宋立群教授治疗肾性血尿临床用药规律的研究

发布时间：2018-04-30 07:46

本文选题：肾性血尿 + 用药规律　；参考：《黑龙江中医药大学》2016年硕士论文

【摘要】：目的：利用统计学方法,对宋立群教授治疗肾性血尿的方药进行分析,总结其用药规律,为临床辨治肾性血尿提供理论依据与辨治方法。方法：通过整理导师宋立群教授近5年门诊肾性血尿的医案,运用SPSS19.0统计软件和STATA13.0统计软件,应用频数分析、聚类分析和普通最小二乘法等分析方法对宋立群教授的300则处方,共185味药物进行统计分析,探讨临床用药规律。结果：总结出宋立群教授用于治疗肾性血尿的频次前19味药物,分别为：侧柏炭、地榆炭、焦白术、大蓟炭、小蓟炭、生地炭、熟地炭、炒山楂、炒麦芽、炒神曲、杜仲炭、棕榈炭、茯苓、党参、黄芪、藕节炭、牛蒡子、女贞子、炙甘草。四气中使用频次前两位的为平性和温性。五味中使用频次前三位的依次是甘味药、苦味药和涩味药。归经中使用频率前三位的分别为肝、脾、胃经。药类涉及15类,前三位分别为补虚药、止血药和清热药。总结出宋立群教授用于治疗肾性血尿的药对7组,药物组合12组。经统计得到：组方用药中炭类药物应用的味数,相对于BLD(+)而言,BLD(++)和BLD(+++)的炭药味数显著上升,但是,BLD(++)和BLD(+++)的炭药味数并未显著性差异；有尿蛋白的病人炭药味数显著降低；炭类药物味数在患者性别上无显著差异。结论：1.总结得到其核心药物以四君子汤及炭类药为主,四气以平温为主,药味以甘苦涩为主,归经以肝脾胃为主；药类以补益药、止血药、清热药三类药物为主。2.归纳得出其组方用药特点：脾肾双补,肝肾同调,视为扶正；运利水湿,清热凉血,视为驱邪；善用炭药,收敛固涩,标本并重。
[Abstract]:Objective: to analyze the prescriptions of Professor Song Liqun in the treatment of renal hematuria by statistical method, summarize the rule of drug use, and provide the theoretical basis and treatment method for clinical differentiation and treatment of renal hematuria. Methods: through sorting out the medical records of outpatients with renal hematuria in outpatient clinic of Professor Song Liqun in recent 5 years, using SPSS19.0 statistical software and STATA13.0 statistical software, using frequency analysis, cluster analysis and general least square method, 300 prescriptions of Professor Song Liqun were obtained. A total of 185 kinds of drugs were statistically analyzed to explore the rule of clinical drug use. Results: the first 19 kinds of drugs used by Professor Song Liqun in the treatment of renal hematuria were summarized as follows: Platycladus orientalis charcoal, Dielm charcoal, Atractylodes macrocephala, large thistle charcoal, small artichoke charcoal, raw land charcoal, cooked land charcoal, Hawthorn, stir-fried malt, fried Shenqu, Eucommia charcoal. Palm charcoal, Poria cocos, Codonopsis, Astragalus, Lotus root charcoal, Arctium lappa, Ligustrum lucidum, grilled licorice. The first two places in the use frequency of the four gases are flatness and temperance. The top three of the five flavors are sweet flavor medicine, bitter medicine and astringent medicine. The liver, spleen and stomach were the first three most frequently used in the meridian. Drug category involves 15 categories, the first three are tonifying drugs, hemostatic drugs and heat-clearing drugs respectively. Summing up Professor Song Liqun used for the treatment of renal hematuria in 7 groups, drug combination of 12 groups. According to the statistics, the taste number of carbon drugs used in prescription medicine was significantly higher than that of BLD- () and BLD- (), but there was no significant difference between BLD- () and BLD(). The number of taste of charcoal in patients with urine protein decreased significantly, but there was no significant difference in the number of taste of carbon drugs in patients. Conclusion 1. It is concluded that its core drugs are mainly Sijunzi decoction and charcoal drugs, four qi is mainly flat temperature, the medicinal taste is mainly sweet and astringent, the meridian is mainly liver, spleen and stomach, and the drugs are mainly three kinds of drugs: tonifying drugs, hemostatic drugs, and heat-clearing drugs. 2. Summed up its prescription medicine characteristics: spleen and kidney double tonifying, liver and kidney homology, as a strengthening; transport water and moisture, clear heat and cool blood, as exorcism; make good use of charcoal medicine, astringency, astringency and astringency, the specimen is equally important.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R249;R277.5

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