清热凉血解毒汤治疗血热型寻常性银屑病疗效及对外周血炎症因子的影响

发布时间：2018-04-28 06:54

本文选题：清热凉血解毒汤 + 寻常性银屑病　；参考：《中国皮肤性病学杂志》2017年08期

【摘要】：目的探讨清热凉血解毒汤治疗血热型寻常性银屑病的临床疗效及对外周血炎症因子的影响。方法选取我院2014年6月-2016年7月收治的108例血热型寻常性银屑病患者,采取随机数字表将其分成两组,每组54例。两组患者均给予常规西药治疗,观察组加用清热凉血解毒汤治疗,比较两组临床疗效、治疗前后银屑病面积与严重性指数(PASI)评分、主要证候积分、外周血炎症因子水平以及生活质量变化情况。结果观察组治疗总有效率为92.59%,与对照组(66.67%)相比有明显上升(P0.01)。两组治疗后PASI评分与治疗前比较有显著下降(P0.01)。两组患者治疗后瘙痒、红斑、心烦、口干口渴积分均较治疗前有明显下降(P0.01),观察组治疗后各项主要证候积分均明显低于对照组治疗后(P0.01)。两组患者治疗后生理状态、日常活动、心理状态、社交娱乐评分均较治疗前有明显下降(P0.01)。两组患者治疗后血清IL-6,IL-8,TNF-α水平均明显低于治疗前(P0.01)。结论清热凉血解毒汤治疗血热型寻常性银屑病可有效缓解临床症状、减轻机体炎症反应,疗效确切。
[Abstract]:Objective to investigate the clinical effect of Qingre Liangxue jiedu decoction (QXJD) on psoriasis vulgaris and its effect on inflammatory factors in peripheral blood. Methods 108 patients with blood-fever psoriasis vulgaris from June 2014 to July 2016 were randomly divided into two groups: 54 cases in each group. Patients in both groups were treated with routine western medicine, the observation group was treated with Qingreliangxue jiedu decoction. The clinical efficacy, psoriasis area and severity index (PASI) score and main syndrome score were compared between the two groups before and after treatment. Changes of peripheral blood inflammatory factor level and quality of life. Results the total effective rate of treatment in the observation group was 92.59, which was significantly higher than that in the control group (P 0.01). The PASI score of the two groups after treatment was significantly lower than that before treatment (P 0.01). After treatment, the scores of pruritus, erythema, irritation and dry mouth thirst in both groups were significantly decreased compared with those before treatment. The scores of major syndromes in the observation group were significantly lower than those in the control group after treatment. The scores of physiological state, daily activity, psychological state and social entertainment after treatment in both groups were significantly lower than those before treatment (P 0.01). The serum levels of IL-6, IL-8 and TNF- 伪 in both groups were significantly lower than those before treatment (P 0.01). Conclusion Qingre Liangxue jiedu decoction is effective in relieving clinical symptoms and inflammatory reaction of patients with blood-heat type psoriasis vulgaris.
【作者单位】：郑州市中医院;荥阳市中医院;郑州市中心医院;
【基金】：郑州市科技局科技发展项目(20140443)
【分类号】：R275.9

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