针刺调经促孕治疗卵巢储备功能下降的前瞻性病例序列研究

发布时间：2018-05-06 02:23

本文选题：卵巢储备功能下降 + 针刺　；参考：《中国针灸》2017年10期

【摘要】：目的:探讨针刺调经促孕治疗对卵巢储备功能下降(DOR)患者卵巢功能的影响和安全性。方法:采用前瞻性病例序列研究的方法对46例DOR患者进行观察,最终纳入分析40例。取穴:(1)百会、神庭、关元及双侧本神、肓俞、大赫、卵巢、足三里、三阴交、太溪、太冲穴;(2)双侧肾俞、次毼穴。两穴组交替使用,隔日1次,每周治疗3次,12次为一疗程,共治疗3个疗程。于治疗前后及治疗结束3个月后随访时记录患者卵泡刺激素(FSH)、卵泡刺激素/黄体生成素(FSH/LH)、雌二醇(E_2)水平及窦卵泡计数(AFC)和中医症状评分,并对患者行安全性观察。结果:与治疗前比较,治疗后及随访时FSH水平、FSH/LH比值下降、E_2、AFC水平上升(均P0.05)。治疗后及随访时中医症状评分均较治疗前显著下降(均P0.05)。治疗后临床妊娠率为15%(6/40)。无感染、脏器损伤等发生。结论:针刺调经促孕治疗对DOR患者的卵巢储备功能具有良好的改善作用,且安全性较好。
[Abstract]:Objective: to investigate the effect and safety of acupuncture regulating menstruation and promoting pregnancy on ovarian function in patients with decreased ovarian reserve function. Methods: 46 cases of DOR were observed by prospective case sequence study, and 40 cases were analyzed. Take points: 1) Baihui, Shenting, Guan Yuan and both sides of the God, Huangshu, Dahe, ovary, Zusanli, Sanyinjiao, Taixi, Tachong acupoint Gouzhu2) bilateral Shenshu, Sui points. The two groups were used alternately, once every other day, 3 times a week for 12 times as a course of treatment, a total of 3 courses of treatment. The levels of follicle stimulating hormone (FSH), follicle stimulating hormone / luteinizing hormone (FSH / LHN), estradiol (EST), antral follicle count (AFC) and TCM symptom score were recorded before and after treatment and 3 months after treatment. The safety of the patients was observed. Results: compared with before treatment, the FSH level and the ratio of FSH / LH decreased after treatment and follow up, and the level of E2AFC increased (all P 0.05). The scores of TCM symptoms after treatment and follow-up were significantly lower than those before treatment (P 0.05). The clinical pregnancy rate after treatment was 15 to 6 / 40. No infection, organ injury, etc. Conclusion: acupuncture regulating menstruation and promoting pregnancy can improve the ovarian reserve function of DOR patients, and the safety is good.
【作者单位】：中国中医科学院针灸研究所;中国中医科学院针灸医院卵巢早衰专病门诊;
【基金】：中国中医科学院基本科研业务费自主选题项目:ZZ 0908019
【分类号】：R246.3

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