活血化瘀组方治疗原发性血小板增多症的临床研究

发布时间：2018-05-11 11:06

本文选题：原发性血小板增多症 + 活血化瘀组方　；参考：《南京中医药大学》2016年硕士论文

【摘要】：目的：通过对比临床上在原发性血小板增多症(essential thrombocythemia, ET)治疗中使用活血化瘀组方联合西医治疗的患者与单纯西医治疗的患者的治疗效果,评估中西医结合治疗在ET中的治疗情况,观察中西医结合治疗ET的临床疗效,最后对活血化瘀组方联合西医治疗是否更具优势提供依据。方法：本次研究病例均来自2015年2月至2016年1月期间于江苏省中医院血液科病房及血液科专病门诊就诊的ET病例,共纳入30例病例,根据患者意愿及临床实际,分别采用活血化瘀组方联合西医治疗以及单纯西医治疗,并根据治疗方法不同分为中西医结合组以及西医组。以4周为1疗程,观察2个疗程。比较患者治疗前后血小板计数、中医证候积分的改善情况,对比两种治疗方法的临床总有效率,从而对活血化瘀组方联合西医治疗ET的疗效进行初步评估。结果：中西医结合组19例：采用活血化瘀组方联合西医治疗ET患者2疗程后血小板计数由治疗前(674.63±238.69)降至(563.32±169.72)×109/L；中医证候积分由(8.64±3.02)降至(2.24±0.89)；根据中医证候疗效判定标准,临床缓解2/19例、显效12/19例、有效3/19例,中医证候疗效总有效率89.47%;根据西医疗效标准,有效1/19例、部分有效3/19例,西医疗效总有效率21.05%。西医组11例：单纯使用西医治疗ET患者2疗程后血小板计数由治疗前(698.45±305.02)降至(609.18±334.26)×109/L；中医证候积分由(15.73±5.08)降至(14.00±4.20)；根据中医证候疗效判定标准,临床缓解0/11例、显效0/11例、有效2/11例,中医证候疗效总有效率18.18%;根据西医疗效标准,有效1/11例、部分有效2/11例,西医疗效总有效率27.27%。结论：在西医治疗基础上,采用活血化瘀组方治疗ET疗效肯定,患者的血小板计数较之单纯西医治疗下降更明显,并且临床症状得到有效缓解,同时具有安全性高、经济、副作用少、患者依从性较高的优势,具有临床应用前景。
[Abstract]:Objective: to compare the therapeutic effect of combined western medicine with Huoxue Huayu recipe in the treatment of primary thrombocytosis (ETT), and to evaluate the treatment of integrated traditional Chinese and western medicine in et. To observe the clinical effect of combined traditional Chinese and western medicine on et, and finally to provide the basis for the combination of traditional Chinese medicine and western medicine for promoting blood circulation and removing blood stasis. Methods: from February 2015 to January 2016, all the patients in this study were collected from the Department of Hematology of Jiangsu Provincial traditional Chinese Medicine Hospital and the outpatient clinic of Hematology. A total of 30 cases were included, according to the wishes of the patients and the clinical practice. Huoxue Huayu group prescription combined with western medicine treatment and simple western medicine treatment, and according to the treatment methods are divided into integrated traditional Chinese and western medicine group and Western medicine group. Four weeks were used as a course of treatment and two courses of treatment were observed. To compare the improvement of platelet count and TCM syndrome integral before and after treatment, and to compare the total effective rate of two treatment methods, so as to evaluate the curative effect of Huoxue Huayu decoction combined with western medicine in treating et. Results: in the combined TCM and western medicine group, the platelet count decreased from 674.63 卤238.69 to 563.32 卤169.72 脳 10 9 / L after 2 courses of treatment, and the score of TCM syndromes decreased from 8.64 卤3.02 to 2.24 卤0.89. The total effective rate of TCM syndromes is 89.47. According to the western medicine curative effect, there are 1 / 19 effective cases, 3 / 19 partial effective cases, and 21.0555 effective rate of western medicine. Western medicine group (n = 11): platelet count decreased from 698.45 卤305.02 before treatment to 609.18 卤334.26 脳 10 9 / L; TCM syndrome score decreased from 15.73 卤5.08) to 14.00 卤4.20; according to the criteria of TCM syndromes, there were 0 / 11 cases of clinical remission, 011 cases of remarkable effect, and 2 / 11 cases of effective. The total effective rate of TCM syndromes is 18.18; according to the western medicine curative effect standard, the effective rate is 1 / 11 cases, the partial effective rate is 2 / 11 cases, the total effective rate of western medicine curative effect is 27.2727%. Conclusion: on the basis of western medicine treatment, the curative effect of promoting blood circulation and removing blood stasis in treating et is certain, the platelet count of patients is more obvious than that of western medicine alone, and the clinical symptoms are effectively alleviated, at the same time, it is safe and economical. With less side effects and higher compliance, it has clinical application prospect.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

【相似文献】