降糖通络颗粒治疗糖尿病周围神经病变（气虚血瘀型）的临床观察

发布时间：2018-05-09 05:56

本文选题：降糖通络颗粒 + 糖尿病周围神经病变(气虚血瘀型)　；参考：《河南中医药大学》2016年硕士论文

【摘要】：目的:观察降糖通络颗粒对糖尿病周围神经病变(气虚血瘀型)的临床疗效。方法:选择与入组要求相符的DPN(气虚血瘀型)患者60例,选用随机、对照的方法分为治疗组:30例,给予基础治疗+甲钴胺片+降糖通络颗粒;对照组:30例,给予基础治疗+甲钴胺片,观察时间为8周。以中医证候积分、神经传导速度等观察其治疗效果的测评指标,评价其临床治疗效果。结果:1.中医证候:两组患者在用药后的中医症候积分都较用药前减低,但治疗组症状积分减低较对照组明显;用药后治疗组有效率为90%,与对照组用药后(60%)有显著差异(P0.05)。2.FPG、2h PG及Hb Alc:两组用药后FPG、2h PG及Hb Alc均减少,但治疗后治疗组与对照组FPG、2h PG、Hb Alc有显著差异(P0.05)。3.肌电图:治疗组和对照组用药后MCV、SCV指标都比用药前好转,但对照组用药前后这2个指标组内相比无差异(P0.05);治疗组用药前后2个指标组内相比有差异(P0.05),且与对照组用药后相比MCV指标有差异(P0.05),SCV指标有显著统计学意义(P0.01)。4.感觉阈值测定、踝肱指数:治疗组治疗后VPT、ABI指标和治疗前相比差异有意义(P0.05);对照组用药后VPT、ABI和用药前相比无差异(P0.05);用药后治疗组与对照组VPT、ABI指标相比有显著差异(P0.01)。结论:降糖通络颗粒能够改善糖尿病周围神经病变(气虚血瘀型)患者的临床症状、体征,使中医证候积分下降,有效提高患者NCV指标(运动传导速度、感觉传导速度),调节VPT、ABI指标。
[Abstract]:Objective: to observe the clinical effect of Jiangtang Tongluo granule on diabetic peripheral neuropathy (qi deficiency and blood stasis type). Methods: sixty patients with DPN (deficiency of qi and blood stasis) were selected and randomly divided into treatment group (n = 30) and control group (n = 30). Mecobalamin tablets were treated with basic therapy for 8 weeks. The therapeutic effect was evaluated by TCM syndrome integral, nerve conduction velocity and so on. The result is 1: 1. TCM syndromes: the scores of TCM symptoms in the two groups were lower than those before medication, but the symptom scores in the treatment group were significantly lower than those in the control group. The effective rate of the treatment group was 90, which was significantly different from that of the control group (P0.05N. 2. FPGG 2 h PG and HB Alc): the 2 h PG and HB Alc decreased in both groups, but there was a significant difference between the treatment group and the control group in 2 h PGH Alc (P0 05. 3). Electromyography (EMG): the SCV index of MCV in treatment group and control group were better than before. However, there was no difference between the two indexes before and after treatment in the control group (P 0.05), and there was significant difference between the two indexes in the treatment group (P 0.05) and the MCV index in the control group (P 0.05). The malleolus brachial index after treatment in the treatment group was significantly different from that before treatment (P 0.05), but there was no difference between the control group and the control group (P 0.05), and there was significant difference between the treatment group and the control group (P 0.01). Conclusion: Jiangtang Tongluo granule can improve the clinical symptoms and signs of patients with diabetic peripheral neuropathy (qi deficiency and blood stasis type), decrease the integral of TCM syndromes, and effectively increase the NCV index (motor conduction velocity). Sensory conduction velocities were measured to regulate the ABI index of VPTV.
【学位授予单位】：河南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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