched manually. After independent screening and data extraction by two researchers, the quality of the literature was evaluated according to the modified Jadad scoring scale, and the Meta analysis was carried out with Rev Man 5.3.5 statistical software. Results: a total of 1 028 patients. Meta-analysis showed that the total effective rate of patients in the trial group was significantly higher than that in the control group. The total effective rate [RRN 1.33J 95CIN 1.241.42] was significantly higher than that in the control group [MD-0.32CI-95 CI-0.40-0.24P0.001], serum creatinine [MD-22.38995 CI -23.37- 21.39P0.001], blood urea nitrogen (MD-1.4595CI-2.05CI-0.84P0.001) were significantly lower than those in the control group (P 0.001). Conclusion: on the basis of routine treatment of western medicine, the treatment of chronic nephritis with Yishen Huashi granule is effective, which can reduce the quantity of urinary protein in 24 hours and improve renal function.
【作者单位】：海南省中医院;
【分类号】：R277.5

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