小青龙汤治疗支气管哮喘临床研究

发布时间：2018-05-04 04:20

本文选题：小青龙汤 + 哮喘　；参考：《世界中西医结合杂志》2017年03期

【摘要】：目的观察支气管哮喘发作期小青龙汤干预后炎性因子的变化与临床症状的相关性。方法选取同时符合西医支气管哮喘诊断标准和中医哮病辨证标准的住院患者40例,分为对照组20例和治疗组20例,两组均给予常规对症治疗,治疗组加用中药小青龙汤。观察治疗前后临床症状及体征、外周血EOS计数、嗜酸性粒细胞趋化因子、白细胞介素8、C-反应蛋白等炎性因子水平,将炎性因子的变化与证候变化做相关性研究。结果治疗后治疗组总有效率和显效时间明显高于对照组,差异有统计学意义(P0.05);两组患者中医症状评分治疗后均比治疗前减少(P0.05),且治疗组的中医症状评分减少幅度明显大于对照组,差异有统计学意义(P0.05);两组患者治疗后外周血EOS计数、血清超敏反应蛋白(hs-CRP)、eotaxin、IL-8水平均比治疗前降低,差异有统计学意义(P0.05):且治疗组优于对照组,两组比较差异有统计学意义(P0.05);炎性因子变化与中医症候积分具有正相关性。结论小青龙汤对于治疗支气管哮喘具有良好的效果。
[Abstract]:Objective to observe the correlation between the changes of inflammatory factors and clinical symptoms after intervention of Xiao Azure Dragon decoction in bronchial asthma. Methods Forty inpatients who met the diagnostic criteria of asthma in western medicine and syndrome differentiation of TCM were divided into two groups: control group (n = 20) and treatment group (n = 20). Both groups were given routine symptomatic treatment and the treatment group was treated with Xiao Azure Dragon decoction. The clinical symptoms and signs, peripheral blood EOS count, eosinophil chemokine, interleukin-8 C-reactive protein and other inflammatory factors were observed before and after treatment, and the correlation between the changes of inflammatory factors and syndromes was studied. Results after treatment, the total effective rate and effective time in the treatment group were significantly higher than those in the control group. The difference was statistically significant (P 0.05), the scores of TCM symptoms in the two groups were lower than those before treatment, and the decrease of TCM symptom scores in the treatment group was significantly larger than that in the control group (P 0.05), and the EOS count in peripheral blood of the two groups after treatment was significantly higher than that in the control group. The levels of IL-8 in serum hs-CRPnC eotaxin were lower than those before treatment, and the difference was statistically significant (P 0.05). The treatment group was superior to the control group, and the difference between the two groups was statistically significant (P 0.05), and the change of inflammatory factors was positively correlated with the TCM symptom score. Conclusion Xiao Azure Dragon decoction has good effect on treating bronchial asthma.
【作者单位】：山东省济宁市中医院;
【分类号】：R256.12

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