基于痰瘀伏邪理论的中医药干预不稳定型心绞痛的临床研究
本文选题:痰瘀伏邪 + 冠心病 ; 参考:《长春中医药大学》2016年硕士论文
【摘要】:目的:观察中医药联合西医标准化治疗不稳定型心绞痛的临床效果及对患者随访期间药物的安全性的评价,同时与西医标准化治疗组比较在降低患者心肌梗死、猝死等心血管事件发生率等方面的优势。方法:采用随机、多中心平行对照的试验方法。总共入选患者160例,对照组80例和治疗组80例,两组患者均给予不稳定型心绞痛的西医标准化治疗,治疗组在西医标准化治疗上合用参红通络颗粒。疗程为4周。以降低心肌梗死及猝死等心血管事件发生率为主要指标,血运重建的发生率、危险分层、生活质量、心电图疗效等为次要指标,评价其临床疗效。结果:在降低心肌梗死及猝死率方面,中医药干预组明显优于对照组;改善心绞痛症状方面,中医药干预组明显优于对照组(P0.05);在降低血运重建的发生率方面,中医药干预可明显降低血运重建率;在改善危险分层方面,中医药干预组明显优于对照组(P0.05);在改善生活质量方面,与对照组比较,PL、AS、AF、TS、DP五大方面均有显著性差异(P0.05);在改善心电图疗效方面,中医药干预组明显优于对照组(P0.05)。两组患者试验全过程各安全性指标均未见明显异常,且无严重不良反应发生。结论:以伏邪为理论基础的中医药,在不稳定型心绞痛的治疗方面疗效明确,且临床疗效胜于西医标准化治疗组,安全性高,在降低心肌梗死及猝死率、血运重建发生率,改善心绞痛症状、危险分层及心电图疗效,提高患者生活质量等各方面占有较大优势。
[Abstract]:Objective: to observe the clinical effect of traditional Chinese medicine combined with western medicine in the treatment of unstable angina pectoris and to evaluate the safety of drugs during follow-up. The advantages of cardiovascular events such as sudden death. Methods: a randomized, multicenter, parallel controlled trial was used. A total of 160 patients, 80 patients in the control group and 80 patients in the treatment group were given western standardized treatment of unstable angina pectoris. The course of treatment was 4 weeks. The clinical efficacy was evaluated by reducing the incidence of cardiovascular events such as myocardial infarction and sudden death, the incidence of revascularization, risk stratification, quality of life, and the efficacy of electrocardiogram. Results: in reducing myocardial infarction and sudden death rate, the TCM intervention group was obviously superior to the control group in improving the symptoms of angina pectoris, the TCM intervention group was obviously superior to the control group in reducing the incidence of revascularization. Chinese medicine intervention can significantly reduce the rate of revascularization; in improving the risk stratification, the Chinese medicine intervention group is significantly better than the control group (P 0.05); in improving the quality of life, Compared with the control group, there were significant differences in the five aspects of TSDP between the two groups, and the traditional Chinese medicine intervention group was better than the control group in improving the effect of electrocardiogram (ECG). There were no significant abnormalities and no serious adverse reactions in the whole process of the two groups. Conclusion: TCM based on Fuxie is more effective than Western medicine in the treatment of unstable angina pectoris. It is safe in reducing myocardial infarction and sudden death rate, and in the incidence of revascularization. Improving symptoms of angina pectoris, risk stratification and electrocardiogram effect, improving the quality of life of patients have a great advantage.
【学位授予单位】:长春中医药大学
【学位级别】:硕士
【学位授予年份】:2016
【分类号】:R259
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