天舒胶囊联合柴苓汤治疗慢性肾小球肾炎湿热证临床疗效观察

发布时间：2018-05-02 09:34

本文选题：慢性肾小球肾炎 + 湿热证　；参考：《南京中医药大学》2016年硕士论文

【摘要】：研究目的：观察天舒胶囊对柴苓汤治疗慢性肾小球肾炎湿热证是否存在增效作用。研究方法：选择符合西医诊断为慢性肾小球肾炎,中医辨证为湿热证的患者46例随机分为A组(治疗组)和B组(对照组)各23例。A组采用基础治疗+柴苓汤+天舒胶囊治疗,B组采用基础治疗+柴苓汤治疗。临床观察周期为8周,每4周为1疗程,连续治疗2个疗程后,通过观察疾病总疗效、证候疗效、中医症状积分变化以及实验室指标等进行评价。研究结果：疾病疗效方面,A组(治疗组)总有效率91.3%,B组(对照组)总有效率87.0%,经统计学分析P0.05,无统计学差异。证候疗效：A组总有效率86.9%,B组总有效率78.2%,经统计学分析P0.05,说明两组在证候疗效方面存在明显差异。实验室指标方面,治疗前后治疗组与对照组在降低尿红细胞计数(U-RBC)、尿蛋白定量(UTP)以及减少尿蛋白定性(PRO)方面均有效(P0.05),且治疗组比对照组在降低尿红细胞计数、尿蛋白定量方面更加有效(P0.05),而在降低尿蛋白定性方面无明显差异(P0.05)。在治疗过程中两组对血肌酐(Scr)、血尿素氮(BUN)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、血清白蛋白(ALB)、血白细胞计数(WBC)均无影响。结论：在中医辨证论治基础上,天舒胶囊对柴苓汤治疗慢性肾小球肾炎湿热证存在一定的增效作用。其增效作用表现为有利于改善患者临床症状,减少痛苦,改善生活质量；有利于消除或减少蛋白尿与血尿,有利于延缓肾小球疾病发展速度。
[Abstract]:Objective: to observe the effect of Tianshu capsule on treating chronic glomerulonephritis with damp-heat syndrome. Methods: chronic glomerulonephritis was diagnosed as chronic glomerulonephritis in accordance with western medicine. 46 patients with damp-heat syndrome were randomly divided into group A (treatment group) and group B (control group) 23 cases each. Group A was treated with basic treatment of Chailing decoction Tianshu capsule and group B was treated with basic treatment of Chailing decoction. The clinical observation period was 8 weeks, every 4 weeks as a course of treatment. After 2 consecutive courses of treatment, the total curative effect, syndromes effect, symptom integral change of TCM and laboratory index were observed and evaluated. Results: the total effective rate of group A (treatment group) was 91.3% and the total effective rate of group B (control group) was 87.0. There was no statistical difference between group A and group B (P 0.05). The total effective rate of group A was 86.9%. The total effective rate of group B was 78.2%. The statistical analysis showed that there was a significant difference in the curative effect of syndrome between the two groups. In terms of laboratory indexes, both the treatment group and the control group were effective in reducing urine red blood cell count (U-RBCU), urinary protein quantification (UTP) and urinary protein qualitative protein (PROP) before and after treatment, and the treatment group was more effective than the control group in reducing urine red blood cell count. The quantitative analysis of urinary protein was more effective than that of P0.05, but there was no significant difference in reducing the quality of urinary protein. In the course of treatment, the two groups had no effect on serum creatinine, bun, alanine aminotransferase (alt), serum albumin (Alb) and white blood cell count (WBC). Conclusion: on the basis of TCM syndrome differentiation, Tianshu capsule has a certain synergistic effect on treating chronic glomerulonephritis with damp-heat syndrome. The synergistic effect is that it can improve the clinical symptoms, reduce the pain, improve the quality of life, eliminate or reduce proteinuria and hematuria, and delay the development of glomerular diseases.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.5

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