资生防感颗粒治疗反复呼吸道感染脾肾两虚型临床观察

发布时间：2018-04-28 00:45

本文选题：反复呼吸道感染 + 脾肾两虚　；参考：《黑龙江中医药大学》2017年硕士论文

【摘要】：目的:观察资生防感颗粒治疗小儿反复呼吸道感染脾肾两虚型的临床疗效。方法:将最终符合入选标准的66例反复呼吸道感染患儿,随机分为治疗组和对照组各33例。其中治疗组口服资生防感颗粒,对照组口服复可托(脾氨肽口服冻干粉),在治疗开始前对2组患儿的监护人进行宣教,给予详尽有效的护理方案及病情指导。治疗8周后进行中医证候疗效、单项中医症状及免疫指标IgA、IgG、IgM的评定。治疗结束后随访1年评估疾病的临床疗效(包括呼吸道感染的次数、平均病程及病种)。结果:1.两组样本临床总疗效:治疗组总有效率为90.91%,对照组总有效率为81.82%,治疗组的总有效率优于对照组;在总疗效上治疗组与对照组比较(P0.05),两组比较差异具有统计学意义。2.中医证候疗效及中医单项症状分析:治疗组总有效率为90.91%;对照组总有效率为60.61%。治疗组疗效优于对照组,经检验(p0.01),两组间存在显著差异;在改善中医单项症状上,治疗组在改善食少、多汗、大便溏烂、乏力、夜尿多症状上疗效优于对照组,两组比较(P0.05),差异具有统计学意义。3.感染次数、平均病程及病种分析:两组患儿在治疗前后感染次数上比较(p0.01),表明治疗前后两组间存在显著性差异;两组患儿在治疗前后平均病程计分上比较(p0.01),两者比较有显著差异,治疗后两组患儿在缩短平均病程上计分比较(P0.05),表明两组在缩短平均病程上两者疗效相当;两组患儿在治疗前后病种计分上比较(P0.05),两组间无明显差异。4.血清IgA、IgG、IgM值分析:两组患儿在治疗后血清IgA、IgG、IgM值均较治疗前提高,经t检验(p0.05),两组比较差异具有统计学意义。结论:1.资生防感颗粒治疗小儿反复呼吸道感染(脾肾两虚型)有显著疗效可减少复感患儿发病次数,缩短平均病程。2.资生防感颗粒在改善中医证候疗效及单项中医症状(食少、多汗、大便溏烂、乏力、夜尿多)方面疗效优于对照组。3.资生防感颗粒可提高复感患儿血清IgA、IgG、IgM的水平。
[Abstract]:Objective: to observe the clinical effect of Zishenfanggan granule on spleen and kidney deficiency in children with recurrent respiratory tract infection. Methods: 66 children with recurrent respiratory tract infection were randomly divided into treatment group (n = 33) and control group (n = 33). The treatment group was treated with Zishenfanggan granule and the control group was treated with Fu Keto (spleen ammonia peptide). The guardians of the two groups were given education before the treatment, and the detailed and effective nursing program and the condition guidance were given. After 8 weeks of treatment, the curative effect of TCM syndromes, single TCM symptoms and immunological index IgGG IgM were evaluated. The clinical efficacy of the disease (including the number of respiratory infections, the average course of disease and the disease species) was evaluated 1 year after treatment. The result is 1: 1. The total effective rate of the treatment group was 90.91, the total effective rate of the control group was 81.82, the total effective rate of the treatment group was better than that of the control group, and the total effective rate of the treatment group was higher than that of the control group (P 0.05), the difference between the two groups was statistically significant. Analysis of TCM syndromes and single symptoms: the total effective rate of the treatment group was 90.91m; the total effective rate of the control group was 60.61. The curative effect of the treatment group was better than that of the control group, and there was a significant difference between the two groups in the improvement of the single symptom of traditional Chinese medicine, the therapeutic effect of the treatment group was better than that of the control group in improving the single symptom of traditional Chinese medicine, such as less food, more sweat, loose stool, fatigue, and more symptoms of nocturia. The difference between the two groups was statistically significant. Infection times, mean course of disease and disease type analysis: the infection times of the two groups were compared before and after treatment, indicating that there was a significant difference between the two groups before and after treatment. There was significant difference between the two groups in the score of mean course of disease before and after treatment, and there was a significant difference between the two groups. After the treatment, the score of the two groups in shortening the mean course of disease was higher than that of P0.05, which indicated that the two groups had the same curative effect in shortening the mean course of disease. There was no significant difference between the two groups in the score of disease type before and after treatment. Analysis of serum IgA IgM: after the treatment, the serum IgA + IgG + IgM levels of the two groups were higher than those before treatment, and the difference between the two groups was statistically significant by t test (p 0. 05). Conclusion 1. Zishengfanggan granule has significant curative effect on recurrent respiratory tract infection (deficiency of spleen and kidney) in children. It can reduce the incidence times and shorten the average course of disease by 0.2. Zishenfanggan granule is superior to the control group in improving the curative effect of TCM syndrome and single TCM symptom (less food, more sweat, loose stool, fatigue, nocturnal urine). Zishengfanggan granule can improve the level of IgA- IgG _ (+) IgM in serum of children with resuscitation.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R272

【相似文献】