温阳和胃方治疗功能性消化不良的临床研究

发布时间：2018-05-06 07:21

本文选题：功能性消化不良 + 脾胃虚寒型　；参考：《广西中医药大学》2017年硕士论文

【摘要】：目的:本研究通过观察温阳和胃方对脾胃虚寒型功能性消化不良的临床疗效、安全性以及对胃动素水平的变化,为中医药治疗功能性消化不良提供新的思路和方法。方法:本研究采用随机对照的研究方法,将符合纳入标准的功能性消化不良患者82例随机分为治疗组和对照组,每组各41例。治疗组服用温阳和胃方治疗,对照组服用枸橼酸莫沙必利片和雷贝拉唑钠肠溶片治疗,两组疗程均为4周。观察两组治疗前后中医症候、生存质量以及胃动素水平变化情况。采用SPASS17.0统计软件统计分析。结果:剔除脱落病例3例,共完成观察病例79例,其中治疗组40例,对照组39例。1.临床整体疗效比较:治疗后,治疗组总有效率为92.50%,对照组总有效率为74.36%,治疗组总有效率明显高于对照组(P0.05)。2.中医症候积分比较:治疗后,治疗组各症状较治疗前均有明显改善(P0.05);对照组胃脘疼痛、胃脘胀闷、泛吐清水、食少纳呆症状较治疗前好转(P0.05),其他症状未见好转;与对照组比较,治疗组除胃脘疼痛、泛吐清水症状外,其他症状改善均优于对照组(P0.05)。3.FDDQL比较:治疗后,治疗组在改善日常生活、忧虑、睡眠、不适、健康感觉、压力方面均明显优于对照组(P0.05);在改善饮食、疾病控制方面两组疗效相当(P0.05)。4.血浆胃动素比较:治疗后两组血浆胃动素水平均较治疗前升高,差异有统计学意义(P0.05);治疗后组间比较,治疗组血浆胃动素水平明显高于对照组,差异有统计学意义(P0.05)。5.复发率比较:治疗组复发率为16.22%,对照组复发率为41.38%,治疗组复发率明显低于对照组(P0.05)。6.安全性指标:两组患者在治疗期间均未发生不良反应。结论:1.温阳和胃方治疗脾胃虚寒型功能性消化不良的临床疗效确切,能提高患者生存质量,且复发率低,未发现不良反应,安全性好,值得临床推广应用。2.温阳和胃方治疗脾胃虚寒型功能性消化不良的作用机制可能与胃动素水平升高有关。
[Abstract]:Objective: to observe the clinical efficacy, safety and changes of motilin level of Wenyang Hewei recipe in the treatment of functional dyspepsia with deficiency of spleen and stomach, and to provide a new way of thinking and method for the treatment of functional dyspepsia with traditional Chinese medicine. Methods: 82 patients with functional dyspepsia were randomly divided into treatment group and control group with 41 cases in each group. The treatment group was treated with Wenyang and Wei decoction, the control group was treated with mosapride citrate tablets and rabeprazole enteric coated tablets. The course of treatment in both groups was 4 weeks. The changes of TCM symptoms, quality of life and motilin level before and after treatment were observed. SPASS17.0 statistical software was used for statistical analysis. Results: three cases were excluded and 79 cases were observed, including 40 cases in the treatment group and 39 cases in the control group. Comparison of the overall clinical efficacy: after treatment, the total effective rate of the treatment group was 92.50 and the total effective rate of the control group was 74.36. The total effective rate of the treatment group was significantly higher than that of the control group (P 0.05). Comparison of TCM symptom score: after treatment, the symptoms in the treatment group were significantly improved compared with those before treatment; in the control group, the symptoms of epigastric pain, distention and boredom were significantly improved; in the control group, the symptoms of stomach ache, distension, vomiting and dyspnea were improved compared with those before treatment, but the other symptoms were not improved; compared with the control group, The improvement of other symptoms in the treatment group was better than that in the control group (P 0.05). 3. Comparison of FDDQL: after treatment, the treatment group improved daily life, anxiety, sleep, discomfort and health feeling. Stress was significantly better than that of control group (P 0.05), and the effect of two groups on improving diet and disease control was similar to that of control group (P 0.05). Comparison of plasma motilin: after treatment, the plasma motilin level of the two groups was higher than that before treatment, the difference was statistically significant (P 0.05), and after treatment, the plasma motilin level of the treatment group was significantly higher than that of the control group, and the difference was statistically significant. The recurrence rate of the treatment group was 16.22 and that of the control group was 41.38. The recurrence rate of the treatment group was significantly lower than that of the control group. Safety index: there was no adverse reaction during treatment in both groups. Conclusion 1. The clinical effect of Wenyang Hewei recipe in treating functional dyspepsia with deficiency of spleen and stomach is definite, it can improve the quality of life of the patients, and the recurrence rate is low, no adverse reactions are found, and the safety is good. It is worth popularizing and applying in clinic. The mechanism of Wenyang Hewei recipe in treating functional dyspepsia with deficiency of spleen and stomach may be related to the increase of motilin level.
【学位授予单位】：广西中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

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