益气利湿汤治疗慢性肾炎气阴两虚湿热蕴结型蛋白尿的临床观察

发布时间：2018-05-04 14:29

本文选题：肾性蛋白尿 + 益气利湿汤　；参考：《黑龙江省中医药科学院》2017年硕士论文

【摘要】：目的:本研究主要通过临床病例观察,评价“益气利湿汤”治疗慢性肾炎气阴两虚、湿热蕴结型蛋白尿的临床疗效,为之后的临床应用提供依据。方法:所有的观察病例均来源于2016年1月-12月黑龙江省中医医院肾一科门诊慢性肾炎患者,符合纳入标准,共计60例。患者统一给予益气利湿汤治疗,疗程为8周,观察患者治疗前后尿蛋白定性试验、隐血定性试验、高倍镜下红细胞计数、24小时尿蛋白定量及中医症候积分(根据主症、次症评分)的变化并进行相关统计学分析。结果:治疗后患者的24小时尿蛋白定量结果比治疗前明显降低,治疗前后结果比较有显著性差异。治疗后中医证侯的总积分明显优于治疗前,治疗前后结果比较有显著性差异。治疗后尿沉渣红细胞计数与治疗前比较,差异无统计学意义。在治疗期间,患者并未出现明显的不良反应,治疗前后的肾功(Scr、BUN)、肝功(ALT、AST)无明显变化,差异无统计学意义。结论:1.益气利湿汤治疗慢性肾炎气阴两虚、湿热蕴结型蛋白尿,可以有效的缓解患者的临床症状,使24小时尿蛋白定量的结果显著降低。2.益气利湿汤治疗气阴两虚、湿热蕴结型慢性肾炎,对肾性血尿治疗效果不明显。3.益气利湿汤对于患者肾功(Scr、BUN)和肝功(ALT、AST)无异常影响,治疗慢性肾炎气阴两虚、湿热蕴结型蛋白尿安全可靠。
[Abstract]:Objective: to evaluate the clinical effect of "Yiqi Lishishang" in treating chronic nephritis with deficiency of Qi and Yin and accumulation of dampness and heat. Methods: all the observed cases were from chronic nephritis patients in the Department of Kidney of Heilongjiang Provincial Hospital of traditional Chinese Medicine from January to December 2016, and met the inclusion criteria, a total of 60 cases. The patients were treated with Yiqi Lishi decoction for 8 weeks. Urine protein qualitative test, occult blood qualitative test, 24 hour urine protein quantification and TCM symptom score (according to the main symptom) were observed before and after treatment. The changes of secondary symptom score were analyzed statistically. Results: the quantitative results of 24 hours urine protein in patients after treatment were significantly lower than those before and after treatment, and there were significant differences before and after treatment. After treatment, the total score of TCM syndromes was significantly better than that before treatment, and there was significant difference in the results before and after treatment. There was no significant difference in erythrocyte count between before and after treatment. During the treatment period, there was no obvious adverse reaction. There was no significant change in the renal function before and after treatment, but there was no significant difference between the two groups. Conclusion 1. The treatment of chronic nephritis with deficiency of qi and yin and accumulation of damp-heat and accumulation of proteinuria with Yiqi Lishi decoction can effectively relieve the clinical symptoms of the patients and make the results of 24 hours urine protein quantitative significantly lower. 2. Yiqi Lishi decoction for qi and yin deficiency, damp-heat accumulation knot chronic nephritis, renal hematuria treatment effect is not obvious. 3. Yiqi Lishi decoction had no abnormal effect on Scr-BUNS and alt AST in patients with chronic glomerulonephritis. It was safe and reliable in treating chronic nephritis with deficiency of Qi and Yin and accumulation of dampness and heat.
【学位授予单位】：黑龙江省中医药科学院
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R277.5

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