背俞穴埋线疗法治疗支气管哮喘的临床观察及对血清IL-4的影响

发布时间：2018-05-10 06:01

本文选题：背俞穴 + 穴位埋线　；参考：《广西中医药大学》2016年硕士论文

【摘要】：目的:通过观察背俞穴埋线疗法对支气管哮喘患者的临床症状、发作次数及血清白介素-4的影响,研究该疗法对支气管哮喘的临床疗效及相关作用机制。方法:依据统一的纳入标准,将62例支气管哮喘患者随机分成治疗组与对照组各31例。对照组给予口服氨茶碱缓释片治疗,治疗组在对照组的基础上采用背俞穴埋线疗法,3个月为一疗程,分别治疗一个疗程。两组患者均于治疗前及治疗结束后观察中医证候积分及血清IL-4水平,治疗结束后随访3个月观察哮喘发作次数,判定其临床疗效。结果:本研究实际完成病例60例,其中治疗组30例,对照组30例。1、两组治疗完成后,治疗组总有效率为93.33%,对照组总有效率为80.00%。两组疗效相比较,差异有非常显著统计学意义(P0.01),治疗组疗效明显优于对照组。2、观察指标的变化:两组患者治疗后中医证候积分及血清IL-4水平均较治疗前非常显著降低(P0.01),说明两种治疗方案均能非常显著改善哮喘患者症状体征及降低血清IL-4的水平。两组治疗后相比较,治疗组患者的中医证候积分及血清IL-4水平均非常显著低于对照组(P0.01),表明治疗组在改善哮喘患者症状体征及降低血清IL-4水平均明显优于对照组。治疗结束后随访3个月,观察两组患者哮喘的发作次数,治疗组哮喘发作次数非常显著低于对照组哮喘发作次数(P0.01),说明治疗组疗效更持久,更能控制哮喘的发作。结论:背俞穴埋线疗法可明显改善哮喘患者症状体征、降低血清IL-4水平及减少哮喘的发作次数。其作用机制可能与降低患者血清中IL-4的水平来减少气道炎性反应,调节机体免疫状态有关。背俞穴埋线疗法操作简便、安全、疗效持久、无明显毒副作用,有利于哮喘的长期稳定控制,值得在临床上推广应用。
[Abstract]:Objective: To observe the clinical symptoms, the number of episodes and the influence of serum interleukins -4 on the patients with bronchial asthma, and to study the clinical effect and mechanism of this therapy on bronchial asthma. Methods: according to the unified inclusion criteria, 62 patients with bronchial asthma were randomly divided into 31 cases of the treatment group and the control group. The control group was given oral Aminophylline Sustained-release Tablets treatment. The treatment group was treated with back Shu acupoint catgut embedding therapy on the basis of the control group. 3 months as a course of treatment, one course of treatment was treated respectively. The scores of TCM syndrome and serum IL-4 were observed before and after the end of treatment. The number of asthma attacks was observed after 3 months of follow-up after the treatment. Results: 60 cases were completed in this study, including 30 cases in the treatment group and 30 cases of.1 in the control group. The total effective rate of the treatment group was 93.33% after the two groups were completed. The total effective rate of the control group was compared with the 80.00%. two group, the difference was statistically significant (P0.01). The curative effect of the treatment group was obviously better than the control group.2, the observation index was obviously better than that of the control group. Changes in two groups of patients after treatment of TCM syndrome scores and serum IL-4 level were significantly lower than before the treatment (P0.01), indicating that the two treatments can significantly improve the symptoms and signs of asthma patients and reduce the level of serum IL-4. Compared with the two groups after treatment, the TCM syndromes score and the serum IL-4 level are very significant. The treatment group was significantly lower than the control group (P0.01), which showed that the treatment group was better than the control group in improving the symptoms and signs of asthma and reducing the level of serum IL-4. After 3 months of follow-up, the number of asthma attacks in the two groups was observed. The number of asthma attacks in the treatment group was significantly lower than that of the group of asthma attacks (P0.01), indicating the curative effect of the treatment group. Conclusion: the catgut embedding therapy in the back Shu point can obviously improve the symptoms and signs of asthmatic patients, reduce the level of serum IL-4 and reduce the frequency of asthma attacks. The mechanism of its action may be related to reducing the level of IL-4 in the serum of the patients to reduce the inflammatory reaction of the airway and regulating the immune state of the body. The catgut embedding therapy on the back Shu point It is easy to operate, safe, durable, and has no obvious side effects. It is beneficial to the long-term stable control of asthma, and is worthy of clinical application.

【学位授予单位】：广西中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R246.1

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