半夏泻心汤治疗寒热错杂型反流性食管炎的疗效观察

发布时间：2018-05-02 01:17

本文选题：反流性食管炎 + 寒热错杂型　；参考：《辽宁中医药大学》2017年硕士论文

【摘要】：目的:运用辛升苦降代表方半夏泻心汤,联合奥美拉唑肠溶胶囊、瑞巴派特治疗寒热错杂型反流性食管炎,观察其治疗的临床疗效,为中西医结合治疗胃食管反流病提供临床依据。材料与方法:所选患者均出自2015年1月—2016年11月我院消化内科门诊患者,所有患者经临床诊断,均符合西医诊断反流性食管炎,中医辨证分型为寒热错杂型的诊断标准的51例患者纳入。将51例患者按照随机数字表法分为治疗组和对照组,治疗组27例和对照组24例。对照组予常规西医治疗(包括西药PPI制剂、黏膜保护剂),奥美拉唑肠溶胶囊40mg每日1次口服;瑞巴派特0.1g每日3次;治疗组在西医常规治疗的基础上加中药汤剂100ml每日3次。中药汤剂以辛升苦降之半夏泻心汤为基础方。两组患者均连续治疗4周,治疗结束后分别对治疗前、治疗后2周、治疗后4周的单项症状积分进行分析比较,对两组治疗2周、4周后的改善率及总症状积分进行比较,以及两组治疗总有效率进行对比。结果:1.治疗后单项症状积分比较,治疗组优于对照组,差异有统计学意义(P0.05),且治疗4周优于治疗2周。2.在改善患者主要临床症状方面,治疗组与对照组比较差异有统计学意义(P0.05);治疗4周各症状积分改善率优于治疗2周改善率。两组治疗2周、4周后的总症状积分均低于治疗前,比较差异有统计学意义(P0.05)。3.治疗组和对照组总有效率分别为96.30%和70.83%,治疗组与对照组比较差异有统计学意义(P0.05)。结论:与单纯西医治疗相比较,联合使用半夏泻心汤在改善寒热错杂型反流性食管炎的临床症状方面优势明显,研究表明半夏泻心汤能明显改善患者的临床症状,有较好的临床疗效。
[Abstract]:Objective: to treat reflux esophagitis with Xisheng Kujiang representative prescription Banxia Xiexin decoction combined with omeprazole enteric dissolution capsule and to observe its clinical effect. To provide clinical basis for the treatment of gastroesophageal reflux disease with integrated Chinese and western medicine. Materials and methods: all the patients were selected from the outpatient department of the Department of Digestive Medicine of our hospital from January 2015 to November 2016. All the patients were diagnosed as reflux esophagitis by Western medicine. TCM syndrome differentiation for the diagnosis of cold and heat mixed criteria of 51 patients included. 51 patients were divided into treatment group (n = 27) and control group (n = 24). The control group was treated with routine western medicine (including western medicine PPI preparation, mucosal protection agent, omeprazole enteric-coated capsule 40mg once a day; repapet 0.1g three times a day; treatment group plus traditional Chinese medicine decoction 100ml 3 times a day on the basis of western medicine routine treatment. Traditional Chinese medicine decoction is based on Banxia Xiexin decoction. The single symptom scores before treatment, 2 weeks after treatment and 4 weeks after treatment were analyzed and compared, and the improvement rate and total symptom score were compared between the two groups after 2 weeks and 4 weeks of treatment. The total effective rate was compared between the two groups. The result is 1: 1. After treatment, the single symptom score in the treatment group was better than that in the control group, the difference was statistically significant (P 0.05), and the treatment for 4 weeks was better than the treatment for 2 weeks. In improving the main clinical symptoms of the patients, the difference between the treatment group and the control group was statistically significant (P 0.05), and the improvement rate of each symptom score at 4 weeks was better than that of the control group at 2 weeks. After 2 weeks and 4 weeks of treatment, the total symptom score of the two groups was lower than that before treatment, and the difference was statistically significant (P 0.05. 3). The total effective rates of the treatment group and the control group were 96.30% and 70.83% respectively. The difference between the treatment group and the control group was statistically significant (P 0.05). Conclusion: compared with western medicine alone, Banxia Xiexin decoction combined with Banxia Xiexin decoction has obvious advantages in improving the clinical symptoms of reflux esophagitis of the type of cold and heat, and the research shows that Banxia Xiexin decoction can obviously improve the clinical symptoms of the patients. It has good clinical effect.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

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