糖肾灌肠方对糖尿病肾病合并高尿酸患者的临床疗效观察

发布时间：2018-05-07 09:00

  本文选题：糖尿病肾病Ⅲ期 + 高尿酸血症　； 参考：《新疆医科大学》2016年硕士论文

【摘要】：目的:观察以通腑泄浊为法的糖肾灌肠方治疗2型糖尿病肾病(Type 2 diabetic nephropathy,T2DN)合并无症状高尿酸血症(Hyperuricemia,HUA)的临床疗效。方法:把入组的60名2型糖尿病肾病Ⅲ期合并无症状高尿酸血症患者随机分成2组,治疗组采用西医疗法(采用低蛋白低嘌呤饮食,每日饮水量保持在2000ml以上,口服降糖药物或(和)胰岛素皮下注射控制血糖,并配合血管紧张素受体拮抗剂(Angiotensin Receptor Blocker,ARB)缬沙坦80mg,日一次,口服;合并高血压者,配合钙离子拮抗剂),在此基础上加用糖肾灌肠方(中药灌肠药液组成:生大黄30g、煅牡蛎50g、泽泻30g、丹参15g、槐花30g、附子15g、黄芩30g。灌肠方法:将药浓煎取汁,温度为37℃-38℃,一次性输液管插入肛门20-30cm,每次灌入250ml,保留30min以上,每晚1次),对照组采用单纯西医疗法(采用低蛋白低嘌呤饮食,每日饮水量保持在2000ml以上。口服降糖药物或(和)胰岛素皮下注射控制血糖,并配合ARB药物缬沙坦80mg,日一次,口服;合并高血压者,配合钙离子拮抗剂),治疗疗程为20天,在治疗前后分别对尿微量蛋白、尿酸、空腹血糖、甘油三酯、总胆固醇等指标进行检测。结果:(1)本试验纳入分析共60例,治疗组30例,对照组30例;(2)指标比较:治疗组在改善尿微量白蛋白、尿酸、空腹血糖方面明显优于对照组(P0.05),治疗组在改善甘油三酯、总胆固醇与对照组疗效相当(P0.05)。结论:糖肾灌肠方在对糖尿病肾病Ⅲ期合并无症状高尿酸血症患者的治疗中,对减少尿微量白蛋白,降低尿酸、空腹血糖方面的治疗优于单纯西医治疗组。在治疗糖尿病肾病Ⅲ期及高尿酸血症中安全有效,值得临床推广。
[Abstract]:Objective: to observe the clinical effect of Tangshen enema decoction (TXD) in treating type 2 diabetic nephropathy (T2DN) with asymptomatic hyperuricemia. Methods: sixty patients with type 2 diabetic nephropathy and asymptomatic hyperuricemia were randomly divided into two groups. The treatment group was treated with western medicine (low protein and low purine diet, the daily water intake was above 2000ml). Taking hypoglycemic drugs or / and insulin subcutaneously to control blood glucose, combined with Angiotensin Receptor Blocker ARB80 mg, once a day, in patients with hypertension, In combination with calcium antagonist, Tang Shen enema prescription was added (composition of traditional Chinese medicine enema liquid: raw rhubarb 30g, calcined oyster 50g, alisma sinensis 30g, salvia miltiorrhiza 15g, Sophorae japonica 30g, aconite 15g, baicalin 30g. Enema method: extract juice by concentrated decoction, temperature was 37 鈩，

本文编号：1856296