内外合治脾肾阳虚型慢性原发性肾小球肾炎回顾性分析

发布时间：2018-04-27 00:08

本文选题：益火煎 + 中药足浴　；参考：《辽宁中医药大学》2017年硕士论文

【摘要】：目的:采用回顾性研究的方法,观察80例益火煎配合中药足浴干预脾肾阳虚型慢性原发性肾小球肾炎(Chronic primary glomerulonephritis CPGN)的临床疗效,为内外合治提供临床依据。资料与方法:搜集2015年5月-2016年11月就诊于辽宁中医药大学附属医院肾内科脾肾阳虚型CPGN 80例,随机分为对照组(40例)和治疗组(40例)。对照组均是内科常规治疗,治疗组是在此基础上口服温补肾阳、健脾利湿之“益火煎”配合“腰痛方”中药足浴。观察两组病例治疗前后中医症状的改善情况,以及尿蛋白(Protein Pro)、镜检红细胞(Red blood cell RBC)、24小时尿蛋白定量、血肌酐(Serum creatinin e Scr)、尿素氮(Blood urea nitrogen BUN)的变化情况。结果:1.综合疗效:治疗组总有效率是85%,对照组总有效率是67.5%,治疗组优于对照组(P0.05)。2.中医症候积分:治疗组总有效率是82.5%,对照组总有效率是72.5%,治疗组优于对照组(P0.05)。单项中医症状改善情况,食少纳呆两组无差异(P0.05),其余症状两组均有差异(P0.05),其中腰膝酸软、体倦乏力两组差异最明显(P0.01)。3.尿蛋白:两组尿蛋白定性均减少,治疗组优于对照组(P0.05)。4.尿镜检红细胞:两组镜检红细胞均减少,治疗组优于对照组(P0.01)。5.24小时尿蛋白定量:两组24小时尿蛋白定量均减少,治疗组优于对照组(P0.05)。6.血肌酐、尿素氮:两组Scr、BUN均降低,治疗组优于对照组(P0.05)。结论:益火煎配合中药足浴的内外合治法干预脾肾阳虚型慢性原发性肾小球肾炎,明显改善腰膝酸软、体倦乏力中医症状,减少蛋白尿、血尿及降低血肌酐、尿素氮。
[Abstract]:Objective: to observe the clinical curative effect of 80 cases of chronic primary glomerulonephritis with spleen and kidney yang deficiency treated by Yihuo decoction combined with traditional Chinese medicine foot bath in order to provide clinical basis for internal and external treatment. Materials and methods: from May 2015 to November 2016, 80 cases of CPGN with deficiency of spleen and kidney were randomly divided into control group (n = 40) and treatment group (n = 40). The control group was treated with routine internal medicine, and the treatment group was treated with "Yihuo decoction" combined with "low back pain prescription" on the basis of oral warming and reinforcing kidney yang, invigorating spleen and dampness. To observe the improvement of TCM symptoms before and after treatment, and the changes of urine protein proton, erythrocyte red blood cell RBC 24 hour urine protein, serum creatinine, serum creatinine creatinin e creatinine, urea nitrogen and blood urea nitrogen BUN) before and after treatment. The result is 1: 1. Comprehensive curative effect: the total effective rate of the treatment group is 85%, the total effective rate of the control group is 67.5%, the treatment group is superior to the control group (P 0.05). TCM symptom score: the total effective rate of the treatment group was 82.5 and the total effective rate of the control group was 72.5. The treatment group was superior to the control group (P 0.05). There was no difference between the two groups in improving the symptoms of single TCM, but there was no difference in the other two groups, among which the waist and knee were sore and soft, and the tiredness of body was the most obvious difference between the two groups. Urine protein: the qualitative quality of urine protein in both groups was decreased, and the treatment group was superior to the control group (P 0.05). 4. Urine microscopic examination red blood cells: both groups of microscopic red blood cells decreased, the treatment group than the control group P0.01. 5.24 hours urine protein quantitative: the two groups 24 hours urine protein quantitative reduction, the treatment group is better than the control group P0.05. 6. Serum creatinine and urea nitrogen: Scrn bun decreased in both groups, and the treatment group was superior to the control group (P 0.05). Conclusion: Yihuo decoction combined with internal and external treatment of traditional Chinese medicine foot bath can obviously improve the symptoms of chronic primary glomerulonephritis with deficiency of spleen and kidney yang, reduce proteinuria, blood urine and blood creatinine, urea nitrogen.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R277.5

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