中药提取物葵花盘粉治疗高尿酸血症的临床观察及安全性评价

发布时间：2018-05-10 23:08

本文选题：高尿酸血症 + 葵花盘粉　；参考：《吉林大学》2017年硕士论文

【摘要】：[目的]从中西医两个不同的角度详述高尿酸血症的病因病机、治疗进展、以及于其他疾病的关系。观察葵花盘粉治疗高尿酸血症的临床疗效,评价葵花盘粉临床安全指标,为高尿酸血症患者给予一种新的用药选择。[资料与方法]收集2015年10月-2016年10月期间符合标准的高尿酸血症患者70例,随机分配成两组。观察组35例,男31例,女4例,平均年龄40.03±11.70岁。观察组高尿酸血症伴高血压病4例,伴冠心病者5例,伴糖尿病者7例,伴贫血者1例,伴脑梗塞3例,伴肾脏疾病2例。对照组35例,男28例,女7例,平均年龄43.09±12.32岁。对照组高尿酸血症患者伴高血压病8例,伴冠心病者8例,伴糖尿病者8例,伴哮喘者1例,伴脑梗塞3例,伴肾脏疾病者1例。观察组给予中草药葵花盘粉颗粒制剂,每日1次,每次服用10g,饭后服用,1个月1疗程。对照组给予别嘌醇片0.1 g,每日2次,1个月为1个疗程。1月后观察治疗前后两组SUA、BUN、Cr、ALT、AST指标的变化情况。[结果]通过对观察组及对照组的统计分析,两组的性别、年龄、临床检验值无显著性差异,具有可比性(P0.05)。观察组临床显著有效8例,临床有效26例,临床无效1例,有效率为97.14%;对照组临床显著有效0例,临床有效30例,临床无效5例,有效率为85.71%。两组疗效经秩和检验,z值为-3.201,P(0.001),P0.05,具有统计学意义。数据分析显示观察组疗效明显,对照组降SUA水平处于下势。治疗前两组BUN均值经独立样本T检验,P(0.537),P0.05,无统计学意义,两组可以进行比较。观察组BUN经过前后治疗,选择配对T检验统计分析,P(0.001),P0.05,说明观察组BUN指标下降显著,有统计学意义。观察组和对照组治疗后BUN经独立样本T检验,P(0.001),P0.05,具有统计学意义。两组治疗后,观察组BUN的均值下降,而对照组BUN均值上升,说明观察组的药物能够整体降低BUN的水平。治疗前两组Cr均值经独立样本T检验,P(0.484),P0.05,无统计学意义,两组可进行比较。观察组Cr经过前后治疗,选择配对样本T检验分析,P(0.000),P0.05,说明观察组Cr指标显著降低,有统计学意义。两组治疗后Cr经独立样本T检验,P(0.002),P0.05,具有统计学意义。两组治疗后,观察组Cr的均值下降,而对照组Cr均值上升,说明观察组的药物能够整体降低Cr的水平。治疗前两组AST均值经独立样本T检验,P(0.787),P0.05,无统计学意义,两组可进行比较。观察组治疗前后AST经配对样本T检验,P(0.758),P0.05,无统计学意义。观察组和对照组治疗后AST经独立样本T检验,P(0.320),P0.05,无统计学意义,说明观察组和对照对AST的影响无显著差异。观察组治疗前后ALT经配对样本T检验,P(0.057),P0.05,无统计学意义。两组治疗后ALT经独立样本T检验,P(0.713),P0.05,无统计学意义,说明两组药物对ALT的影响无统计学意义。[结论]葵花盘粉通过现代生物酶提取技术,减少内生尿酸生成,加速尿酸的排泄,起到降低血尿酸的综合作用。葵花盘粉能够减少BUN、Cr的数值,既能降低血尿酸,同时又能保护肾功。葵花盘粉对ALT、AST的指标无影响,前后均值下降虽无统计学意义,说明对肝功能影响不大。
[Abstract]:[Objective] to detail the etiology and pathogenesis of hyperuricemia, treatment progress and the relationship between other diseases from two different angles of Chinese and Western medicine. The clinical efficacy of sunflower disc powder in the treatment of hyperuricemia was observed, the clinical safety index of sunflower disc powder was evaluated and a new choice of medication for patients with hyperuricemia was given. [data and methods] collected 2015 In the period of October -2016 October, 70 cases of hyperuricaemia were randomly assigned to two groups. There were 35 cases in the observation group, 31 men and 4 women, with the average age of 40.03 + 11.70 years. There were 4 cases of hyperuricemia with hypertension, 5 patients with coronary heart disease, 7 cases of diabetes with diabetes, 1 cases with anemia, 3 cases of cerebral infarction, 2 cases of renal disease. There were 28 cases of male and 7 women, with an average age of 43.09 + 12.32 years. The control group with hyperuricemia was accompanied by hypertension, 8 cases, 8 cases of coronary heart disease, 8 cases of diabetes, 1 cases of asthma, 3 cases of cerebral infarction and 1 cases of kidney disease. The observation group was given Chinese herbal medicine with sunflower disc powder preparation, once a day, taking 10g every time, after meals, 1 courses for 1 months. The control group was given Allopurinol Tablets 0.1 g, 2 times a day, 1 months for 1 courses of.1 months after observation of two groups of SUA, BUN, Cr, ALT, AST index changes. [results] through the statistical analysis of the observation group and the control group, the two groups of sex, age, clinical test value had no significant difference (P0.05). The observation group was significantly effective in clinical 8. 26 clinical cases were effective, 1 cases were ineffective, the effective rate was 97.14%, the control group was clinically effective 0 cases, clinical effective 30 cases and clinical invalid 5 cases, the effective rate was 85.71%. two group by rank sum test, the Z value was -3.201, P (0.001), P0.05, and the data analysis showed that the observation group had obvious curative effect, and the SUA level in the control group was lower in the lower level. Before treatment, the average BUN of the two groups was tested by independent sample T, P (0.537) and P0.05, without statistical significance. The two groups could be compared. The observation group was treated with BUN before and after, and selected the statistical analysis of paired T test, P (0.001), P0.05, indicating that the BUN index of the observation group decreased significantly and had the significance of overall planning. The BUN of the observation group and the control group were tested by independent samples T test, P (0) .001), P0.05, with statistical significance. After two groups of treatment, the mean value of BUN in the observation group decreased, while the mean value of BUN in the control group increased, indicating that the drugs in the observation group were able to reduce the level of BUN as a whole. The mean Cr value of the group before the treatment was tested by independent sample T test, P (0.484), P0.05, no statistical significance, and the two groups could be compared. The observation group was treated with Cr before and after the treatment, selection. Paired samples T test analysis, P (0), P0.05, indicating that the observation group Cr indicators significantly decreased, statistically significant. Two groups after treatment Cr independent sample T test, P (0.002), P0.05, with statistical significance. After two groups of treatment, the mean of Cr in the observation group decreased, while the control group Cr mean increased, indicating that the drug in the observation group can reduce Cr level. Before and after treatment, the average AST of the two groups was tested by independent sample T, P (0.787) and P0.05 without statistical significance. The two groups could be compared. The observation group was tested by paired samples T test, P (0.758), P0.05, without statistical significance before and after treatment. The observation group and the control group were tested by independent sample T, P (0.320), P0.05, with no statistical significance, indicating the observation group and the control. There was no significant difference in the effect on AST. ALT was tested by paired samples before and after treatment in the observation group, P (0.057), and P0.05 had no statistical significance. The two groups were treated by independent sample T test, P (0.713), P0.05, without statistical significance, indicating that the effect of two groups of drugs on ALT was not statistically significant. [Conclusion] sunflower disc powder was reduced by modern bioenzyme extraction technology. Endophytic uric acid is produced to accelerate uric acid excretion, and it plays a comprehensive role in reducing uric acid. Sunflower disc powder can reduce the value of BUN and Cr, which can not only reduce the blood uric acid, but also protect the renal function. The sunflower disc powder has no effect on the index of ALT and AST, although the mean decrease in the mean time is not statistically significant, indicating that the effect of the liver function is not significant.

【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

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