复方黄杞颗粒治疗重症肌无力的临床疗效观察

发布时间：2018-05-01 13:03

本文选题：重症肌无力 + 脾肾亏虚证　；参考：《辽宁中医药大学》2016年硕士论文

【摘要】：目的:评价复方黄杞颗粒治疗脾肾亏虚型Ⅰ、Ⅱ型重症肌无力的临床疗效。材料与方法:选取确诊为脾肾两虚型Ⅰ、Ⅱ型重症肌无力的患者60例,均系2014年3月至2015年3月在辽宁中医药大学附属医院门诊就诊的患者。年龄在14-75岁之间,男性25例,女性35例。其中Ⅰ型重症肌无力患者19例,IIA型MG患者23例,IIB型MG患者18例。病程3-48个月。采用随机数字表法将所选患者按1:1分组,分为治疗组30例和对照组30例。治疗组给予复方黄杞颗粒+溴吡斯的明,对照组给予安慰剂+溴吡斯的明。疗程36周,分别于4周、8周、12周、36周观察两组患者总的临床绝对评分、中医症状总分及中医主症评分变化情况,并且观察两组患者的中西医临床疗效。对数据的统计分析应用spss17.0软件。计量资料用均数±标准差表示,首先对数据进行正态分布检验,符合正态分布者进行t检验,不符合正态分布者进行秩和检验:计数资料进行卡方检验;若P0.05,有统计学意义。结果:1.临床绝对评分总分:入组及治疗4周(4w)时两组间临床绝对评分,经t检验,组间P值0.05,无组间差异;治疗8w、12w、36W时,治疗组临床绝对评分低于对照组,组间P值0.05,组间有统计意义,差异显著。两组组内在不同时间点比较,治疗组从4周开始、8周、12周、36周分别与0周比较p0.05,有统计学差异。对照组12周、36周与0周比较p0.05,有统计学差异。2.(1)两组不同访视时间中医症状总分变化情况比较:两组间不同访视时间中医症状总分在0周时、4周时两组比较:p0.05,无显著差异;治疗8w、12w、36W时,治疗组中医症状总分低于对照组,组间P值0.05,组间有统计意义,差异显著。两组组内在不同时间点比较,治疗组从4周开始、8周、12周、36周分别与0周比较p0.05,有统计学差异。对照组12周、36周与0周比较p0.05,有统计学差异。(2)两组不同访视时中医主症评分变化情况比较:两组在0周时、4周时两组比较:p0.05,无显著差异,8周、12周、36周随访期两组比较p0.05,两组有显著差异。两组组内在不同时间点比较,治疗组从4周开始、8周、12周、36周与0周比较时p0.05,有统计学差异;对照组仅在12周、36周与0周比较时p0.05,有统计学意义。3(1)西医临床疗效:痊愈:治疗组0例(0%)、对照组为0例(0%);基本痊愈:治疗组0例(0%)、对照组为0例(0%);显效:治疗组为11例(36.67%)、对照组为3例(10%);好转:治疗组为15例(50%)、对照组为5例(16.67%);无效:治疗组为4例(13.33%),对照组为22例(73.33%)。(2)中医临床疗效:临床控制:治疗组1例(3.33%)、对照组为0例(0%);显效:治疗组为9例(30%)、对照组为2例(6.67%);有效:治疗组为16例(53.34%)、对照组为4例(13.33%);无效:治疗组为4例(13.33%),对照组为24例(80%)。结论:复方黄杞颗粒能够明显改善脾肾亏虚型Ⅰ、II型重症肌无力患者的临床症状,疗效显著。复方黄杞颗粒为防治重症肌无力提供了新方法,具有更进一步临床推广价值。
[Abstract]:Objective: To evaluate the clinical efficacy of compound Huang Qi granule in the treatment of spleen and kidney deficiency type I and type II myasthenia gravis. Materials and methods: 60 patients with two deficiency of spleen and kidney type I and type II myasthenia gravis were selected from March 2014 to March 2015 in the outpatient clinic of the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine. The age was between 14-75 years and male 2. There were 5 cases and 35 women. Among them, 19 cases of myasthenia gravis, 23 cases of type IIA MG, 18 cases of type IIB MG. The course of disease was 3-48 months. The selected patients were divided into 30 cases in the treatment group and 30 cases in the control group by random digital table method. The treatment group was given the compound yellow Qi granule + bropipidus, and the control group was given placebo + bropiopyx therapy. After 36 weeks, the total clinical absolute score of the two groups was observed in the 4 weeks, 8 weeks, 12 weeks and 36 weeks respectively. The total scores of TCM symptoms and the main symptoms of traditional Chinese medicine were observed, and the clinical curative effect of Chinese and Western medicine in two groups of patients was observed. The statistical analysis of the data was applied to SPSS17.0 software. Cloth test, the normal distribution of t test, do not conform to the normal distribution of the rank sum test: count data for chi square test; if P0.05, there is statistical significance. Results: 1. clinical absolute score total score: the group and the treatment of 4 weeks (4W) between two groups of clinical absolute score, t test, the group P value 0.05, no difference between groups; the treatment of 8W, 12W, 36W, The clinical absolute score of the treatment group was lower than the control group, the P value between the groups was 0.05, the group had statistical significance, and the difference was significant. The two groups were compared with the 4 weeks, 8 weeks, 12 weeks, 36 weeks and 0 weeks respectively, compared with the 0 weeks. The control group was 12 weeks, 36 weeks and 0 weeks compared with the 0 weeks, and there were statistically different.2. (1) two group visits different visits. The total score of TCM symptoms was compared: the total score of traditional Chinese medicine symptoms in the two groups was 0 weeks, and the two groups were compared in 4 weeks. There was no significant difference between the two groups. When the treatment group was treated with 8W, 12W, 36W, the total score of TCM symptoms was lower than the control group, and the P value between the groups was 0.05. The difference was significant between the groups. The two groups were compared with the treatment group at different time points. The treatment group was compared with the treatment group. From the 4 weeks, 8 weeks, 12 weeks and 36 weeks compared with the 0 weeks, there were statistical differences. The control group was 12 weeks, 36 weeks and 0 weeks compared with the statistical difference. (2) the two groups of different visits of traditional Chinese medicine score changes when compared: two groups at 0 weeks, 4 weeks in the group comparison: P0.05, no significant difference, week, week, weekly follow-up period compared P0.05, 36 weeks, P0.05 week, weekly follow-up period comparison group P0.05, 36 weeks, peripheral follow-up period comparison group compared P0.05, dialectical week In the two groups, the two groups were compared at different time points. The treatment group started from 4 weeks, 8 weeks, 12 weeks, 36 weeks and 0 weeks, with statistical difference. The control group was only 12 weeks, 36 weeks and 0 weeks compared with P0.05, there were statistically significant.3 (1) clinical curative effect of Western medicine: cure group 0 (0%), and the control group for 0 cases (0%); basic recovery: treatment group cases (treatment group) 0%) the control group was 0 cases (0%), the treatment group was 11 cases (36.67%), the control group was 3 (10%), the treatment group was 15 cases (50%), the control group was 5 (16.67%); the treatment group was 4 cases (13.33%), the control group was clinically effective: clinical control: the treatment group, the control group, the treatment group as the cases, The control group was 2 (6.67%), effective: the treatment group was 16 cases (53.34%) and the control group was 4 (13.33%); the treatment group was 4 cases (13.33%) and the control group was 24 (80%). Conclusion: the compound Huang Qi granule can obviously improve the clinical symptoms of the spleen and kidney deficiency type I, II type myasthenia gravis, and the effect is significant. The new method is worthy of further clinical popularization.

【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.7

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