脑心通胶囊治疗烟雾病慢性脑缺血的临床疗效

发布时间：2018-05-04 05:53

本文选题：烟雾病 + 阿司匹林　；参考：《中国老年学杂志》2017年12期

【摘要】：目的探讨口服脑心通胶囊和阿司匹林胶囊治疗烟雾病(MMD)慢性脑缺血患者的临床疗效。方法广州医科大学附属第二医院、广州市第一人民医院、佛山市顺德区中医院住院的MMD患者随机分为两组各30例,入院后行血常规、血液流变学、凝血功能化验、智商(IQ)、神经功能缺损评分(NDS)、日常生活能力评价(DLA)测试及颈内动脉虹以及部脑血流量的变化(通过经颅多普勒TCD)。对照组予阿司匹林胶囊,3次/d,50 mg/次口服,实验组予脑心通胶囊3次/d,1.6 g/次,都连续口服90 d。服完药物后予复测上述7项指标。结果患者经口服阿司匹林或脑心通胶囊治疗后,血液流变学指标:高切变率下全血黏度、低切变率下全血黏度、血浆黏度可得到显著改善(P0.05),而两组治疗后上述指标比较均无显著差别(P0.05)。结论脑心通胶囊与阿司匹林对于改善MMD患者血液流变学指标同样有效。
[Abstract]:Objective to investigate the clinical effect of oral Naoxintong capsule and aspirin capsule on chronic cerebral ischemia patients with moyamoya disease (MMD). Methods MMD patients in the second affiliated Hospital of Guangzhou Medical University, the first people's Hospital of Guangzhou and Shunde District Hospital of Foshan City were randomly divided into two groups: 30 patients in each group. Blood routine examination, hemorheology and coagulation function tests were performed after admission. Intelligence quotient (IQ), neurological impairment score (NDS), activity of daily living (ADL) test and the changes of internal carotid artery rainbow and cerebral blood flow (TCD-T) were evaluated by transcranial Doppler (TCD). The control group was given aspirin capsule 3 times / d 50 mg/, the experimental group was treated with Naoxintong capsule 3 times / d 1.6 g / time, all took orally continuously for 90 days. After taking the medicine, the above 7 indexes were measured again. Results after the patients were treated with aspirin or Naoxintong capsule, the hemorheological indexes were as follows: whole blood viscosity at high shear rate and whole blood viscosity at low shear rate. The plasma viscosity could be significantly improved by P0.05, but there was no significant difference between the two groups after treatment. Conclusion both Naoxintong capsule and aspirin are effective in improving hemorheology in patients with MMD.
【作者单位】：广州医科大学附属第二医院;广州市第一人民医院;佛山市顺德区中医院;
【基金】：广东省中医药管理局课题(No.20142094)
【分类号】：R277.7

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