针刺对比药物预防治疗偏头痛有效性及安全性的Meta分析

发布时间：2018-05-02 17:34

  本文选题：偏头痛 + 针刺　； 参考：《重庆医科大学学报》2017年10期

【摘要】：目的:系统评价针刺对比药物对偏头痛的预防治疗疗效及安全性,为针刺的临床应用提供循证依据。方法:检索Pubmed、The Cochrane library、EMBASE、CBM、VIP、Wan Fang Data和CNKI,检索时间为建库至2015年12月,收集针刺和药物对偏头痛的预防治疗的随机对照研究。筛选合格的文献并提取相关数据,结局数据按照随访时间分为随机后3~4月和随机后5~6月2个亚组,最后进行Meta分析。结果:根据纳入排除标准筛选后共纳入研究7项,包含1285名偏头痛患者。Meta分析结果显示,针刺组和药物组在随机分组后随访3~4月的治疗有效率(RR=1.24,95%CI=1.04~1.47,P=0.020)、偏头痛天数(SMD=-0.30,95%CI=-0.45~-0.16,P=0.000)、头痛程度(SMD=-0.32,95%CI=-0.52~-0.11,P=0.000)有统计学差异,随机分组后随访5~6月的偏头痛天数(MD=-0.66,95%CI=-1.18~-0.13,P=0.010)、头痛程度(SMD=-0.31,95%CI=-0.47~-0.15,P=0.000)也有统计学意义;而随机分组后随访5~6月的治疗有效率(RR=1.18,95%CI=0.97~1.43,P=0.110)2组间无统计学差异;因此针刺组相对药物治疗组,治疗有效率更大、偏头痛天数更少,头痛程度更轻。不良反应率由于异质性较大(I2=77%),通过描述性分析认为针刺不良反应率较药物小。结论:针刺相对药物对偏头痛的预防治疗有更好的治疗效应及安全性,但还需要更多的优质试验进一步增强循证依据。
[Abstract]:Objective: to evaluate the efficacy and safety of acupuncture contrast drugs in the prevention and treatment of migraine, and to provide evidence-based basis for the clinical application of acupuncture. Methods: the Cochrane libraryary EMBASE (CBM) VIPA Wan Fang Data and CNKI were searched. The retrieval time was established until December 2015. The randomized controlled study of acupuncture and drug therapy for migraine was collected. According to the follow-up time, the outcome data were divided into two subgroups: random 3 ~ 4 months and random 5 ~ 6 months. Finally, Meta analysis was performed. Results: according to the exclusion criteria, a total of 7 subjects were included in the study, including 1285 migraine patients. Meta-analysis showed that, 閽堝埡缁勫拰鑽�鐗╃粍鍦ㄩ殢鏈哄垎缁勫悗闅忚�，

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