自拟愈溃方维持缓解脾肾阳虚型溃疡性结肠炎的临床疗效研究

发布时间：2018-05-04 07:02

  本文选题：自拟愈溃方 + 溃疡性结肠炎　； 参考：《辽宁中医药大学》2016年硕士论文

【摘要】：目的:观察自拟愈溃方加减维持缓解脾肾阳虚型溃疡性结肠炎的临床疗效。方法:41例脾肾阳虚型溃疡性结肠炎患者随机分为两组,治疗组20例,给予自拟愈溃方加减口服,对照组21例,给予美沙拉秦缓释颗粒剂(艾迪莎)口服。两组均随访治疗1年。观察两组患者维持缓解率、依从性及不良反应发生情况。结果:1.试验结束时,治疗组和对照组分别有15例和10例处于维持缓解期,Kaplan-Meier生存曲线显示治疗组在溃疡性结肠炎维持缓解方面略优于对照组,但差异无统计学意义。2.两组患者均无不良反应发生。3.依从性方面,治疗组脱落2例,对照组脱落6例,差异无统计学差异。结论:1.自拟愈溃方维持缓解脾肾阳虚型溃疡性结肠炎是有效的,在抗复发方面疗效确切;2.自拟愈溃方维持缓解脾肾阳虚型溃疡性结肠炎是安全的。
[Abstract]:Objective: to observe the clinical effect of self-made Yukui prescription on relieving ulcerative colitis with deficiency of spleen and kidney yang. Methods 41 patients with ulcerative colitis with deficiency of spleen and kidney yang were randomly divided into two groups: the treatment group (n = 20) was treated with self-made Yukui decoction, and the control group (n = 21) was given mezalazine sustained release granule (Adiza). Both groups were followed up for 1 year. The maintenance remission rate, compliance and adverse reactions were observed in both groups. The result is 1: 1. At the end of the trial, 15 cases in the treatment group and 10 cases in the control group were in the maintenance stage of remission. Kaplan-Meier survival curve showed that the treatment group was slightly superior to the control group in the maintenance and remission of ulcerative colitis, but the difference was not statistically significant. There were no adverse reactions. 3. 3 in both groups. In terms of compliance, there were 2 cases in treatment group and 6 cases in control group. Conclusion 1. The self-made Yukui recipe is effective in relieving ulcerative colitis with deficiency of spleen and kidney yang and is effective in anti-recurrence. Self-made Yukui recipe is safe to relieve ulcerative colitis due to deficiency of spleen and kidney yang.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259
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本文编号：1842064