温中养胃合剂治疗功能性消化不良（寒热错杂证）的临床观察

发布时间：2018-05-07 13:24

本文选题：温中养胃合剂 + 临床观察　；参考：《成都中医药大学》2016年硕士论文

【摘要】：研究目的：本研究通过观察温中养胃合剂(绵阳市中医医院院内制剂)对功能性消化不良(functional dyspepsia, FD)寒热错杂证患者的总体疗效及临床症状改善情况,初步探讨温中养胃合剂治疗FD寒热错杂证患者的疗效、复发率、安全性等,为临床上运用及今后进一步研究提供依据。研究方法：本研究选取绵阳市中医医院脾胃科门诊中符合纳入标准的60例患者,随机分为治疗组和对照组。治疗组30例,予温中养胃合剂口服;对照组30例,予多潘立酮(吗丁啉)+奥美拉唑肠溶胶囊口服,每周复诊1次,连续治疗4周。在治疗期间两组均不允许服用其它药物,劳逸适度,并忌饮咖啡、浓茶,禁食辛辣刺激、冷硬、油腻之物等。主要观察项目为临床有效率、中医症状积分、复发率等指标,用SPSS21.0软件对数据统计分析,做出相关临床疗效判定。研究结果：1.临床有效率比较：治疗组总有效率为89.66%,对照组总有效率为79.31%。对两组有效率进行秩和检验,组间差异无统计学意义(PO.05)。2.中医症状疗效比较： (1)组内比较：治疗组治疗前后单项中医症状积分比较差异均有统计学意义(P0.05)；对照组治疗前后单项中医症状积分在大便稀溏、遇冷加重、肢体发凉上差异无统计学意义(P＞0.05),其余症状积分上差异具有统计学意义(P0.05)。(2)组间比较：治疗组与对照组治疗后中医症状积分在胃脘部胀满、胃脘疼痛、口干口苦、大便稀溏、遇冷加重、肢体发凉症状上差异均具有统计学意义(P0.05),尤其在改善胃脘部胀满不适、大便稀溏、遇冷加重、肢体发凉这几项症状积分上具有显著性差异(P0.01)。3.复发率比较：治疗结束后随访2个月,对照组复发14例,治疗组复发6例,经统计分析,两组比较差异具有统计学意义(P0.05)结论：温中养胃合剂能有效治疗FD(寒热错杂证)患者,总体有效率与多潘立酮片+奥美拉唑肠溶胶囊组相当,但在改善FD患者某些临床症状、减少复发率等方面治疗组优于对照组。温中养胃合剂治疗FD(寒热错杂证)疗效显著,且复发率小,服药简单,值得进一步研究和临床推广。
[Abstract]:Objective: to observe the general curative effect and the improvement of clinical symptoms of wenzhong Yangwei mixture (Mianyang traditional Chinese Medicine Hospital) on patients with functional dyspepsia (FDD). To explore the curative effect, recurrence rate and safety of Wenzhong Yangwei mixture in the treatment of FD patients with mixed cold and heat, and to provide the basis for clinical application and further study in the future. Methods: 60 patients in the outpatient department of spleen and stomach of Mianyang traditional Chinese Medicine Hospital were randomly divided into treatment group and control group. 30 cases in the treatment group were treated with Wenzhong Yangwei mixture and 30 cases in the control group were treated with domperidone (morpholine) omeprazole enteric capsule once a week for 4 weeks. During the treatment period, both groups were not allowed to take other drugs, moderate labor, and avoid coffee, strong tea, fasting spicy stimulation, cold and hard, greasy, and so on. The main observation items were clinical effective rate, TCM symptom score, recurrence rate and so on. The data were statistically analyzed by SPSS21.0 software, and the related clinical curative effect was judged. The result of the study was: 1. The total effective rate was 89.66 in the treatment group and 79.31 in the control group. The effective rate of the two groups was tested by rank sum test, and there was no significant difference between the two groups. Comparison of Therapeutic effects of TCM symptoms: comparison of TCM symptom scores before and after treatment in treatment group: there were significant differences in the scores of single TCM symptoms before and after treatment in the treatment group; in the control group, the scores of symptoms of single TCM before and after treatment were in loose stools, which did not increase as expected. There was no significant difference on the upper part of extremity hair and cooling (P > 0.05), but there was significant difference in the other symptom scores between the two groups: after treatment, the scores of TCM symptoms in the treatment group and the control group were full of stomach distention, epigastric pain, dry mouth and bitter mouth, and loose stool. There were significant differences in the symptoms of extremity cooling, especially in the improvement of stomach distention, loose stool, not like expected aggravation. There was significant difference in the scores of the symptoms of extremity hair and cooling (P 0.01g. 3), especially in the improvement of stomach distension and discomfort, loose stools, not like the expected aggravation, and there was significant difference in the scores of the symptoms of extremity cooling. Comparison of recurrence rate: 14 cases in control group and 6 cases in treatment group were followed up for 2 months after treatment. Statistical analysis showed that the difference between the two groups was statistically significant (P 0.05). Conclusion: Wenzhong Yangwei mixture can effectively treat FDD patients. The overall effective rate was similar to that of omeprazole enteric-coated capsule group, but the treatment group was superior to the control group in improving some clinical symptoms and reducing recurrence rate of FD patients. The effect of Wenzhong Yangwei mixture in the treatment of FDs is remarkable, and the recurrence rate is small, and the medication is simple, so it is worth further study and clinical popularization.
【学位授予单位】：成都中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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