痰热清注射液对慢性阻塞性肺疾病急性加重期hs-CRP、IL-6、IL-10的影响

发布时间：2018-05-07 08:01

本文选题：痰热清注射液 + 慢性阻塞性肺疾病急性加重期　；参考：《广西中医药大学学报》2017年01期

【摘要】：[目的]观察痰热清注射液对慢性阻塞性肺疾病(COPD)急性加重期痰热郁肺证患者血清超敏C反应蛋白(hsCRP)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)的影响。[方法]采取随机对照的方法将70例COPD急性加重期痰热郁肺证患者随机分为对照组和治疗组,每组各35例,对照组给予抗感染、止咳化痰、解痉平喘等常规治疗,治疗组在对照组常规治疗基础上加用痰热清注射液20 ml/d治疗,疗程为7 d。分别于治疗前后进行症候评分及检测血清中hs-CRP、IL-6、IL-10水平。[结果]治疗组总有效率为94.3%,对照组总有效率为77.1%,两组疗效对比,差异具有统计学意义(P0.05);治疗组治疗后症状、体征积分明显下降,且优于对照组(P0.05);两组治疗后血清hs-CPR、IL-6水平降低(P0.05),血清IL-10水平升高(P0.05),且治疗组优于对照组(P0.05)。[结论]痰热清注射液可降低COPD急性加重期痰热郁肺证患者血清中hs-CRP、IL-6水平,提高IL-10水平,治疗COPD急性加重期痰热郁肺证患者有明确的疗效。
[Abstract]:[objective] to observe the effect of Tanreqing injection on serum hypersensitive C-reactive protein (hsCRPN), interleukin-6 (IL-6) and interleukin-10 (IL-10) in patients with acute exacerbation of chronic obstructive pulmonary disease (COPDD). [methods] 70 patients with acute exacerbation of COPD were randomly divided into two groups: control group (n = 35) and treatment group (n = 35). The control group was given routine treatment such as anti-infection, relieving cough and eliminating phlegm, and relieving spasm and asthma. The treatment group was treated with Tanreqing injection for 20 ml/d on the basis of routine treatment in the control group for 7 days. The symptom score and the level of hs-CRP IL-6 and IL-10 in serum were measured before and after treatment. [results] the total effective rate of the treatment group was 94.3 and the total effective rate of the control group was 77.1. The difference between the two groups was statistically significant (P 0.05). It was better than the control group (P 0.05), and the serum hs-CPR IL-6 level was lower than that of the control group (P 0.05), the serum IL-10 level was increased (P 0.05), and the treatment group was superior to the control group (P 0.05). [conclusion] Tanreqing injection can decrease the serum hs-CRP IL-6 level and increase the IL-10 level in the patients with phlegm-heat stagnation lung syndrome in acute exacerbation of COPD. It has a definite curative effect on the patients with phlegm-heat stagnation lung syndrome in acute exacerbation of COPD.
【作者单位】：广西中医药大学附属瑞康医院;
【分类号】：R259

【相似文献】