宫颈炎方治疗湿热下注型宫颈糜烂的临床观察及其对IL-6、TNF-α及hs-CRP影响的研究

发布时间：2018-04-26 14:00

本文选题：宫颈糜烂 + 湿热下注型　；参考：《安徽中医药大学》2016年硕士论文

【摘要】：目的:观察宫颈炎方联合保妇康栓治疗湿热下注型宫颈糜烂患者的临床疗效,及其对宫颈糜烂患者血清hs-CRP、IL-6及TNF-α水平的影响,探讨宫颈炎方联合保妇康栓防治宫颈糜烂的可能作用机制,为中医药防治宫颈糜烂提供临床参考和实验室依据。方法:门诊最终收集符合研究条件的宫颈糜烂患者80例,将其随机分为实验组和对照组,其中实验组40例,于月经干净后3天开始内服宫颈炎方,并联合保妇康栓外用治疗;对照组40例,仅予以保妇康栓外用治疗。两组疗程均为3个月经周期,观察治疗前、治疗后两组患者的临床症状、体征,及其宫颈糜烂患者血清hs-CRP、IL-6及TNF-α的数值变化。结果:1、两组治疗后临床疗效比较:治疗3个月经周期后,两组综合疗效比较:实验组总有效率为92.5%,对照组总有效率为82.5%,两组综合疗效有显著差异(P0.05);治疗3个月经周期后,中医证候疗效比较实验组总有效率为95.0%,对照组总有效率为85.0%,两组中医证候疗效有极显著差异(P0.01);治疗后两组患者中医主证之带下量的疗效比较:实验组与对照组的总有效率分别为100%和95.0%,两组比较有极显著差异(P0.01);治疗后两组患者中医主证之带下颜色的疗效比较:实验组与对照组的总有效率分别为95.0%、85.0%,两组有极显著差异(P0.01)。2、两组治疗前后中医证候积分比较:治疗3个月经周期后,实验组治疗前、后积分比较有极显著差异(P0.01);对照组治疗前、后积分比较有显著差异(P0.05),实验组治疗前、后与对照组治疗前、后,证候积分均可见显著下降,但治疗后两组患者积分比较有显著差异(P0.05),因此,在中医证候积分的下降方面,实验组明显优于对照组。3、两组患者治疗前后血清hs-CRP、IL-6及TNF-α水平的比较:治疗3个月经周期后,两组患者血清hs-CRP、IL-6及TNF-α水平均较治疗前有所下降,实验组治疗前、后比较与对照组治疗前、后比较均有极显著差异。治疗后两组患者血清hs-CRP及TNF-α水平比较均有显著差异(P0.05),IL-6水平比较有极显著差异(P0.01),两组患者治疗后在血清hs-CRP、IL-6及TNF-α水平下降方面,实验组明显优于对照组。结论:宫颈炎方联合保妇康栓治疗湿热下注型宫颈糜烂取得了较好的临床疗效;该法能够很好的改善宫颈糜烂患者湿热下注证的临床症状、体征;并且能够降低宫颈糜烂患者血清hs-CRP、IL-6及TNF-α炎性因子的水平。研究显示宫颈炎方联合保妇康栓治疗湿热下注型宫颈糜烂是一种行之有效的方法,其作用机理可能是通过抗炎及其调节机体免疫功能而发挥临床疗效。
[Abstract]:Objective: to observe the clinical effect of the combination of Weiyan Fang and Baofukang suppository in the treatment of cervical erosion with dampness and heat, and to observe the effect on the serum levels of hs-CRPN6 and TNF- 伪 in patients with cervical erosion. To explore the possible mechanism of prevention and treatment of cervical erosion by combination of Weiyan Fang and Baofukang suppository, and to provide clinical reference and laboratory basis for the prevention and treatment of cervical erosion by traditional Chinese medicine. Methods: 80 patients with cervical erosion were randomly divided into experimental group (n = 40) and control group (n = 40). 40 cases in the control group were treated with Baofukang suppository for external use only. The clinical symptoms and signs of the two groups were observed before and after treatment, and the changes of serum hs-CRPU IL-6 and TNF- 伪 in patients with cervical erosion were observed. Results: after 3 menstrual cycles, the total effective rate of the experimental group was 92.5 and the total effective rate of the control group was 82.5. There was a significant difference between the two groups in the comprehensive curative effect (P 0.05), and after 3 menstrual cycles, the total effective rate of the experimental group was 92.5 and that of the control group was 82.5. The total effective rate of the experimental group is 95.0 and the total effective rate of the control group is 85.0. There is a very significant difference in the curative effect of TCM syndrome between the two groups. The total effective rate was 100% and 95.0%, respectively, and there was a significant difference between the two groups (P 0.01). After treatment, the total effective rates of the two groups were 95.010% and 85.0%, respectively. There was a significant difference between the two groups. Comparison of TCM syndromes before and after treatment: after 3 menstrual cycles, Before and after treatment, there was a significant difference between the experimental group and the control group (P 0.01) and the control group (P 0.05). Before, after and after treatment, the syndromes scores of the experimental group were significantly decreased, and that of the control group was significantly lower than that of the control group before and after treatment. But there was significant difference between the two groups after treatment. Therefore, the experimental group was superior to the control group in decreasing the score of TCM syndromes. The comparison of serum hs-CRPIL-6 and TNF- 伪 levels before and after treatment in the two groups: after 3 menstrual cycles, The serum levels of hs-CRPU IL-6 and TNF- 伪 in the two groups were lower than those before treatment, and there were significant differences between the experimental group and the control group before and after treatment. There were significant differences in serum hs-CRP and TNF- 伪 levels between the two groups after treatment. After treatment, the serum levels of hs-CRPnIL-6 and TNF- 伪 in the two groups were significantly higher than those in the control group. Conclusion: the combination of Weiyan recipe and Baofukang suppository in treating cervical erosion with dampness and heat has obtained better clinical curative effect, which can improve the clinical symptoms and signs of damp-heat betting syndrome in patients with cervical erosion. It can also reduce the serum levels of hs-CRPU IL-6 and TNF- 伪 inflammatory factors in patients with cervical erosion. The research shows that the combination of Weiyan Fang and Baofukang suppository is an effective method for treating cervical erosion with dampness and heat, and its mechanism may be to exert the clinical curative effect by anti-inflammation and regulating the immune function of the body.
【学位授予单位】：安徽中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R271.9

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